Effect of beraprost sodium (procylin™), a stable prostaglandin I2 analogue, on a dorsal skin flap model in rats

Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery

Volumn 30, Issue 1, 1996, Pages 17-22

  Alexandrou, Konstantinos ^a   Hata, Yuiro ^a   Matsuka, Kazunori ^a   Matsuda, Hidenori ^a  

^a KAGAWA UNIVERSITY   (Japan)

Author keywords

Beraprost sodium; Prostacyclin; Skin flap

Indexed keywords

BERAPROST; PROSTACYCLIN DERIVATIVE; VASODILATOR AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG STRUCTURE; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; NONHUMAN; RAT; SKIN FLAP SURVIVAL;

ANIMALS; BLOOD PRESSURE; EPOPROSTENOL; GRAFT SURVIVAL; HEART RATE; MALE; PLATELET AGGREGATION INHIBITORS; RATS; RATS, SPRAGUE-DAWLEY; SURGICAL FLAPS; VASODILATOR AGENTS;

EID: 0030005697     PISSN: 02844311     EISSN: None     Source Type: Journal    
DOI: 10.3109/02844319609072399     Document Type: Article

References (26)

1. 2 analogue. Br J Pharmacol 1986; 89: 703-711.
2. Belch JJF, McKay A, McArdle B et al. Epoprostenol (prostacyclin) and severe arterial disease: a double blind trial. Lancet 1983; I: 315-317.
3. 2) in aqueous solutions. Prostaglandins 1978; 15: 943-954.
4. Crabb DJ, Niall M, Knight K, Angus J, O'Brien B. Topical use of prostacyclin in microvascular surgery. Br J Plast Surg 1985; 38: 383-388.
5. El Tahir KEH, Williams KI, Betteridge DJ. Differences in the stability of prostacyclin in human, rabbit and rat plasma. Prostaglandins Leukot Med 1983; 10: 109-114.
6. Emerson DJM, Sykes PJ. The effect of prostacyclin on experimental random pattern flaps in the rat. Br J Plast Surg 1981; 34: 264-266.
7. Galla T, Saetzler RKE, Hammersen F, Messmer K. Increase in skin flap survival by the vasoactive drug Buflomedil. Plast Reconstr Surg 1991; 87: 130-136.
8. Hammond D, Brooksher R, Mann R, Beernink J. The dorsal skin flap model in the rat: Factors influencing survival. Plast Reconstr Surg 1993; 91: 316-321.
9. Higgs GA, Higgs EA, Salmon JA. Prostacyclin in inflammation. In: Vane JR, Bergstrom S, eds. Prostacyclin. New York: Raven Press, 1979: p. 187-193.
10. Knight K, Crabb DJ, Niall M et al. Pharmacologic modification of blood flow in the rabbit with prostacyclin and related drugs. Plast Reconstr Surg 1985; 75: 692-700.
11. Moncada S, Gryglewski R, Bunting S, Vane JR. An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation. Nature 1976; 263: 663-665.
12. Murata T, Murai T, Kanai T et al. General Pharmacology of Beraprost Sodium. 2nd communication: Effect on the autonomic, cardiovascular and gastrointestinal systems and other effects. Arzneimittelforschung Drug Res 1989; 39: 867-876.
13. Nickolson RC, Town MH, Vorbruggen H. Prostacyclin-analogs. Med Res Rev 1985; 5: 1-53.
14. Nishio S, Matsuura H, Kanai N et al. The in vitro and ex vivo antiplatelet effect of TRK-100, a stable prostacyclin analog in several species. Jpn J Pharmacol 1988; 47: 1-10.
15. Nishio S, Yamada N, Endoh T et al. Effect of Beraprost Sodium on peripheral circulatory disturbances induced by various stimuli. Arzneimittelforschung Drug Res 1989; 39: 1229-1234.
16. Ohno K, Nagase H, Matsumoto K, Nishiyama H, Nishio S. Stereoselective synthesis of 5,6,7-trinor-4,8-inter-m-phenylene-PG12 derivatives and their inhibitory activities to human platelet aggregation. Adv Prostaglandin Thromboxane Leukot Res 1985; 15: 279-281.
17. Sasaki G, Pang CY. Experimental evidence for involvement of prostaglandins in viability of actue flaps: Effects on viability and mode of action. Plast Reconstr Surg 1981; 67: 335-340.
18. Sim AK, McCraw AP, Cleland ME, Nishio S, Umetsu T. The effect of a stable prostacyclin analogue on platelet function and experimentally induced thrombosis in the microcirculation. Arzneimittelforschung Drug Res 1985; 35: 1816-1818.
19. Simpson PJ, Mitsos SE, Ventura A et al. Prostacyclin protects ischemic reperfused myocardium in the dog by inhibition of neutrophil activation. Am Heart J 1987; 113: 129-137.
20. Sinzinger H, Silberbauer K, Horsch AK, Gall A. Decreased sensitivity of human platelets to PG12 during long term intraarterial prostacyclin infusion in patients with peripheral vascular disease A rebound phenomenon? Prostaglandins 1981; 21: 49-51.
21. Smith RJ, Birndorf M, Gluck BSG et al. The effect of low energy laser on skin flap survival in the rat and porcine models. Plast Reconstr Surg 1992; 89: 306-310.
22. Sturzebecher S, Harberey M, Mullar B et al. Pharmacological profile of a novel carbacyclin derivative with high metabolic stability and oral activity in the rat. Prostaglandins 1986; 31: 95-109.
23. Umetsu T, Murata T, Tanaka Y, Osada E, Nishio S. Antithrombotic effect of TRK-100, a novel, stable PG12 analogue. Jpn J Pharmacol 1987; 43: 81-90.
24. Umetsu T, Murata T, Nishio S. Studies on the antiplatelet effect of the stable epoprostenol analogue beraprost sodium and its mechanism of action in rats. Arzneimittelforschung Drug Res 1989; 39: 68-73.
25. Vedder NB, Bucky LP, Richey N et al. Improved survival rates of random flaps in rabbits with a monoclonal antibody that blocks leukocyte adherence. Plast Reconstr Surg 1994; 93: 1035-1040.
26. Zachary LS, Heggens JP, Robson MC, Murphy RC. Combined prostacyclin and thromboxane synthetase inhibitor UK-38 485 in flap survival. Ann Plast Surg 1986; 17: 112-115.