Amelioration of bleomycin-induced pulmonary injury by cyclosporin A

Experimental Lung Research

Volumn 22, Issue 3, 1996, Pages 337-349

  Lossos, Izidore S ^a   Or, Reuven ^a,b   Goldstein, Ronald H ^b   Conner, Michael W ^b   Breuer, Raphael ^a,b  

^a HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^b BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

bleomycin; cyclosporin A; hamster; interstitial lung disease

Indexed keywords

BLEOMYCIN; COLLAGEN; CYCLOSPORIN A; HYDROXYPROLINE; IMMUNOSUPPRESSIVE AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG SCREENING; HAMSTER; HISTOPATHOLOGY; INTRAPERITONEAL DRUG ADMINISTRATION; LUNG INJURY; LUNG LAVAGE; MALE; NONHUMAN; PNEUMONIA; PRIORITY JOURNAL;

EID: 0030005392     PISSN: 01902148     EISSN: None     Source Type: Journal    
DOI: 10.3109/01902149609031779     Document Type: Article

References (34)

1. Crystal RG. Interstitial lung disease. In: Wyngaarden JR, Smith LH Jr, eds. The Cecil Textbook of Medicine, 19th ed. Philadelphia: WB Saunders; 1991:421-485.
2. Snider GL, Celli BR, Goldstein RH, O'Brien JJ, Lucey EC. Chronic interstitial pulmonary fibrosis produced in hamsters by endotracheal bleomycin. Am Rev Respir Dis. 1978;117:289-297.
3. Thrall RS, McCormick JR, Jack RM, McReynolds RA, Ward PA. Bleomycin-induced pulmonary ribrosis in the rat. Inhibition by indomethacin. Am J Pathol. 1979;95:117-130.
4. Phan SH, Thrall RS, Williams C. Bleomycin-induced pulmonary ribrosis: effects of steroid on lung collagen metabolism. Am Rev Respir Dis. 1981;124:428-434.
5. Chandler DB, Hyde DM, Giri SN. Morphometric estimates of infiltrative cellular changes during the development of bleomycin-induced pulmonary fibrosis in hamsters. Am J Pathol. 1983;112:170-177.
6. Thrall RS, Barton RW. A comparison of lymphocyte populations in lung tissue and in bronchoalveolar lavage fluid of rats at various times during the development of bleomycin-induced pulmonary fibrosis. Am Rev Respir Dis. 1984;129:279-283.
7. Thrall RS, Barton RW, D'Amato DA, Sulavik SB. Differential cellular analysis of bronchoalveolar lavage fluid obtained at various stages during the development of bleomycin-induced pulmonary fibrosis in the rat. Am Rev Respir Dis. 1982;126:488-492.
8. Sigiura Y, Kikuchi T. Formation of superoxide and hydroxy radicals in iron (II)-bleomycin-oxygen system: electron spin resonance detection by spin trapping. J Antibiot. 1978;31:1310-1312.
9. Thrush MA, Mimnaugh ES, Ginsburg E, Gram TE. Studies on the interaction of bleomycin A2 with rat lung microsomes, II: involvement of adventitious iron and reactive oxygen in bleomycin-mediated chain breakage. J Pharmacol Exp Ther. 1982;221:159-165.
10. Tom WM, Montgomery MR. Bleomycin toxicity: alterations in oxidative metabolism in lung and liver microsomal fractions. Biochem Pharmacol. 1980;29:3239-3244.
11. Wahl SM, Wahl LM, McCarthy LB. Lymphocyte-mediated activation of fibroblast proliferation and collagen production. J Immunol. 1978;121:942-946.
12. Johnson RL, Ziff M. Lymphocyte stimulation of collagen accumulation. J Clin Invest. 1979;58:240-248.
13. Thrall RS, McCormick JR, Phan SH, Jack RH, Ward PA. The effect of antilymphocyte globulin on the development of bleomycin-induced pulmonary nbrosis in the rat (abstr). Am Rev Respir Dis. 1979;119(suppl):83.
