Baroreflex resetting but no vascular tolerance in response to transdermal glyceryl trinitrate in conscious rabbits

British Journal of Pharmacology

Volumn 118, Issue 1, 1996, Pages 93-104

  Serone, Adrian P ^a   Angus, James A ^a   Wright, Christine E ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Baroreceptor reflex resetting; Glyceryl trinitrate; Nitrate tolerance; Reactive hyperaemia; Vascular reactivity

Indexed keywords

ACETYLCHOLINE; ADENOSINE; GLYCERYL TRINITRATE; METHOXAMINE; N ACETYL S NITROSOPENICILLAMINE; VASODILATOR AGENT;

ABDOMINAL AORTA; ANIMAL EXPERIMENT; ARTICLE; BLOOD VESSEL REACTIVITY; CONTROLLED STUDY; DOSE RESPONSE; DRUG TOLERANCE; FEMALE; HEART RATE; HEMODYNAMICS; HYPEREMIA; INTRAARTERIAL DRUG ADMINISTRATION; LONG TERM CARE; MALE; MEAN ARTERIAL PRESSURE; NONHUMAN; PRESSORECEPTOR REFLEX; PRIORITY JOURNAL; RABBIT; TRANSDERMAL DRUG ADMINISTRATION;

EID: 0030005987     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1476-5381.1996.tb15371.x     Document Type: Article

References (60)

