메뉴 건너뛰기




Volumn 272, Issue 5261, 1996, Pages 554-557

Ocular dominance plasticity under metabotropic glutamate receptor blockade

Author keywords

[No Author keywords available]

Indexed keywords

GLUTAMATE RECEPTOR; GLUTAMATE RECEPTOR ANTAGONIST; METABOTROPIC RECEPTOR; PHOSPHATIDYLINOSITIDE;

EID: 0030005117     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.272.5261.554     Document Type: Article
Times cited : (56)

References (69)
  • 1
    • 78651126861 scopus 로고
    • T. N. Wiesel and D. H. Hubel, J. Neurophysiol 26, 1003 (1963); C. J Shatz and M. P. Stryker, J. Physiol. 281, 267 (1978); C. J. Shatz, Neuron 5, 745 (1990).
    • (1963) J. Neurophysiol , vol.26 , pp. 1003
    • Wiesel, T.N.1    Hubel, D.H.2
  • 2
    • 0018198770 scopus 로고
    • T. N. Wiesel and D. H. Hubel, J. Neurophysiol 26, 1003 (1963); C. J Shatz and M. P. Stryker, J. Physiol. 281, 267 (1978); C. J. Shatz, Neuron 5, 745 (1990).
    • (1978) J. Physiol. , vol.281 , pp. 267
    • Shatz, C.J.1    Stryker, M.P.2
  • 3
    • 0025644363 scopus 로고
    • T. N. Wiesel and D. H. Hubel, J. Neurophysiol 26, 1003 (1963); C. J Shatz and M. P. Stryker, J. Physiol. 281, 267 (1978); C. J. Shatz, Neuron 5, 745 (1990).
    • (1990) Neuron , vol.5 , pp. 745
    • Shatz, C.J.1
  • 4
    • 0027997686 scopus 로고
    • F. Conquet et al., Nature 372, 237 (1994); A. Aiba et al., Cell 79, 365 (1994).
    • (1994) Nature , vol.372 , pp. 237
    • Conquet, F.1
  • 5
    • 0028139045 scopus 로고
    • F. Conquet et al., Nature 372, 237 (1994); A. Aiba et al., Cell 79, 365 (1994).
    • (1994) Cell , vol.79 , pp. 365
    • Aiba, A.1
  • 6
    • 0028858986 scopus 로고
    • G Riedel, G Casabona, K. G. Reymann, J. Neurosci. 15, 87 (1995); G. Richter-Levin, M. L. Errington, H. Maegawa, T. V P Bliss, Neuropharmacology 33, 853 (1994); G. Riedel, W. Wetzel, K G. Reymann, Neurosci. Lett 167, 141 (1994).
    • (1995) J. Neurosci. , vol.15 , pp. 87
    • Riedel, G.1    Casabona, G.2    Reymann, K.G.3
  • 8
    • 0028181168 scopus 로고
    • G Riedel, G Casabona, K. G. Reymann, J. Neurosci. 15, 87 (1995); G. Richter-Levin, M. L. Errington, H. Maegawa, T. V P Bliss, Neuropharmacology 33, 853 (1994); G. Riedel, W. Wetzel, K G. Reymann, Neurosci. Lett 167, 141 (1994).
    • (1994) Neurosci. Lett , vol.167 , pp. 141
    • Riedel, G.1    Wetzel, W.2    Reymann, K.G.3
  • 9
    • 0027208145 scopus 로고
    • Z. I. Bashir et al., Nature 363, 347 (1993).
    • (1993) Nature , vol.363 , pp. 347
    • Bashir, Z.I.1
  • 10
    • 0027195617 scopus 로고
    • S. M. Dudek and M. F. Bear, J. Neurosci. 13, 2910 (1993), S. M. Dudek, F. W Hester, M J Friedlander, Soc Neurosci Abstr 20, 605 8 (1994).
    • (1993) J. Neurosci. , vol.13 , pp. 2910
    • Dudek, S.M.1    Bear, M.F.2
  • 12
    • 0028244082 scopus 로고
    • V Y. Bolshakov and S. A Siegelbaum, Science 264, 1148 (1994); Z. I. Bashir et al., Eur. J. Pharmacol. 239, 265 (1993); X-D Yang, J. A. Connor, D S. Faber, J. Neurophysiol. 71, 1586 (1994); P.-L. YI et al , Neurosci. Lett 185, 207 (1995); Z. I. Bashir and G. L. Collingridge, Exp. Brain Res. 100, 437 (1994); S M O'Mara, M. J. Rowan, R. Anwyl, Neuropharmacology 34, 983 (1995) [but see D K. Selig et al., J. Neurophysiol. 74, 1075 (1995)]
    • (1994) Science , vol.264 , pp. 1148
    • Bolshakov, V.Y.1    Siegelbaum, S.A.2
  • 13
    • 0027166147 scopus 로고
    • V Y. Bolshakov and S. A Siegelbaum, Science 264, 1148 (1994); Z. I. Bashir et al., Eur. J. Pharmacol. 239, 265 (1993); X-D Yang, J. A. Connor, D S. Faber, J. Neurophysiol. 71, 1586 (1994); P.-L. YI et al , Neurosci. Lett 185, 207 (1995); Z. I. Bashir and G. L. Collingridge, Exp. Brain Res. 100, 437 (1994); S M O'Mara, M. J. Rowan, R. Anwyl, Neuropharmacology 34, 983 (1995) [but see D K. Selig et al., J. Neurophysiol. 74, 1075 (1995)]
    • (1993) Eur. J. Pharmacol. , vol.239 , pp. 265
    • Bashir, Z.I.1
  • 14
    • 0028289230 scopus 로고
