Opioids and rate of positively reinforced behavior: Differential antagonism by naltrexone

Behavioural Pharmacology

Volumn 7, Issue 3, 1996, Pages 205-215

  Pitts, R C ^a   West, J P ^a   Morgan, D ^a   Dykstra, L A ^a,b   Picker, M J ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

Naltrexone; Opioid antagonists; pA2 analysis; Positive reinforcement; Rat; Schedule controlled responding

Indexed keywords

3,4 DICHLORO N METHYL N [2 (1 PYRROLIDINYL)CYCLOHEXYL]BENZENEACETAMIDE; BREMAZOCINE; BUTORPHANOL; FENTANYL; KAPPA OPIATE RECEPTOR; MORPHINE; MU OPIATE RECEPTOR; NALBUPHINE; NALORPHINE; NALTREXONE; OPIATE AGONIST; OPIATE ANTAGONIST; PENTAZOCINE; PENTOBARBITAL;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG ANTAGONISM; FOOD; INSTRUMENTAL CONDITIONING; MALE; NONHUMAN; RAT; REINFORCEMENT; SUBCUTANEOUS DRUG ADMINISTRATION;

EID: 0030006381     PISSN: 09558810     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. Arunlakshana O and Schild HO (1959) Some quantitative uses of drug antagonists. British Journal of Pharmacology, 14, 48-58.
2. Bergman J and Warren PH (1989) Effects of kappa opioids on schedule-controlled behavior in squirrel monkeys. Journal of Pharmacology and Experimental Therapeutics, 248, 1102-1108.
3. 2 analysis. Journal of Pharmacology and Experimental Therapeutics, 243, 591-597.
4. Downs DA and Woods JH (1976) Morphine, pentazocine and naloxone effects on responding under a multiple schedule of reinforcement in rhesus monkeys and pigeons. Journal of Pharmacology and Experimental Therapeutics, 196, 298-306.
5. Dykstra LA and Massie CA (1988) Antagonism of the analgesic effects of mu and kappa opioid agonists in the squirrel monkey. Journal of Pharmacology and Experimental Therapeutics, 246, 813-821.
6. Dykstra LA, Gmerek DE and Woods JH (1987) Kappa opioid agonists in rhesus monkeys: II. Analysis of the antagonist actions of quadazocine and β-funaltrexamine. Journal of Pharmacology and Experimental Therapeutics, 242, 421-427.
7. 2 analysis. In: Transduction Mechanisms of Drug Stimuli (Eds FC Colpaert and RL Balster), pp. 107-121. Springer Verlag, Berlin.
8. France CP, Medzhiradsky F and Woods JH (1994) Comparison of kappa opioids in rhesus monkeys: behavioral effects and receptor binding affinities. Journal of Pharmacology and Experimental Therapeutics, 268, 47-58.
9. Harris RA (1980) Interactions between narcotic agonists, partial agonists and antagonists evaluated by schedule-controlled behavior. Journal of Pharmacology and Experimental Therapeutics, 213, 497-503.
10. Horan P, de Costa BR, Rice KC, Haaseth RC, Hruby VJ and Porreca F (1993) Differential antagonism of U69,593- and bremazocine-induced antinociception by quadazocine: further evidence of opioid kappa receptor multiplicity in the mouse. Journal of Pharmacology and Experimental Therapeutics, 266, 926-933.
11. Leander JD (1983a) A kappa opioid effect: increased urination in the rat. Journal of Pharmacology and Experimental Therapeutics, 224, 89-94.
12. Leander JD (1983b) Further study of kappa opioids on increased urination. Journal of Pharmacology and Experimental Therapeutics, 227, 35-41.
13. Martin WR (1967) Opioid antagonists. Pharmacology Review, 19, 463-521.
14. Mattox AJ, Picker MJ and Dykstra LA (1994) Pharmacological analysis of the rate-decreasing effects of mu and kappa opioids in pigeons. Psychopharmacology, 113, 457-462.
15. McMillan DE, Wolf PS and Carchman RA (1970) Antagonism of the behavioral effects of morphine and methadone by narcotic antagonists in the pigeon. Journal of Pharmacology and Experimental Therapeutics, 175, 443-458.
16. Moerschbaecher JM, Devia C and Brocklehurst C (1988) Differential antagonism by naltrexone of the effects of opioids on a fixed-ratio discrimination in rats. Journal of Pharmacology and Experimental Therapeutics, 244, 237-246.