1. AHLNER, J., ANDERSSON, R.G.G., TORFGARD, K. & AXELSSON, K.L. (1991). Organic nitrate esters: clinical use and mechanisms of actions. Pharmacol. Rev., 43, 351-423.
2. ANGUS, J.A. & BRAZENOR, R.M. (1983). Relaxation of large coronary artery by verapamil, D600 and nifedipine is constrictor selective: comparison with glyceryl trinitrate. J. Cardiovasc. Pharmacol., 5, 321-328.
3. ANGUS, J.A., SATOH, K. & COCKS, T.M. (1986). Selectivity of calcium antagonists on canine large and small coronary arteries. In II Asian Pacific Adalat Symposium. ed. Kelly, D.T. pp.12-27. Auckland: Adis Press.
4. ARMSTRONG, P.W. & MOFFAT, J.A. (1983). Tolerance to organic nitrates: clinical and experimental perspectives. Am. J. Med., 74, 73-84.
5. BAUER, J.A. & FUNG, H. (1990). Effects of chronic glyceryl trinitrate on left ventricular haemodynamics in a rat model of congestive heart failure: demonstration of a simple animal model for the study of in vivo nitrate tolerance. Cardiorasc. Res., 24, 198-203.
6. BEAUFORT-KROL, G.C., SUICHIES, H.E., AARNOUDES, J.G., OKKEN, A., JENTINK, H.Q. & GREVE, J. (1989). Postocclusive reactive hyperaemia of cutaneous blood flow in premature newborn infants. Acta Paediatr. Scand. Suppl., 350, 20-25.
7. +-channel openers, and nicorandil on large and small coronary arteries in conscious dogs. J. Cardiovasc. Pharmacol., 20 (Suppl 3), S17-S21.
8. BOESGAARD, S., ALDERSHVILLE, J., POULSEN, H., LOFT, S., ANDERSON, M.E. & MEISTER, A. (1994). Nitrate tolerance in vivo is not associated with depletion of arterial or venous thiol levels. Circ. Res., 74, 115-120.
9. BROWN, I.P., THOMPSON, C.I. & BELLONI, F.L. (1993). Role of nitric oxide in hypoxic coronary vasodilation in isolated perfused guinea pig heart. Am. J. Physiol., 264, H821-H829.
10. CHEESMAN, A.R. & BENJAMIN, N. (1994). Lack of tolerance in forearm blood vessels in man to glyceryl trinitrate. Br. J. Clin. Pharmacol., 37, 441-444.
11. CLOAREC-BLANCHARD, L., FUNCK-BRENTANO, C., CARAYON, A. & JAILLON, P. (1994). Rapid development of nitrate tolerance in healthy volunteers: assessment using spectral analysis of short-term blood pressure and heart rate variability. J. Cardiovasc. Pharmacol., 24, 266-273.
12. CURRY, S.H., KWON, H.K., PERRIN, J.H., CULP, J.R., PEPINE, C.J., YU, W.C. & STEVENS, J.L. (1984). Plasma nitroglycerin concentrations and hemodynamic effects of sublingual, ointment, and controlled-release forms of nitroglycerin. Clin. Pharmacol. Ther., 36, 765-772.
13. DORWARD, P.K., ANDRESEN, M.C., BURKE, S.L., OLIVER, J.R. & KORNER, P.I. (1982). Rapid resetting of the aortic baroreceptors in the rabbit and its implications for short-term and longer term reflex control. Circ. Res.. 50, 428-439.
14. DU, Z.Y., DUSTING, G.J. & WOODMAN, O.L. (1991). Effect of tolerance to glyceryl trinitrate on vascular responses in conscious rabbits. Clin. Exp. Pharmacol. Physiol., 18, 439-447.
15. DUPUIS, J., LALONDE, G., LEMIEUX, R. & ROULEAU, J.L. (1990). Tolerance to intravenous nitroglycerin in patients with congestive heart failure: role of increased intravascular volume, neurohumoral activation and lack of prevention with N-acetylcysteine. J. Am. Coll. Cardiol., 16, 923-931.
16. EBRIGHT, G.E. (1914). The effects of nitroglycerin on those engaged in its manufacture. J. Am. Med. Assoc., 62, 201-202.
17. ECKBERG, D.L. & SLEIGHT, P. (1992). Human Buroreflexes in Health and Disease. New York: Oxford University Press.
18. FÖRSTER, S., WODITSCH, I., SCHRÖDER, H. & SCHRÖR, K. (1991). Reduced nitric oxide release causes nitrate tolerance in the intact coronary circulation. J. Cardiovasc. Pharmacol., 17, 867-872.
19. GHIO, S., DE SERVI, S., PEROTTI, R., ELEUTERI, E., MONTEMARTINI, C. & SPECCHIA, G. (1992). Different susceptibility to the development of nitroglycerin tolerance in the arterial and venous circulation in humans. Circulation, 86, 798-802.
