Metabolism of barnidipine hydrochloride, a potent calcium antagonist, in rat and dog

Xenobiotica

Volumn 26, Issue 2, 1996, Pages 177-187

  Teramura, T ^a   Tokunaga, T ^a   Matsumoto, H ^a   Watanabe, T ^a   Higuchi, S ^a  

^a ASTELLAS PHARMA INC   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ANTAGONIST; DRUG METABOLITE; MEPIRODIPINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BILIARY EXCRETION; CONTROLLED STUDY; DOG; DRUG METABOLISM; INTESTINE; KIDNEY; LIVER MICROSOME; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; RAT; URINARY EXCRETION;

ANIMALIA; CANIS FAMILIARIS;

EID: 0030006152     PISSN: 00498254     EISSN: None     Source Type: Journal    
DOI: 10.3109/00498259609046698     Document Type: Article

References (19)

1. BERESFORD, A. P., MACRAE, P. V., and STOPHER, D. A., 1988, Metabolism of amlodipine in the rat and dog, a species difference. Xenobiotica, 18, 169-182.
2. GUENGERICH, F. P., 1987, Oxidative cleavage of carboxylic esters by cytochrome P-450. Journal of Biological Chemistry, 262, 8459-8462.
3. GUENGERICH, F. P., and BOCKER, R. H., 1988a, Cytochrome P-450-catalyzed dehydrogenation of 1,4-dihydropyridines. Journal of Biological Chemistry, 263, 8168-8175.
4. GUENGERICH, F. P., MARTIN, M. V., BEAUNE, P. H., KREMERS, P., WOLFF, T., and WAXMAN, D. J. 1986, Characterization of rat and human liver microsomal cytochrome P-450 forms involved in nifedipine oxidation, a prototype for genetic polymorphism in oxidative drug metabolism. Journal of Biological Chemistry, 261, 5051-5060.
5. GUENGERICH, F. P., PETERSON, L. A. and BOCKER, R. H. 1988b, Cytochrome P-450-catalyzed hydroxylation and carboxylic acid ester cleavage of Hantzsch pyridine esters. Journal of Biological Chemistry, 263, 8176-8183.
6. HIGUCHI, S., SASAKI, V., SHIOBARA, Y., and SADO, T., 1977, Absorption, excretion and metabolism of a new dihydropyndine diester cerebral vasodilator in rats and dogs. Xenobiotica, 7, 469-479.
7. HIGUCHI, S., and SHIOBARA, Y., 1980, Metabolic fate of nicardipine hydrochloride, a new vasodilator, by various species in vitro. Xenobiotica, 10, 889-896.
8. KOBAYASHI, H., OKUMURA, S., KOSAKA, Y., KOBAYASHI, S., INOUE, A., OKA, T., and MAKAMIZO, N., 1988, Identification of benidipine hydrochloride metabolites in rats and dogs. Arzneimittel-Forschung/Drug Research, 38, 1753-1756.
9. KONDO, S., KUCHIKI, A., YAMAMOTO, K., AKIMOTO, K., TAKAHASHI, K., AWATA, N., and SUGIMOTO, I., 1980, Identification of nifedipine metabolites and their determination by gas chromatography. Chemical & Pharmaceutical Bulletin, 28, 1-7.
10. MEYER, H., SCHERLING, D., and KARL, W., 1983a, Nitrendipine: identification and synthesis of main metabolites. Arzneimittel-Forschung/Drug Research, 33, 1528-1534.
11. MEYER, H., WEHINGER, E., BOSSERT, F., and SCHERLING, D., 1983b, Nimodipine: Synthesis and metabolic pathway. Arzneimittel-Forschung/Drug Research, 33, 106-112.
12. NELSON, D. R., KAMATAKI, T., WAXMAN, D. J., GUENGERICH, F. P., ESTABROOK, R. W., FEYEREISEN, R., GONZALEZ, F. J., COON, M. J., GUNSALUS, I. C., GOTOH, O., OKUDA, K., and NEBERT, D. W., 1993, The P450 superfamily: Update on new sequences, gene mapping, accession numbers, early trivial names of enzymes, and nomenclature. DNA and Cell Biology, 12, 1-51.
13. NIWA, T., TOKUMA, Y., and NOGUCHI, H., 1988, Oxidation of nilvadipine, a new dihydropyridine calcium antagonist, to the corresponding pyridine by rat liver microsomes. Xenobiotica, 18, 217-224.
14. TAMAZAWA, K., ARIMA, H., KAJIMA, T., ISOMURA, Y., OKADA, M., FUJITA, S., FURUYA, T., TAKENAKA, T., INAGAKI, O., and TERAI, M., 1986, Stereoselectivity of a potent calcium antagonist, 1-benzyl-3-pyrrolidinyl methyl 2,6-dimethyl-4-(m-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate. Journal of Medical Chemistry, 29, 2504-2511.
15. TERAMURA, T., KOBAYASHI, S., and HIGUCHI, S., 1993, Metabolism of barnidipine hydrochloride in rats, dogs and humans. Abstract published in Proceedings of the 5th European International Society for the Study of Xenobiotics Meeting, Tours, France, abstract, pp. 103.
16. TERASHITA, S., TOKUMA, Y., FUJIWARA, T., SHIOKAWA, Y., OKUMURA, K., and NOGUCHI, H., 1987, Metabolism of nilvadipine, a new dihydropyridine calcium antagonist, in rats and dogs. Xenobiotica, 17, 1415-1425.
17. TRIGGLE, D. J., 1982, In Calcium Blockers: Mechanism of action and clinical applications, edited by S. F. Flaim and R. Zelis (Baltimore: Urban & Schwarzenberg), pp. 121.
18. WEIDOLF, L., BORG, K. O., and HOFFMAN, K. J., 1984, Urinary metabolites of felodipine, a new vasodilator drug, in man, rat and mouse. Xenobiotica, 14, 657-666.
19. YOSHIDA, K., MITSUYA, M., TSUKAMOTO, T., HISAKA, H., KOBAYASHI, T., and TANAYAMA, K., 1989, Metabolism of manidipine hydrochloride [CV-4093 (2HCl)], a new calcium antagonist, in rats and dogs. Japanese Pharmacology and Therapeutics, 17, 249-265.