17. Negus SS, Burke TF, Medzhiradsky F and Woods JH (1993) Effects of opioid agonists selective for mu, kappa, and delta opioid receptors on schedule-controlled responding in rhesus monkeys: antagonism by quadazocine. Journal of Pharmacology and Experimental Therapeutics, 267, 897-903.
18. Picker MJ (1991) Discriminative stimulus properties of (+)- and (-)-n allylnormetazocine: the role of training dose in the stimulus substitution patterns produced by PCP/sigma and mixed-action opioid compounds. Behavioural Pharmacology, 2, 497-511.
19. Picker MJ (1994) Discriminative stimulus and response rate-decreasing effects of kappa opioids: antagonism by naloxone. Life Sciences, 54, 1767-1775.
20. Picker MJ and Yarbrough J (1991) Cross-tolerance and enhanced sensitivity to the response rate-decreasing effects of opioids with varying degrees of intrinsic efficacy at the mu receptor. Psychopharmacology, 105, 459-466.
21. Picker MJ, Yarbrough J, Hughes CE, Smith MA, Morgan D and Dykstra LA (1993) Agonist and antagonist effects of mixed action opioids in the pigeon drug discrimination procedure, influence of training dose, intrinsic efficacy and interanimal differences. Journal of Pharmacology and Experimental Therapeutics, 266, 756-767.
22. Pitts RC and Dykstra LA (1994) Antinociceptive and response rate-altering effects of kappa opioid agonists, spiradoline, enadoline and U69,593, alone and in combination with opioid antagonists in squirrel monkeys. Journal of Pharmacology and Experimental Therapeutics, 271, 1501-1508.
23. Shannon HE and Holtzman SG (1979) Morphine training dose: a determinant of stimulus generalization to narcotic antagonists in the rat. Psychopharmacology, 61, 239-244.
24. Smith MA and Picker MJ (1995) Examination of the kappa agonist and antagonist properties of opioids in the rat drug discrimination procedure: influence of training dose and intrinsic efficacy. Behavioural Pharmacology, 6, 703-717.
25. Smits SE and Takemori AE (1970) Quantitative studies on the antagonism by naloxone of some narcotic and narcotic-antagonist analgesics. British Journal of Pharmacology, 39, 627-638.
26. Tallarida RJ and Murray RB (1987) Manual of Pharmacological Calculations with Computer Programs. Springer-Verlag, New York.
27. Vanecek SA and Young AM (1995) Pharmacological characterization of an operant discrimination among two doses of morphine and saline in pigeons. Behavioural Pharmacology, 6, 669-681.
28. Von Voigtlander PF, Lahti RA and Ludens JH (1983) U50,488: a selective and structural novel non-mu (kappa) opioid agonist. Journal of Pharmacology and Experimental Therapeutics, 224, 7-12.
29. 2 analysis of naltrexone antagonism of discriminative and analgesic effects of opiate agonists in rats. Journal of Pharmacology and Experimental Therapeutics, 271, 959-968.
30. Ward SJ and Takemori AE (1983) Relative involvement of mu, kappa, and delta receptor mechanisms in opiate-mediated antinociception in mice. Journal of Pharmacology and Experimental Therapeutics, 224, 525-530.
31. Woods JH and Winger G (1987) Opioids, receptors, and abuse liability. In: Psychopharmacology: The Third Generation of Progress (Ed HY Meltzer), pp. 1555-1564. Raven Press, New York.
32. 2 analysis in assessment of opioid abuse liability. Trends in Pharmacological Sciences, 13, 282-286.
33. Young AM and Woods JH (1982) Limitations on the antagonistic actions of opioid antagonists. Federation Proceedings, 41, 2333-2338.
34. Young AM and Stephens KR (1984) Antagonism of the discriminative effects of ethylketazocine, cyclazocine, and nalorphine in macaques. Psychopharmacology, 84, 356-361.
35. Young AM, Masaki MA and Geula C (1992) Discriminative stimulus effects of morphine: effects of training dose on agonist and antagonist effects of mu opioids. Journal of Pharmacology and Experimental Therapeutics, 261, 246-257.