20. HAYWOOD, J.R., SHAFFER, R.A., FASTENOW, C., FINK, G.D. & BRODY, M.J. (1981). Regional blood flow measurements with pulsed Doppler flowmeter in conscious rat. Am. J. Physiol., 241, H273-H278.
21. HE, G.-W., ROSENFELDT, F.L., BUXTON, B.F. & ANGUS, J.A. (1989). Reactivity of human isolated internal mammary artery to constrictor and dilator agents- implications for treatment of internal mammary artery spasm. Circulation, 80, (suppl I) 1141-1150.
22. HEAD, G.A. & McCARTY, R. (1987). Vagal and sympathetic components of the heart rate range and gain of the baroreceptor-heart rate reflex in conscious rats. J. Autonom. Nerv. Syst., 21, 203-213.
23. HENRY, P.J., DRUMMER, O.H. & HOROWITZ, J.D. (1989a). S-nitrosothiols as vasodilators: implications regarding tolerance to nitric oxide-containing vasodilators. Br. J. Pharmacol., 98, 757-766.
24. HENRY, P.J., HOROWITZ, J.D & LOUIS, W.J. (1989b). Determinants of in vitro nitroglycerin tolerance induction and reversal: influence of dose regimen, nitrate-free period, and sulfhydryl supplementation. J. Cardiovasc., 14, 31-37.
25. HENRY, P.J., HOROWITZ, J.D. & LOUIS, W.J. (1989c). Nitroglycerin-induced tolerance affects multiple sites in the organic nitrate bioconversion cascade. J. Pharmacol. Exp. Ther., 248, 762-768.
26. HENRY, P.J., HOROWITZ, J.D. & LOUIS, W.J. (1990). Nitrate tolerance induced by nicorandil or nitroglycerin is associated with minimal loss of nicorandil vasodilator activity. J. Cardiovasc. Pharmacol., 15, 365-370.
27. HERD, J & BARGER, A.C. (1964). Simplified technique for chronic catheterization of blood vessels. J. Appl. Physiol., 19, 791-792.
28. HINTZE, T.H. & VATNER, S.F. (1983). Comparison of effects of nifedipine and nitroglycerin on large and small coronary arteries and cardiac function in conscious dogs. Circ. Res., 52 (Suppl 1), 139-146.
29. HIREMATH, A.N., HOFFMAN, B.B. & BLASCHKE, T.F. (1989). Responsiveness of peripheral veins to transdermal and sublingual nitroglycerin in healthy male volunteers. J. Cardiovasc. Pharmacol., 14, 534-541.
30. HIWATARI M., NOLAN, P.L. & JOHNSTON, C.I. (1985). The contribution of vasopressin and angiotensin to the maintenance of blood pressure after autonomie blockade. Hypertension, 7, 547-553.
31. HOGAN, J.C., LEWIS, M.J. & HENDERSON, A.H. (1990). Chronic administration of N-acetylcysteine to prevent nitrate tolerance in patients with stable angina pectoris. Br. J. Clin. Pharmacol., 30, 573-577.
32. HUSAIN, M., ADRIE, C., ICHINOSE, F., KAVOSI, M. & ZAPOL, W.M. (1994). Exhaled nitric oxide as a marker for organic nitrate tolerance. Circulation, 89, 2498-2502.
33. KALANT, H. (1971). Tolerance to and dependence on some non-opiate psychotropic drugs. Pharmacol. Rev., 23, 135-191.
34. KAMINSKI, P. & WOLIN, M.S. (1993). Hypoxia increases superoxide anion production from bovine coronary microvessels, but not cardiac myocytes, via increased xanthine oxidase. Circulation, 88, I-567.
35. KATZ, R.J., LEVY, W.S., BUFF, L. & WASSERMAN, A.G. (1991). Prevention of nitrate tolerance with angiotensin converting enzyme inhibitors. Circulation, 83, 1271-1277.
36. KODJA, G., BECK, J.K. MEYER, W. & NOACK, E. (1994). Nitrovasodilator-induced relaxation and tolerance development in porcine vena cordis magna: dependence on intact endothelium. Br. J. Pharmacol., 112, 533-540.
37. KODJA, G. & NOACK, E. (1993). Nitric oxide liberating, soluble guanylate cyclase stimulating and vasorelaxing properties of the new nitrate-compound SPM 3672. J. Cardiovasc. Pharmacol., 22, 103-111.
38. KOUSHANPOUR, E. (1991). Baroreceptor discharge behaviour and resetting. In Baroreceptor Reflexes - Integrative Functions and Clinical Aspects. ed. Persson, P.B. & Kirchheim, H.R. pp.9-44. Berlin: Springer-Verlag.
39. KUKOVETZ, W.R. & HOLZMANN, S. (1990). Mechanisms of nitrate-induced vasodilation and tolerance. Eur. J. Clin. Pharmacol., 38 (Suppl 1), S9-S14.
