Analysis of the DRPLA triplet repeat in brain tissue and leukocytes from schizophrenics

Psychiatric Genetics

Volumn 6, Issue 1, 1996, Pages 1-5

  Jones Brando, L ^a   Yolken, R ^a   Herman, M M ^b   Kleinman, J E ^b   Ross, C A ^a,c   Torrey, E F ^b  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^c JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

DRPLA; Schizophrenia; Triplet repeats

Indexed keywords

TRINUCLEOTIDE;

ARTICLE; BRAIN TISSUE; CLINICAL ARTICLE; CONTROLLED STUDY; DENTATORUBROPALLIDOLUYSIAN ATROPHY; GENE SEQUENCE; HUMAN; HUMAN TISSUE; LEUKOCYTE; MONOZYGOTIC TWINS; PRIORITY JOURNAL; SCHIZOPHRENIA;

EID: 0030007087     PISSN: 09558829     EISSN: None     Source Type: Journal    
DOI: 10.1097/00041444-199621000-00001     Document Type: Article

References (16)

1. Burke JR, Wingfield MS, Lewis KE, Roses AD, Lee JE, Hulette C, Pericak-Vance MA and Vance JM (1994) The Haw river syndrome: dentatorubropallidoluysian atrophy (DRPLA) in an African-American family. Nature Genetics, 7, 521-524.
2. Folstein SE (1989) Huntington's Disease. A Disorder of Families. Johns Hopkins University Press, Baltimore.
3. Hinds HL, Ashley CT, Sutcliffe JS, Nelson DL, Warren ST, Housman DE and Schalling M (1993) Tissue specific expression of FMR-1 provides evidence for a functional role in fragile X syndrome. Nature Genetics, 3, 36-43.
4. Kleinman JE, Hyde TM and Herman MM (1995) Methodological issues in the neuropathology of mental illness. In: Psychopharmacology: The Fourth Generation of Progress (Eds FE Bloom and DJ Kupfer), pp. 859-864. Raven Press, New York.
5. Koide R, Ikeuchi T, Onodera O, Tanaka H, Igarashi S, Endo K, Takahashi H, Kondo R, Ishikawa A, Hayashi T, Saito M, Tomoda A, Miike T, Naito H , Ikuta F and Tsuji S (1994) Unstable expansion of CAG repeat in hereditary dentatorubral-pallidoluysian atrophy (DRPLA). Nature Genetics, 6, 9-13.
6. Kruyer H, Mila M, Glover G, Carbonell P, Ballesta F and Estivill X (1994) Fragile X syndrome and the (CGG)n mutation: two families with discordant MZ twins. American Journal of Human Genetics, 54, 437-442.
7. La Spada AR, Paulson HL and Fischbeck KH (1994) Trinucleotide repeat expansion in neurological disease. Annals of Neurology, 36, 814-822.
8. Lesch KP, Stöber G, Balling U, Franzek E, Li S-H, Ross CA, Newman M, Beckmann H and Riederer P (1994) Triplet repeats in clinical subtypes of schizophrenia: variation at the DRPLA (B37 CAG repeat) locus is not associated with periodic catatonia. Journal of Neural Transmission, 98, 153-157.
9. Li S-H, McInnis MG, Margolis RL, Antonarakis SE and Ross CA (1993) Novel triplet repeat containing genes in human brain: cloning, expression, and length polymorphisms. Genomics, 16, 572-579.
10. Margolis RL, Li S-H, Young WS, Wagster MV, Stine OC, Kidwai AS, Ashworth RG and Ross CA (1996) DRPLA gene (atrophin-1) sequence and mRNA expression in human brain. Molecular Brain Research, in press.
11. Nagafuchi S, Yanagisawa H, Sata K, Shirayama T, Ohsaki E, Bundo M, Takeda T, Tadokoro K, Kondo I, Murayama N, Tanaka Y, Kikushima H, Umino K, Kurosawa H, Furukawa T, Nihei K, Inoue T, Sano A, Komure O, Takahashi M, Yoshizawa T, Kanazawa I and Yamada M (1994) Dentatorubral and pallidoluysian atrophy expansion of an unstable CAG trinucleotide on chromosome 12p. Nature Genetics, 6, 14-18.
12. Ross CA, McInnis MG, Margolis RL and Li S-H (1993) Genes with triplet repeats: candidate mediators of neuropsychiatric disorders. Trends in Neuroscience, 16, 254-260.
13. Rubinsztein DC, Leggo J, Goodburn S, Barton DE, Ferguson-Smith MA, Ross CA, Li S-H, Lofthouse R, Crow TJ and DeLisi LE (1994) B37 repeats are normal in most schizophrenic patients. British Journal of Psychiatry, 164, 851-852 (letter).
14. Shastry BS (1994) Heritable trinucleotide repeats and neurological disorders. Experientia, 50, 1099-1105.
15. Torrey EF, Bowler AE, Taylor EH and Gottesman II (1994) Schizophrenia and Manic-Depressive Disorder. BasicBooks, New York.
16. Warren ST and Nelson DL (1993) Trinucleotide repeat expansions in neurological disease. Current Opinion in Neurobiology, 3, 752-759.