Drosophila differentiation genes instrumental in tumor suppression

International Journal of Developmental Biology

Volumn 40, Issue 1, 1996, Pages 149-156

  Gateff, Elisabeth ^a   Kurzik Dumke, Ursula ^a   Wismar, Jasmine ^a   Löffler, Thomas ^a   Habtemichael, Negusse ^a   Konrad, Lutz ^b   Dreschers, Stephan ^a   Kaiser, Sibylle ^a   Protin, Ursula ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

^b PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

Differentiation; Drosophila; Tumor suppressor genes

Indexed keywords

ANIMAL TISSUE; ARTICLE; BLOOD CELL; CELL TRANSFORMATION; CONTROLLED STUDY; DEVELOPMENTAL GENETICS; DIFFERENTIATION; DROSOPHILA; GENE MUTATION; IMAGINAL DISC; NEUROBLAST; NONHUMAN; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE;

ANIMALS; DROSOPHILA; FEMALE; GENES, INSECT; GENES, TUMOR SUPPRESSOR; HEAT-SHOCK PROTEINS; HSP40 HEAT-SHOCK PROTEINS; MALE; MOLECULAR CHAPERONES; MULTIGENE FAMILY; ZINC FINGERS;

EID: 0030007052     PISSN: 02146282     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (61)

