Red blood cell antioxidant enzymes in age-related macular degeneration

British Journal of Ophthalmology

Volumn 80, Issue 5, 1996, Pages 445-450

  De La Paz, Monica A ^a,b   Zhang, Jian ^a   Fridovich, Irwin ^a  

^a DUKE UNIVERSITY   (United States)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANT; CATALASE; GLUCOSE 6 PHOSPHATE DEHYDROGENASE; GLUTATHIONE PEROXIDASE; GLUTATHIONE REDUCTASE; HEMOGLOBIN; SUPEROXIDE DISMUTASE;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; ENZYME ACTIVITY; ERYTHROCYTE; FEMALE; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MALE; MULTIPLE REGRESSION; PATHOGENESIS; PRIORITY JOURNAL; RETINA MACULA AGE RELATED DEGENERATION;

EID: 0030005581     PISSN: 00071161     EISSN: None     Source Type: Journal    
DOI: 10.1136/bjo.80.5.445     Document Type: Article

References (19)

1. National Advisory Eye Council. Vision research, a national plan: 1983-1987, Vol 1. Report of the Retinal and Choroidal Diseases Panel. Bethesda, MD: National Institutes of Health, NIH Publication No 83-2471.
2. Pryor WA. The free radical theory of aging revisited: a critique and a specific disease-specific theory. In: Butler RN, Sprott RL, Schneider EL, eds. Modern biological theories of aging. New York: Raven Press, 1987: 42-63.
3. Young RW. Solar radiation and age-related macular degeneration. Surv Ophthalmol 1988; 32: 252-69.
4. De La Paz MA, Anderson RE. Regional and age-dependent variation in susceptibility of the human retina to lipid peroxidation. Invest Ophthalmol Vis Sci 1992; 33: 3497-9.
5. Gottsch JD, Pou S, Bynoe LA, Rosen GM. Hematogenous photosensitization: a mechanism for the development of age-related macular degeneration. Invest Ophthalmol Vis Sci 1990; 31: 1674-82.
6. West S, Vitale S, Hallfrisch J, Muñoz B, Muller D, Bressler S, et al. Are antioxidants or supplements protective for age-related macular degeneration? Arch Ophthalmol 1994; 112: 222-7.
7. Seddon JM, Ajani UA, Sperduto RD, Hiller R, Blair N, Burton TC, et al. Dietary carotenoids, vitamins A, C, and E, and advanced age-related macular degeneration. JAMA 1994; 272: 1413-20.
8. Cohen SM, Olin KL, Feuer WJ, Hjelmeland L, Keen CL, Morse LS. Low glutathione reductase and peroxidase activity in age-related macular degeneration. Br J Ophthalmol 1994; 78: 791-4.
9. Prashar S, Pandav SS, Gupta A, Nath R. Antioxidant enzymes in RBSc as a biological index of age-related macular degeneration. Arch Ophthalmol 1993; 71: 214-8.
10. Age-Related Eye Disease Study. Manual of procedures. National Eye Institute, 1992.
11. Mahoney JJ, Vreman HJ, Stevenson DK, Van Kessel AL. Measurement of carboxyhemoglobin and total hemoglobin by five spectrophotometers (CO-oximeters) in comparison with reference methods. Clin Chem 1993; 39: 1693-700.
12. McCord JM, Fridovich I. The reduction of cytochrome c by milk xanthine oxidase. J Biol Chem 1968; 243: 5753-60.
13. Beers RF, Sizer IW. A spectrophotometric method for measuring the breakdown of hydrogen peroxide by catalase. J Biol Chem 1952; 195: 133-40.
14. Kirkman HN. Glucose-6-phosphate dehydrogenase from human erythrocytes. J Biol Chem 1962; 237: 2364-70.
15. Paglia DE, Valentine WN. Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J Lab Clin Med 1967; 70: 158-69.
16. Fliesler SJ, Anderson RE. Chemistry and metabolism of lipids in the vertebrate retina. In: Holman RT, ed. Progress in lipids research, Vol 22. Elmsford, NY: Pergamon Press, 1983: 79-131.
17. Bressler SB, Maguire MG, Bressler NM, Fine SL. Relationship of drusen and abnormalities of the retinal pigment epithelium to the prognosis of neovascular macular degeneration. Arch Ophthalmol 1990; 108: 1442-7.
18. Stevens C, Goldblatt MJ, Freedman JC. Lack of erythrocyte superoxide dismutase change during human senescence. Mech Ageing Devel 1975; 4: 415-21.
19. De La Paz MA, Zhang J, Fridovich I. Antioxidant enzymes of the human retina: effect of age on enzyme activity of macula and periphery. Exp Eye Res (in press).