40. LAWS, G.L. (1898). Effects of nitroglycerin on those who manufacture it. J. Am. Med. Assoc., 31, 793.
41. LEVY, W.S., KATZ, R.J. & WASSERMAN, A.G. (1991). Methionine restores the venodilative response to nitroglycerin after the development of tolerance. J. Am. Coll. Cardiol., 17, 474-479.
42. LUDBROOK, J. (1984). Comparison of the reflex effects of arterial baroreceptors and cardiac receptors on the heart rate of conscious rabbits. Clin. Exp. Pharmacol. Physiol., 11, 245-260.
43. LUDBROOK, J. (1994). Repeated measurements and multiple comparisons in cardiovascular research. Candiovasc. Res., 28, 303-311.
44. MOLINA, C.R., ANDRESFN, J.W., RAPOPORT, R.M., WALDMAN, S. & MURAD, F. (1987). Effect of in vivo nitroglycerin therapy on endothelium-dependent and independent vascular relaxation and cyclic GMP accumulation in rat aorta. J. Cardiovasc. Pharmacol., 10, 371-378.
45. NAKASHIMA, A., ANGUS, J.A. & JOHNSTON, C.I. (1982). Comparison of angiotensin converting enzyme inhibitors captopril and MK421-di-acid in guinea-pig atria. Eur. J. Pharmacol., 81, 487-492.
46. NEEDLEMAN, P. & JOHNSON, E.M. (1973). Mechanism of tolerance development to organic nitrates. J. Pharmacol. Exp. Ther., 184, 709-715.
47. NEWMAN, C.M., WARREN, J.B., TAYLOR, G.W., BOOBIS, A.R. & DAVIES, D.S. (1990). Rapid tolerance to the hypotensive effects of glyceryl trinitrate in the rat: prevention by N-acetyl-L but not N-acetyl-D-cysteine. Br. J. Pharmacol., 99, 825-829.
48. PARK, K.H., RUBIN, L.E., GROSS, S.S. & LEVI, R. (1992). Nitric oxide is a mediator of hypoxic coronary vasodilation. Relation to adenosine and cyclooxygenase-derived metabolites. Circ. Res., 71, 992-1001.
49. PARKER, J.D., FARRELL, B., FENTON, T., COHANIM, M. & PARKER, J.O. (1991). Counter-regulatory responses to continuous and intermittent therapy with nitroglycerin. Circulation, 84, 2336-2345.
50. PARKER, J.D. & PARKER, J.O. (1993). Effect of therapy with angiotensin-converting enzyme inhibitor on haemodynamic and counterregulatory responses during continuous therapy with nitroglycerin. J. Am. Coll. Cardiol., 21, 1445-1453.
51. POHL, U., LAMONTAGNE, E. & BUSSE, R. (1994). Attenuation of coronary autoregulation in the rabbit heart by endothelium derived nitric oxide. Cardiovasc. Res., 28, 414-419.
52. REYNOLDS, J.E.F. (1989). Vasodilators. In Martindale - The Extra Pharmacopoeia ed. Reynolds, J.E.F., Parfitt, K., Parsons, A.V. & Sweetman, S.C. pp. 1499-1502. London: The Pharmaceutical Press.
53. SHAFFER, J.E., HAN, B., CHERN, W.H. & LEE, F.W. (1992). Lack of tolerance to a 24 h infusion of S-nitroso N-acetylpenicillamine (SNAP) in conscious rabbits. J. Pharmacol. Exp. Ther., 260, 286-293.
54. SLACK, C.J., McLAUGHLIN, B.E., BRIEN, J.F., MARKS, G.S. & NAKATSU, K. (1989). Biotransformation of glyceryl trinitrate and isosorbide dinitrate in vascular smooth muscle made tolerant to organic nitrates. Can. J. Physiol. Pharmacol., 67, 1381-1385.
55. STEWARD, D.D. (1905). Tolerance to nitroglycerin. J. Am. Med. Assoc., 44, 1678-1679.
56. SUMIMOTO, T., HAMADA, M., KAWAKAMI, H., SUZUKI, M., ABE, M., MATSUOKA, H., SHIGEMATSU, Y. & HIWADA, K. (1993). Effects of glyceryl trinitrate on blood pressure and arterial compliance. Angiology, 44, 951-957.
57. TORFGÅRD, K.E. & AHLNER, J. (1993). Effect of low dose of dipyridamole on glyceryl trinitrate tolerance in healthy volunteers. J. Cardiovasc. Pharmacol., 21, 516-521.
58. WOODCOCK, B.G., MENKE, G. & RIETBROCK, N. (1986). Nitroplasters and bioavailability. Trends Pharmacol. Sci., 7, 338-340.
59. WRIGHT, C.E., ANGUS, J.A. & KORNER, P.I. (1987). Vascular amplifier properties in renovascular hypertension in conscious rabbits. Hypertension, 9, 122-131.
60. ZIMMERMANN, T., LEITOLD, M. & YEATES, R.A. (1991). Comparison of isobutyl nitrate and isobutyl nitrite: tolerance and cross-tolerance to glyceryl trinitrate. Eur. J. Pharmacol., 192, 181-184.