The human lanosterol synthase gene maps to chromosome 21q22.3

Human Genetics

Volumn 97, Issue 5, 1996, Pages 620-624

  Young, Michele ^a   Chen, Haiming ^a   Lalioti, Maria D ^a   Antonarakis, Stylianos E ^a,b  

^a UNIVERSITY OF GENEVA   (Switzerland)

^b GENEVA UNIVERSITY HOSPITALS   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; LANOSTEROL; LANOSTEROL SYNTHASE; SQUALENE DERIVATIVE;

ARTICLE; CHROMOSOME 21Q; CONTROLLED STUDY; COSMID; DNA LIBRARY; EXON; FETUS; GENE MAPPING; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HYBRID CELL; MARKER GENE; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; RAT; SEQUENCE HOMOLOGY; TRISOMY 21; YEAST ARTIFICIAL CHROMOSOME;

MAMMALIA;

EID: 0030007314     PISSN: 03406717     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02281872     Document Type: Article

References (22)

1. Altschul SF, Gish W, Miller W, Myers EW, Lipman DJ (1990) Basic local alignment search tool. J Mol Biol 215:403-410
2. Antonarakis SE (1993) Human chromosome 21: genome mapping and exploration circa 1993. Trends Genet 9:142-148
3. Buckler AJ, Chang DD, Graw SL, Brook JD, Haber DA, Sharp PA, Housman DE (1991) Exon amplification: a strategy to isolate mammalian senes based on RNA splicing. Proc Natl Acad Sci USA 88:4005-4009
4. Chen HM, Chrast R, Rossier C, Morris MA, Lalioti MD, Antonarakis SE (1995) Cloning of portions of approximately 40% of the genes on human chromosome 21 by exon trapping. Am J Hun Genet 57: A142
5. Cheng JF, Boyartchuk V, Zhu YW (1994) Isolation and mapping of human chromosome 21 cDNA: progress in constructing a chromosome 21 expression map. Genomics 23:75-84
6. Chumakov IM, Rigault P, Guillou S, Ougen P, Billaut A, Guasconi G, Gervy P, LeGall I, Soularue P, Grinas L, Bougueleret L, Bellarine-Chantelot C, Lacroix B, Barillot E, Gesnouin P, Pook S, Vayssiex G, Frelat G, Schmitz A, Sambucy JL, Bosch A, Estivill X, Weissenbach J, Vignal A, Riethman H, Cox D, Patterson D, Gardiner K, Hattori M, Sakaki Y, Ichikawa H, Ohki M, Le Paslier D, Heilig R, Antonarakis SE, Cohen D (1992) A continuum of overlapping clones spanning the entire chromosome 21. Nature 359:380-387
7. Church DM, Stotler CJ, Rutter JL, Murrell JR, Trofatter JA. Buckler AJ (1994) Isolation of genes from complex sources mammalian genomic DNA using exon amplification. Nature Genet 6:98-105
8. Corey EJ, Dean PDG, Ortiz de Montellando PR, Bloch K (1966) A soluble 2,3-oxidosqualene sterol cyclase. J Biol Chem 242:3014-3019
9. Corey EJ, Matsuda SPT, Bartel B (1994) Molecular cloning, characterization, and overexpression of ERG7. the Saccharomyces cerevisiae gene encoding lanosterol synthase. Proc Natl Acad Sci USA 91:2211-2215
10. Delabar JM, Theophile D, Rahmani Z, Chettouh Z, Blouin JL, Prieur M, Noel B, Sinet PM (1993) Molecular mapping of twenty-four features of Down syndrome on chromosome 21. Eur J Hum Genet 1:114-124
11. Gibco BRL (1994) Exon trapping system. Instruction manual 18449-017
12. Korenberg JR, Chen XN, Schipper R, Sun Z, Gonsky R, Gerwehr S, Carpenter N, Daumer D, Dignan P, Disteche C, Graham JM, Hugdins L, McGillivray B, Miyazaki K, Ogasawara N, Park JP, Pagon R, Pueschel S, Sack G, Say B, Schuffenhauer S, Soukup S, Yamanaka T (1994) Down syndrome phenotypes: the consequences of chromosomal inbalance. Proc Natl Acad Sci USA 91:4997-5001
13. Kusano M, Shibuya M, Sankawa U, Ebizuka Y (1995) Molecular cloning of cDNA encoding rat 2,3-oxidosqualene: lanosterol cyclase. Biol Pharm Bull 18:195-197
14. Lucente D, Chen HM, Shea D, Samec SN, Rutter M, Chrast R, Rossier C, Buckler A, Antonarakis SE, McCormick MK (1995) Localization of 102 exons to a 2.5 Mb region involved in Down syndrome. Hum Mol Genet 4:1305-1311
15. McCormick MK, Schinzel A, Petersen MB, Stetten G, Driscoll DJ, Cantu, ES, Tranebjaerg L, Mikkelsen M, Watkins PC, Antonarakis SE (1989) Molecular genetics approach to the characterization of the "Down syndrome region" of chromosome 21. Genomics 5:325-331
16. Mclnnis MG, Chakravarti A, Blaschak J, Petersen MB, Sharma V, Avramopoulos D, Blouin JL, Konig U, Brahe C, Cox Matise T. Warren AC, Talbot CC Jr. Van Broeckhoven C, Lilt M, Antonarakis SE (1993) A linkage map of human chromosome 21: 43 markers at average interval of 2.5 cM. Genomics 16:562-571
17. Nizetic D, Gellen L, Hamvas RMJ, Mott R, Grigoriev A, Vatcheva R, Zehetner G, Yaspo ML, Dutriaux A, Lopes C, Delabar JM, Van Broeckhoven C, Potier MC, Lehrach H (1994) An integrated YAC-overlap and "cosmid-pocket" map of the human chromosome 21. Hum Mol Genet 3:759-770
18. Patterson D, Rahmani Z, Donaldson D, Gardiner K. Jones C (1993) Physical mapping of chromosome 21. Prog Clin Biol Res 384: 33-50
19. Peterson A, Patil N, Robbins C, Wang L, Cox DR, Myers RM (1994) A transcript map of the Down syndrome critical region on chromosome 21. Hum Mol Genet 3:1735-1742
20. Roessner CA, Min C, Hardin SH, Harris-Haller LW, McCollum JC, Scott AI (1993) Sequence of the Candida albicans erg7 gene. Gene 127:149-150
21. Soeda E, Hou DX, Osoegawa Y, Atsuchi T, Yamagata T, Shimokawa H, Kishida H, Soeda E, Okano S, Chumakov I, Cohen D, Raff M, Gardiner K, Graw S, Patterson D, De Jong P, Ashworth L. Slezak T, Carrano A (1995) Cosmid assembly and anchoring to human chromosome 21. Genomics 25:73-84
22. Xu H , Wei H, Tassone F, Graw S, Gardiner K, Weissman S (1995) A search for genes from the dark band regions of human chromosome 21. Genomics 27:1-8