1. ATENCIO, D.P. and YAFFE, M.P. (1992) MASS, a yeast homolog of DnaJ involved in mitochondrial protein import. Mol Cell Biol. 122: 283-291.
2. BARDWELL, J.C A , TILLY, K , CRAIG, E., KING, J , ZYLICZ, M , GEORGOPOULOS, C. (1986). The nucleotide sequence of the Eschenchia coli K12 dnaj gene: a gene that encodes a heat shock protein. J Biol Chem. 261: 1782-1785.
3. BERLETH, T., BURRI, M , THOMA, G., BOPP, D., RICHSTEIN, S., FRIGERIO, G., NOLL, M. and NÜSSLEIN-VOLHARD, C (1988). The role of localization of bicoid RNA in organizing the anterior pattern of the Drosophila embryo. EMBO J 7 1749-1756.
4. BISHOP, J.G.III and CORCES, V.G (1988) Expression of an activated ras gene causes developmental abnormalities in transgenic Drosophila melanogaster Genes Dev. 2 567-577
5. BLUMBERG, H. and SILVER, P.A. (1991). A homologue of the bacterial heat shock gene DnaJ that alters protein sorting in yeast. Nature 349: 627-630.
6. BORNEMANN, D , MILLER, E. and SIMAR, J (1996) The Drosophila Polycomb group gene sex comb on midleg (scm) encodes a zinc-finger protein with similarity to polyhomeotic protein Development. (In press).
7. BRYANT, P.J (1993). Toward the cellular functions of tumor suppressors Trends Cell Biol. 3: 31-35.
8. BRYANT, P J , WATSON, K.L., JUSTICE, R.W. and WOODS, D.F. (1993). Tumor suppressor genes encoding proteins required for cell interactions and signal transduction in Drosophila. Development (Suppl): 239-249.
9. BURTIS, K C. and BAKER, B.S (1989). Drosophila doublesex gene controls somatic sexual differentiation by producing alternatively spliced mRNA5 encoding related sex specific polypeptides. Cell 56: 997-1010
10. CAPLAN, A J. and DOUGLAS, M G. (1991). Characterization of YDJ1: A yeast homologue of the bacterial dnaJ protein. J Cell Biol. 114: 609-621.
11. CAUDY, M , VASSIN, H., BRAND, M., TUMA, R., JAN, L.Y. and JAN, Y.N. (1988). daughterless, a Drosophila gene essential for both neurogenesis and sex determination, has sequence similarities to myc and the achaete-scute complex Cell 55: 1061-1067.
12. CHEETHAM, M.E., BRION, J-P and ANDERTON, B.H (1992). Human homologues of the bacterial heat-shock protein DnaJ are preferentially expressed in neurons Biochem. J. 284: 469-476.
13. FRIGERIO, G , BURRI, M., BOPP, D., BAUMGARTNER, S. and NOLL, M. (1986). Structure of the segmentation gene paired and the Drosophila PRO gene set as part of a gene network Cell 47: 735-746.
14. FU, X-D. and MANIATIS, T (1992). Isolation of a complementary DNA that encodes the mammalian splicing factor SC35. Science 256: 535-538
15. GATEFF, E. (1978a) Malignant and benign neoplasms of Drosophila melanogaster. In The Genetics and Biology of Drosophila, Vol. 2B (Eds. M Ashburner and T.R F Wright). Academic Press, New York, pp. 182-261.
16. GATEFF, E (1978b). Malignant neoplasms of genetic origin in the fruit fly Drosophila melanogaster Science 200: 1448-1459.
17. GATEFF, E. (1982a). Cancer, genes and development, the Drosophila case In Advances of Cancer Research, Vol. 37 (Eds. S. Weinhouse and G Klein). Academic Press, London, pp 33-69.
18. GATEFF, E. (1982b). Gonial cell neoplasm of genetic origin affecting both sexes of Drosophila melanogaster. In Embryonic Development, Part B: Cellular Aspects (Eds M.M Burger and R. Weber) A R. Liss Inc., New York, pp. 621-632.
19. GATEFF, E. (1994) Tumor suppressor and overgrowth suppressor genes of Drosophila melanogaster. Developmental aspects. Int. J Dev Biol. 38: 565-590.
20. GATEFF, E. and MECHLER, B.C. (1989). Tumor suppressor genes of Drosophila melanogaster. In Critical Reviews on Oncogenesis. Vol. 1 (Ed E. Pimentel). CRC Press, Miami, pp. 221-245.
21. GATEFF, E and MIYAMOTO, T (1990), The tumor suppressor gene lethal (3)malignant brain tumor l(3)mbt of Drosophila melanogaster: Multiple functions during development. Contrib. Oncol. 39: 135-141.
22. GATEFF, E , LÖFFLER, T. and WISMAR, J. (1993). A temperature-sensitive brain tumor suppressor mutation of Drosophila melanogaster: Developmental studies and molecular localization of the gene. Mech. Dev. 41: 15-31.
23. GOMEZ, S.L., GOTER, J W and SHAPIRO, L. (1990). Expression of the Caulobacter heat shock gene dnaK is developmentally controlled during growth at normal temperatures J. Bacteriol. 172: 3051-3059.
24. GUNDACKER, D., PHANNAVONG, B., VEF, O., GATEFF, E., KURZIK-DUMKE, U (1993). Genetic and molecular characterization of breakpoints of five deficiencies in the genomic region 59F-60A Drosophila Inf. Serv. 72: 129-131
25. HENKEMEYER, M J , GERTLER, F.B., GOODMAN, W. and HOFFMANN, F.M. (1987) The Drosophila Abelson proto-oncogene homolog: identification of mutant alleles that have pleiotropic effects late in development. Cell 51: 821-828.
26. HOLLSTEIN, M., SIDRANSKY, D , VOGELSTEIN, B and HARRIS, C.C. (1991). p53 mutations in human cancer. Science 253: 49-53.
27. HOOVER, K K , CHIEN, A.J. and GORGES, V G (1993). Effect of transposable elements on the expression of forked gene of Drosophila melanogaster. Genetics 135: 507-526.
28. HUNTER, T. (1991). Cooperation between oncogenes. Cell 64: 249-270.
29. KAISER, S. (1994). Klomerung, Expressionsanalyse und Sequenzierung des benign(2)gonial cell neoplasm Gens von Drosophila melanogaster Dissertation Thesis, Johannes Gutenberg-University, Mainz, Germany.
30. KLUG, A. and RHODES, D. (1987). Zinc fingers, a protein motif for nucleic acid recognition. Trends Biochem. Sci. 12 464-468.
31. KONRAD, L , BECKER, G., SCHMIDT, A., KLÖCKNER, T., KAUFER-STILLGER, G., DRESCHERS, S , EDSTROM, J.F and GATEFF, E (1994). Cloning, structure, cellular localization and possible function of the tumor suppressor gene lethal(3)malignant blood neoplasm-1 of Drosophila melanogaster. Dev. Biol. 763: 98-111.
