Searching for new TNF-α analogs having potential application in cancer therapy

Pflugers Archiv European Journal of Physiology

Volumn 431, Issue 6 SUPPL. 2, 1996, Pages

  Menart, V ^a   Kus, B ^a   Novakovic S ^b   Sersa G ^b   Gaberc Porekar, V ^c   Harb, V ^a   Milicic S ^a   Stalc A ^a  

^a Lek dd   (Slovenia)

^b INSTITUTE OF ONCOLOGY   (Slovenia)

^c NATIONAL INSTITUTE OF CHEMISTRY   (Slovenia)

Author keywords

Analogs; Cancer; Cytotoxicity; Disulfide bond; Histidine residues; Pharmacokinetics; TNF ; Tumor

Indexed keywords

LK 801; LK 802; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; CONFERENCE PAPER; CONTROLLED STUDY; CYTOTOXICITY; DISULFIDE BOND; DRUG BLOOD LEVEL; DRUG ELIMINATION; DRUG PURIFICATION; FIBROSARCOMA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR GROWTH;

EID: 0030007190     PISSN: 00316768     EISSN: None     Source Type: Journal    
DOI: 10.1007/bf02346354     Document Type: Conference Paper

References (8)

1. Van Ostade X, Tavernier J, Fiers W (1994), Structure-activity studies of human tumour necrosis factors. Protein Eng 7: 5-22
2. Lienard D, Delmotte JJ, Renard N, Ewalenko P, Lejeune FJ (1992), High-dose recombinant tumour necrosis factor-alpha in combination with interferon gamma and melphalan in isolation perfusion of the limbs for melanoma and sarcoma. J Clin Oncol 10:52-60
3. Menart V, Gaberc-Porekar V, Harb V (1994), Metal-affinity Separations of Model Proteins Having Differently Spaced Clusters of Histidine Residues, in: Separations for Biotechnology 3, ed. D.L. Pyle (The Royal Society of Chemistry, Thomas Graham House, Cambridge): 308-313
4. Wingfield P, Pain RH, Craig S (1987), Tumour necrosis factor is a compact trimer, FEBS Lett 211: 179-184
5. Corti A, Fassina G, Marcucci F, Barbanti E, Cassani G (1992), Oligomeric tumour necrosis factor α slowly converts into inactive forms at bioactive levels, Biochem J 284: 905-910
6. Aderka D, Engelmann H, Maor Y, Brakebusch C, Wallach D, (1992), Stabilization of the Bioactivity of Tumor Necrosis Factor by Its Soluble Receptors, J Exp Med 175: 323-329
7. Serša G, Novaković S, Štalc A (1992), Antitumor effect of recombinant human tumor necrosis factor-α analog combined with desmuramyl dipeptides LK-409 or LK-410 on sarcoma in mice. Mol Biother 4: 188-192
8. Kus B, Serša G , Novaković S, Urbančič J, Štalc A (1993), Modification of TNF-α pharmacokinetics in SA-1 tumor-bearing mice. Int J Cancer 55: 110-114