Structure and chromosomal location of the mouse medium-chain acyl-CoA dehydrogenase-encoding gene and its promoter

Gene

Volumn 170, Issue 2, 1996, Pages 165-171

  Tolwania, Ravi J ^a,d   Farmer, Susan C ^a   Johnson, Kenneth R ^b   Davisson, Muriel T ^b   Kurtz, David M ^a   Hinsdale, Myron E ^a,e   Cresci, Sharon ^c   Kelly, Daniel P ^c   Wood, Philip A ^a  

^a UNIVERSITY OF ALABAMA SCHOOL OF MEDICINE   (United States)

^b JACKSON LABORATORY   (United States)

^c WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d STANFORD UNIVERSITY MEDICAL CENTER   (United States)

^e UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

Acadm gene; Fatty acid oxidation; Gene cloning; Nuclear receptor response element; Pseudogenes

Indexed keywords

ACYL COENZYME A DEHYDROGENASE; CELL NUCLEUS RECEPTOR; DNA; STEROID RECEPTOR; THYROID HORMONE RECEPTOR; TRANSCRIPTION FACTOR SP1;

ARTICLE; BINDING SITE; CHROMOSOMAL LOCALIZATION; CONSENSUS SEQUENCE; DNA SEQUENCE; ELECTROPHORETIC MOBILITY; GENE MAPPING; GENE STRUCTURE; INTRON; MOLECULAR CLONING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PSEUDOGENE; SEQUENCE HOMOLOGY;

EID: 0030005955     PISSN: 03781119     EISSN: None     Source Type: Journal    
DOI: 10.1016/0378-1119(95)00882-9     Document Type: Article

References (33)