32. KRISHNAN, H B and PUEPPKE, S.G. (1991). Nolc, a Rhizobium fredi gene involved in cultivar-specific nodulation of soybean, shares homology with a heat-shock gene Mol. Microbiol. 5: 737-746.
33. URZIK-DUMKE, U., PHANNAVONG, B., GUNDACKER, D., GATEFF, E. (1992). Genetic, cytogenetic and developmental analysis of the Drosophila melanogaster tumor suppressor gene lethal(2)tumorous imaginal discs [l(2)tid]. Differentiation 51: 91-104.
34. KURZIK-DUMKE, U., GUNDACKER, D., RENTROP, M. and GATEFF, E. (1995). Tumor suppression in Drosophila is causally related to the function of the lethal(2)tumorous imaginal discs gene, a dnaJ homolog. Dev. Genet. 16: 64-76.
35. LAMOND, A I. (1993) The spliceosome BioEssays 15: 595-603
36. LATHIGRA, R B., YOUNG, D B., SWEETSER, D and YOUNG, R.A. (1988) A gene from Mycobacterium tuberculosis which is homologous to the DnaJ heat shock protein of E. coli Nucleic Acids Res. 16: 1636.
37. LUKE, M.M , SUTTON, A. and ARNDT, K T. (1991). Characterization of SIS1, a Saccharomyces cerevisiae homologue of bacterial dnaJ proteins J Cell Biol 114: 623-638
38. MOUNT, S.M , PETTERSSON, I., HINTERBERGER, M , KARMAS, A. and STEITZ, J A (1983). The U1 small nuclear RNA-protein complex selectively binds a 5′ splice site in vitro. Cell 33: 509-518.
39. NURSE, P. (1990) Universal control mechanisms regulating onset of M-phase Mature 344: 503-508.
40. OHKI, M , TAMURA, R., NISHIMURA, S. and UCHIDA, H. (1986). Nucleotide sequence of the Escherichia coli dnaJ gene and purification of the gene product. J Biol. Chem 261: 1778-1781
41. ORR-WEAVER, T L.(1994) Developmental modification of the Drosophila cell cycle Trends Genet. 10: 321-327.
42. PONTING, C.P (1995) SAM: A novel motif in yeast sterile and Drosophila polyhomeotic proteins. Protein Sci. 4: 1928-1930.
43. PROTIN, U. (1994). Genetische und molekulargenetishe Charakterisierung des benign(2)gonial cell neoplasm Tumorsuppressorgens von Drosophila melanogaster Dissertation Thesis. Johannes Gutenberg-University, Mainz, Germany
44. RAABE, T. and MANLEY, J L. (1991). A human homologue of the Escherichia coli DnaJ heat-shock protein. Nucleic Acids Res. 19: 6645.
45. RIZKI, T M. (1978) The circulatory system and associated cells and tissues In The Genetics and Biology of Drosophila, Vol. 2b (Eds. M Ashburner and T.M.F. Wright). Academic Press, London, pp. 397-448.
46. ROTHBLATT, J.A , DESHAIES, R J., SANDERS, S.L , DAUM, G. and SCHEKMAN, R. (1989). Multiple genes are required for proper insertion of secretory proteins. J Cell Biol. 109: 2641-2652.
47. SADLER, I., CHIANG, A., KURIHARA, T., ROTHBLATT, J., WAY, J and SILVER, P. (1989). A yeast gene important for protein assembly into the endoplasmic reticulum and the nucleus has homology to DnaJ, an Escherichia coli heat shock protein. J. Cell Biol. 109: 2665-2675.
48. SAINT, R. and WIGLEY, P.L. (1992). Developmental regulation of the cell cycle Curr. Opin. Genet. Dev. 2: 614-620
49. SCHRÖDER, H , LANGER, T., HARTL, F-U. and BUKAU, B (1993) DNAK, DNAJ and GrpE form a cellular chaperone machinery capable of repairing heat-induced protein damage. EMBO J. 12: 4137-4144
50. SCHUPBACH, T. (1985) Normal female germ cell differentiation requires the female chromosome to autosome ratio and expression of Sex-lethal in Drosophila melanogaster. Genetics 109: 529-548.
51. SHRESTHA, R. and GATEFF, E (1982). Ultrastructure and cytochemistry of the cell-types in the larval hematopoietic organs and hemolymph of Drosophila melanogaster. Dev. Growth Differ. 24: 65-82
52. SHRESTA, R. and GATEFF, E. (1986). Ultrastructure and cytochemistry of the tumorous blood cells in the mutant lethat(3)malignant blood neoplasm of Drosophila melanogaster. J. Invertebr Pathol 48: 1-12
53. SIMON, M.A., DRESS, B , KORNBERG, T and BISHOP, J M. (1985). The nucleotide sequence and the tissue-specific expression of Drosophila c-src Cell 42: 831-840.
54. STEINERT, P.M , MACK, J W., KORGE, B P., GAN, S-Q , HAYNES, S.R. and STEVEN, A C (1991). Glycine loops in proteins: Their occurrence in certain intermediate filament chains, loricrins and single-stranded RNA binding proteins Int J. Biol. Macromol 13: 130-140
55. STRAND, D., UNGER, S , CORVI, R., HARTENSTEIN, K., SCHENKEL, H., KALMES, A., MERDES, G., NEUMANN, B , KRIEG-SCHNEIDER, F., COY, J.F., POUSTKA, A., SCHWAB. M. and MECHLER, B M. (1995) A human homologue of the Drosophila tumor suppressor gene I(2)gl maps to 17p11.2-12 and codes for a cytoskeletal protein that associates with nonmuscle myosin II heavy chain. Oncogene 11, 291-301.
56. STUART, R A., CYR, D.M., CRAIG, E A and NEUPERT,W (1994). Mitochondrial molecular chaperones: their role in protein translocation. Trends Biochem. Sci. 19: 87-92.
57. TEPASS, U., FESSLER, L.I., AZIZ, A. and HARTENSTEIN, V. (1994). Embryonic origin of hemocytes and their relationship to cell death in Drosophila Development 120: 1829-1837.
58. WATSON, K.L. and BRYANT, P.J (1993) Drosophila tumor suppressor genes and their human homologs Trends Cell Biol. 3: 39-42.
59. WETZSTEIN, M DEDIO, J. and SCHUMANN, W (1990). Complete nucleotide sequence of the Bacillus subtilis dnaK gene. Nucleic Acids Res 18: 21/2.
60. WISMAR, J., LÖFFLER. T., HABTEMICHAEL, N., VEF, O., GEISSEN, M., ZIRWES, R , ALTEMEYER, W , SASS, H. and GATEFF, E. (1995) The Drosophila tumor suppressor gene lethal(3)malignant brain tumor encodes a proline-rich protein with a novel zinc finger. Mech. Dev. 53: 141-152.
61. ZAMORE, P.D. and GREEN, M.R. (1992). Biochemical localization of U2 snRNP auxiliary factor an essential pre-mRNA splicing factor with a novel intranuclear distribution. EMBO J 10: 207-214