14. Thrall RS, Lovett EJ III, Barton RW, McCormick JR, Phan SH, Ward PA. The effect of T-cell depletion on the development of bleomycin-induced pulmonary fibrosis in the rat (abstr) Am Rev Respir Dis. 1980;121(suppl):99.
15. Schrier DJ, Phan SH, McGarry BM. The effects of the nude (nu/nu) mutation on bleomycin-induced pulmonary fibrosis: a biochemical evaluation. Am Rev Respir Dis. 1983;127:614-617.
16. Schrier DJ, Phan SH. Modulation of bleomycin-induced pulmonary fibrosis in the BALB/c mouse by cyclophosphamicle-sensitive T cells. Am J Pathol. 1984;116:270-278.
17. Szapiel SV, Elson NA, Fulmer JD, Hunnighake GW, Crystal RG. Bleomycin-induced interstitial pulmonary disease in the nude athymic mouse. Am Rev Respir Dis. 1979;120:893-899.
18. Janick-Buckner D, Ranges GE, Hacker MP. Effects of cytotoxic monoclonal antibody depletion of T lymphocyte subpopulations on bleomycin-induced lung damage in C57BL/6J mice. Toxicol Appl Pharmacol. 1989;100:474-484.
19. Sendelbach LE, Lindenschmidt RC, Witschi HP. The effect of cyclosporin A on pulmonary fibrosis induced by butylated hydroxytoluene, bleomycin and beryllium sulfate. Toxicol Lett. 1985;26:169-173.
20. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the Falin phenol reagent. J Biol Chem. 1951;193:265-275.
21. Snedecor GW, Cochran WG. Statistical Methods, 6th ed. Ames, IA: Iowa State University Press; 1967:258-298.
22. Brownlee KA. Statistical theory and methodology, 2d ed. New York: Wiley; 1967:300-301.
23. Piguet PF. Cytokines involved in pulmonary fibrosis. Int Rev Exp Pathol. 1993;34b:173-181.
24. Schrier DJ, Phan SH, Ward PA. Cellular sensitivity to collagen in bleomycin treated rats. J Immunol. 1982;129:2156-2159.
25. Calderon E, Lockey RF, Bukantz SC, Coffey RG, Letford DK. Is there a role for cyclosporin in asthma? J Allergy Clin Immunol. 1992;89:629-636.
26. Struhar D, Greif J, Harbeck RJ. Cass II antigens of the major histocompatibility complex are increased in lungs of bleomycin-treated rats. Immunol Lett. 1990;26:197-202.
27. Halloran PF, Urmson J, Farkas S et al. Effects of cyclosporine on systemic MHC expression: evidence that non T cells produce interferon gamma in vivo and are inhibited by cyclosporine. Transplantation. 1988;46:68S-72S.
28. Nguen DT, Eskanclari MK, DeForge LE, et al. Cyclosporin A modulation of tumor necrosis factor gene expression and effects in vitro and in vivo. J Immunol. 1990;144:3822-3828.
29. Piguet PF, Collart MA, Grau GE, Kapanci Y, Vassali P. Tumor necrosis factor/cachectin plays a key role in bleomycin-induced pneumopathy and fibrosis. J Exp Med. 1989;170:655-663.
30. Piguet PF, Vesin C. Treatment by human recombinant soluble TNF receptor of pulmonary fibrosis induced by bleomycin or silica in mice. Eur Respir J. 1994;7:515-518.
31. Thomson AW, Milton JI, Aldridge RD. Inhibition of drug induced eosinophilia by cyclosporin A. Scand J Immunol. 1986;24:163-170.
32. Wang JM, Denis M, Fournier M, Laviolette M. Cyclosporin A increases the pulmonary eosinophilia induced by inhaled Aspergillus antigen in mice. Clin Exp Immunol. 1993;93:323-330.
33. Kay AB. Origin of type 2 helper T cells. N Engl J Med. 1994;330:567-569.
34. Kroegel C, Virchow JC Jr, Luttmann W, Walker C, Warner JA. Pulmonary immune cells in health and disease: the eosinophil leukocyte (Part 1). Eur Respir J. 1994;7:519-543.