Synthesis and CNS activity of new 1-alkyl-2-aryl-7-hydroxy-5(1H)oxo-imidazo[1,2-a]pyrymidines

Acta Poloniae Pharmaceutica - Drug Research

Volumn 53, Issue 3, 1996, Pages 209-212

  Matosiuk, Dariusz ^a   Tkaczyński, Tadeusz ^a   Stefańczyk, Janusz ^a  

^a MEDICAL UNIVERSITY OF LUBLIN   (Poland)

Author keywords

1 alkyl 2 aryl 7 hydroxy 5(1H)oxo 2,3 dihydroimidazo 1,2 a pyrimidines; CNS activity; Synthesis

Indexed keywords

BARBITURIC ACID DERIVATIVE; HYDROXYL GROUP; IMIDAZOLE DERIVATIVE; IMIDAZOLINE DERIVATIVE; MALONIC ACID DERIVATIVE; POLYCYCLIC AROMATIC HYDROCARBON DERIVATIVE; PYRIMIDINE DERIVATIVE;

ANIMAL EXPERIMENT; ARTICLE; CENTRAL NERVOUS SYSTEM; DRUG ACTIVITY; DRUG SCREENING; DRUG SYNTHESIS; INTRAPERITONEAL DRUG ADMINISTRATION; LD 50; MALE; MOUSE; NONHUMAN; PHYSICAL CHEMISTRY; RAT; SEDATION;

ANIMALS; APOMORPHINE; CATALEPSY; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; HALOPERIDOL; HYPOTHERMIA; LETHAL DOSE 50; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MALONATES; MICE; MOTOR ACTIVITY; PAIN; PYRIMIDINES; RATS; RATS, WISTAR; RESERPINE; SEIZURES; SLEEP; STEREOTYPED BEHAVIOR; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0030005344     PISSN: 00016837     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (5)

1. Staechle H.; Koeppe H., Kummer W., Danneberg P.: DE 2 109 524.
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5. Matosiuk D., Tkaczyński T., Jagiełło-Wójtowicz E., Kleinrok Z., Chodkowska A.: Annales UMSC, Sectio DDD VI/VII (15), 115, (1993/1994).