1. Bahary, N., Zorich, G., Pachter, J.E., Leibel, R.L. and Friedman, J.M.: Molecular genetic linkage maps to mouse chromosome 4 and 6. Genomics 11 (1991) 33-47.
2. Beato, M.: Gene regulation by steroid hormones. Cell 56 (1989) 335-344.
3. Carter, M.E., Gulick, T., Raisher, B.D., Caira, T., Ladias, J.A.A., Moore, D.D. and Kelly, D.P.: Hepatocyte nuclear factor-4 activates medium chain acyl-CoA dehydrogenase gene transcription by interacting with a complex regulatory element. J. Biol. Chem. 268 (1993) 13805-13810.
4. Carter, M.E., Gulick, T., Moore, D.D. and Kelly, D.P.: A pleiotropic element in the medium-chain acyl-coenzyme A dehydrogenase gene promoter mediates transcriptional regulation by multiple nuclear receptor transcription factors and defines novel receptor-DNA binding motifs. Mol. Cell. Biol. 14 (1994) 4360-4372.
5. Copeland, N.G., Jenkins, N.A., Gilbert, D.J., Eppig, J.T., Maltais, L.J., Miller, J.C., Dietrich, W.F., Weaver, A., Lincoln, S.E., Steen, R.G., Stein, L.D., Nadeau, J.H. and Lander, E.S.: A genetic linkage map of the mouse: current applications and future prospects. Science 262 (1993) 57-66.
6. Courey, A.J., Holtzman, D.A., Jackson, S.P. and Tijian, R.: Synergistic activation by the glutamine-rich domains of human transcription factor Sp1. Cell 59 (1989) 827-836.
7. Davis, L.G., Dibner, M.D. and Battey, J.F.: Basic Methods in Molecular Biology. Elsevier, New York, 1986. pp. 193-213.
8. Feinberg, A.P. and Vogelstein, B.: A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. Anal. Biochem. 132 (1983) 6-13.
9. Finocchiaro, G., Ito, M. and Tanaka, K.: Purification and properties of short chain acyl-CoA, medium chain acyl-CoA, and isovaleryl-CoA dehydrogenases from human liver. J. Biol. Chem. 262 (1987) 7982-7989.
10. Gardiner-Garden, M. and Frommer, M.: CpG islands in vertebrate genomes. J. Mol. Biol. 196 (1987) 261-282.
11. Hannink, M. and Temin, H.M.: Structure and autoregulation of the c-rel promoter. Oncogene 5 (1990) 1843-1850.
12. Hernandez, N.: TBP, a universal eukaryotic transcription factor. Genes Dev. 7 (1993) 1291-1308.
13. Hinsdale, M.E., Kelly, C.L. and Wood, P.A.: Null allele at Bcd-1 locus in BALB/cByJ mice is due to a deletion in the short-chain acyl-CoA dehydrogenase gene and results in missplicing of mRNA. Genomics 16 (1993) 605-611.
14. Ikeda, Y., Keese, S.M., Fenton, W.A. and Tanaka, K.: Biosynthesis of four rat liver mitochondrial acyl-CoA dehydrogenases: in vitro synthesis, import into mitochondria, and processing of their precursors in a cell-free system and in cultured cells. Arch. Biochem. Biophys. 252 (1987) 662-674.
15. Johnson, K.R., Cook, S.A. and Davisson, M.T.: Chromosomal localization of the murine gene and two related sequences encoding high-mobility-group I and Y proteins. Genomics 12 (1992) 503-509.
16. Johnson, K.R., Cook, S.A. and Davisson, M.T.: Identification and genetic mapping of 151 dispersed members of 16 ribosomal protein multigene families in the mouse. Mamm. Genome 5 (1994) 670-687.
17. Jorcyk, C.L., Watson, D.K., Mavrothalassitis, G.J. and Papas, T.S.: The human Ets-1 gene: Genomic structure, promoter characterization and alternative splicing. Oncogene 6 (1991) 523-532.
18. Kelly, D.P., Kim, J.-J., Billadello, J.J., Hainline, B.E., Chu, T.W. and Strauss, A.W.: Nucleotide sequence of medium chain acyl-CoA dehydrogenase mRNA and its expression in enzyme-deficient human tissue. Proc. Natl. Acad. Sci. USA 84 (1987) 4068-4072.
19. Kelly, D.P., Gordon, J.I., Alpers, R. and Strauss, A.W.: The tissue-specific expression and developmental regulation of two nuclear genes encoding rat mitochondrial proteins - medium chain acyl-CoA dehydrogenase and mitochondrial malate dehydrogenase. J. Biol. Chem. 264 (1989) 18921-18925.
20. Kidd, J.R., Matsubara, Y., Castiglione, C.M., Tanaka, K. and Kidd, K.K.: The locus for the medium-chain acyl-CoA dehydrogenase gene on chromosome 1 is highly polymorphic. Genomics 6 (1990) 89-93.
21. Larsen, F., Gundersen, G., Lopez, R. and Prydz, H.: CpG islands as gene markers in the human genome. Genomics 13 (1992) 1095-1107.
22. Leone, T.C., Cresci S., Carter, M.E., Zhang, Z., Strauss, A.W. and Kelly, D.P.: The human medium-chain acyl-CoA dehydrogenase (MCAD) gene promoter consists of a complex arrangement of nuclear receptor response elements and Sp1 binding sites. J. Biol. Chem. 270 (1995) 16308-16314.
23. Manly, K.F.: A Macintosh program for storage and analysis of experimental genetic mapping data. Mammal. Genome 4 (1993) 303-313.
24. Nadeau, J.H., Davisson, M.T., Doolittle, D.P., Grant, P., Hillyard, A.L., Kosowsky, M. and Roderick, T.H.: Comparative map for mice and humans. Mammal. Genome 3 (1992) 480-536.
25. Nasrin, N., Ercolani, L., Denaro, M., Kong, X.F., Kang, I. and Alexander, M.: An insulin response element in the glyceraldehyde-3-phosphate dehydrogenase gene binds a nuclear protein induced by insulin in cultured cells and by nutritional manipulations in vivo. Proc. Natl. Acad. Sci. USA 87 (1990) 5273-5277.
26. Raisher, B.D., Gulick, T., Zhang, Z., Strauss, A.W., Moore, D.D. and Kelly, D.P.: Identification of a novel retinoid-response element in the promoter region of the medium chain acyl-coenzyme A dehydrogenase gene. J. Biol. Chem. 267 (1992) 20264-20269.
27. Roe, C.R. and Coates, P.M.: Mitochondrial fatty acid oxidation disorders. In: Scriver, C.R., Beaudet, A.L., Sly, W.S. and Valle, D. (Eds.), The Metabolic and Molecular Bases of Inherited Disease. McGraw-Hill, New York, NY, 1995. pp.1501-1533.
28. Smale, S.T. and Baltimore, D.: The 'Initiator' as a transcriptional control element. Cell 57 (1989) 103-113.
29. Smith, J.R., Osborne, T.F., Goldstein, J.L. and Brown, M.S.: Identification of nucleotide responsible for enhancer activity of sterol regulatory element in low density lipoprotein receptor gene. J. Biol. Chem. 265 (1990) 2306-2310.
30. Tolwani, R.J., Farmer, S.C. and Wood, P.A.: Molecular cloning and characterization of the mouse medium-chain acyl-CoA dehydrogenase cDNA. Genomics 23 (1994) 247-249.
31. Williams, T. and Tijian, R.: Analysis of the DNA-binding and activation properties of the human transcription factor Ap2. Genes Dev. 5 (1991) 670-682.
32. Wood, P.A., Farmer, S.C., Tolwani, R.J., Warren, J.R., Steinkampf, M.P., Johnson, L.R., Mountz, J.D. and Kelly, D.P.: Molecular studies of mouse medium-and long-chain acyl-CoA dehydrogenase genes for site-directed mutagenesis of embryonic stem cells. In: Coates, P.M. and Tanaka, K. (Eds.), New Developments in Fatty Acid Oxidation. Wiley-Liss, New York, NY, 1992, pp. 151-160.
33. Zhang, Z., Kelly, D.P., Kim, J.-J., Zhou, Y., Ogden, M.L., Whelan, A.J. and Strauss, A.W.: Structural organization and regulatory regions of the human medium-chain acyl-CoA dehydrogenase gene. Biochemistry 31 (1992) 81-89.