Synergetic cytotoxicity of bleomycin and polyhydric alcohols: DNA strand breakage evaluated by "comet assay"

Biological and Pharmaceutical Bulletin

Volumn 19, Issue 4, 1996, Pages 632-635

  Kasamatsu, Toshio ^a   Kohda, Kohfuku ^a   Kawazoe, Yutaka ^a  

^a NAGOYA CITY UNIVERSITY   (Japan)

Author keywords

Bleomycin; Comet assay; DNA strand break

Indexed keywords

ALCOHOL; ALCOHOL DERIVATIVE; BLEOMYCIN; GLYCEROL; GLYCOPEPTIDE; MACROGOL; METHANOL;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL POPULATION; CELL PROTECTION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOTOXICITY; DNA STRAND BREAKAGE; DOSE RESPONSE; DRUG POTENTIATION; HAMSTER; NONHUMAN;

ALCOHOLS; ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; BLEOMYCIN; CELL LINE; CELL SURVIVAL; DNA DAMAGE; DRUG SYNERGISM; ELECTROPHORESIS, AGAR GEL; GLYCEROL; INDOLES; MICROSCOPY, FLUORESCENCE; POLYVINYL ALCOHOL;

EID: 0030006298     PISSN: 09186158     EISSN: None     Source Type: Journal    
DOI: 10.1248/bpb.19.632     Document Type: Article

References (10)

1. Suzuki T., Kohda K., Kawazoe Y., Chem. Pharm. Bull., 36, 1611 (1988).
2. Suzuki T., Kohda K., Kawazoe Y., Anticancer Res., 10,97(1990).
3. Wu J. C., Kozarich J. W., Stubbe J., J. Biol. Chem., 258, 4694 (1983).
4. Östling O., Johanson K. J., Biochem. Biophys. Res. Commun., 123, 291 (1984).
5. McKelvey-Martin V. J., Green M. H. L., Schmezer P., Pool-Zobel B. L., De Méo M. P., Collins A., Mutat. Res., 288. 47 (1993).
6. Fairbairn D. W., Olive P. L., O'Neill K. L., Mutat. Res., 339, 37 (1995).
7. Kasamastu T., Kohda K., Kawazoe Y., Mutation Res., in press (1996).
8. Kasamastu T., Kohda K., Kawazoe Y., Anticancer Res., in press (1996).
9. Poddevin B., Orlowski S., Belehradek J. Jr., Mir L. M., Biochem. Pharmacol., 42, S67 (1991).
10. Tounekti O., Pron G., Belehradek J. Jr., Mir L. M., Cancer Res., 53, 5462 (1993).