    • V Y. Bolshakov and S. A Siegelbaum, Science 264, 1148 (1994); Z. I. Bashir et al., Eur. J. Pharmacol. 239, 265 (1993); X-D Yang, J. A. Connor, D S. Faber, J. Neurophysiol. 71, 1586 (1994); P.-L. YI et al , Neurosci. Lett 185, 207 (1995); Z. I. Bashir and G. L. Collingridge, Exp. Brain Res. 100, 437 (1994); S M O'Mara, M. J. Rowan, R. Anwyl, Neuropharmacology 34, 983 (1995) [but see D K. Selig et al., J. Neurophysiol. 74, 1075 (1995)]
    • (1994) J. Neurophysiol. , vol.71 , pp. 1586
    • Yang, X.-D.1    Connor, J.A.2    Faber, D.S.3
  • 15
    • 0028878157 scopus 로고
    • V Y. Bolshakov and S. A Siegelbaum, Science 264, 1148 (1994); Z. I. Bashir et al., Eur. J. Pharmacol. 239, 265 (1993); X-D Yang, J. A. Connor, D S. Faber, J. Neurophysiol. 71, 1586 (1994); P.-L. YI et al , Neurosci. Lett 185, 207 (1995); Z. I. Bashir and G. L. Collingridge, Exp. Brain Res. 100, 437 (1994); S M O'Mara, M. J. Rowan, R. Anwyl, Neuropharmacology 34, 983 (1995) [but see D K. Selig et al., J. Neurophysiol. 74, 1075 (1995)]
    • (1995) Neurosci. Lett , vol.185 , pp. 207
    • Yi, P.-L.1
  • 16
    • 0027991749 scopus 로고
    • V Y. Bolshakov and S. A Siegelbaum, Science 264, 1148 (1994); Z. I. Bashir et al., Eur. J. Pharmacol. 239, 265 (1993); X-D Yang, J. A. Connor, D S. Faber, J. Neurophysiol. 71, 1586 (1994); P.-L. YI et al , Neurosci. Lett 185, 207 (1995); Z. I. Bashir and G. L. Collingridge, Exp. Brain Res. 100, 437 (1994); S M O'Mara, M. J. Rowan, R. Anwyl, Neuropharmacology 34, 983 (1995) [but see D K. Selig et al., J. Neurophysiol. 74, 1075 (1995)]
    • (1994) Exp. Brain Res. , vol.100 , pp. 437
    • Bashir, Z.I.1    Collingridge, G.L.2
  • 17
    • 0029099597 scopus 로고
    • V Y. Bolshakov and S. A Siegelbaum, Science 264, 1148 (1994); Z. I. Bashir et al., Eur. J. Pharmacol. 239, 265 (1993); X-D Yang, J. A. Connor, D S. Faber, J. Neurophysiol. 71, 1586 (1994); P.-L. YI et al , Neurosci. Lett 185, 207 (1995); Z. I. Bashir and G. L. Collingridge, Exp. Brain Res. 100, 437 (1994); S M O'Mara, M. J. Rowan, R. Anwyl, Neuropharmacology 34, 983 (1995) [but see D K. Selig et al., J. Neurophysiol. 74, 1075 (1995)]
    • (1995) Neuropharmacology , vol.34 , pp. 983
    • O'Mara, S.M.1    Rowan, M.J.2    Anwyl, R.3
  • 18
    • 0029121981 scopus 로고
    • V Y. Bolshakov and S. A Siegelbaum, Science 264, 1148 (1994); Z. I. Bashir et al., Eur. J. Pharmacol. 239, 265 (1993); X-D Yang, J. A. Connor, D S. Faber, J. Neurophysiol. 71, 1586 (1994); P.-L. YI et al , Neurosci. Lett 185, 207 (1995); Z. I. Bashir and G. L. Collingridge, Exp. Brain Res. 100, 437 (1994); S M O'Mara, M. J. Rowan, R. Anwyl, Neuropharmacology 34, 983 (1995) [but see D K. Selig et al., J. Neurophysiol. 74, 1075 (1995)]
    • (1995) J. Neurophysiol. , vol.74 , pp. 1075
    • Selig, D.K.1
  • 20
    • 0027939620 scopus 로고
    • N. Kato, Proc. Natl Acad Sci. U.S A 90, 3650 (1993); H Haruta et al., Neuroreport 5, 1829 (1994).
    • (1994) Neuroreport , vol.5 , pp. 1829
    • Haruta, H.1
  • 21
    • 0028350558 scopus 로고
    • N. A. Hartell, Neuroreport 5, 913 (1994); R Shigemoto et al., Neuron 12, 1245 (1994); A. Aiba et al , Cell 79, 377 (1994), age dependence of cerebellar LTD has not yet been established.
    • (1994) Neuroreport , vol.5 , pp. 913
    • Hartell, N.A.1
  • 22
    • 0028284466 scopus 로고
    • N. A. Hartell, Neuroreport 5, 913 (1994); R Shigemoto et al., Neuron 12, 1245 (1994); A. Aiba et al , Cell 79, 377 (1994), age dependence of cerebellar LTD has not yet been established.
    • (1994) Neuron , vol.12 , pp. 1245
    • Shigemoto, R.1
  • 23
    • 0028149789 scopus 로고
    • N. A. Hartell, Neuroreport 5, 913 (1994); R Shigemoto et al., Neuron 12, 1245 (1994); A. Aiba et al , Cell 79, 377 (1994), age dependence of cerebellar LTD has not yet been established.
    • (1994) Cell , vol.79 , pp. 377
    • Aiba, A.1
  • 24
    • 0029027248 scopus 로고
    • S. N. M Reid, C. Romano, T. Hughes, N W. Daw, J. Comp. Neurol 355, 470 (1995), S. N. M. Reid, C Romano, T. Hughes, D. Devlin, N W. Daw, Soc Neurosci. Abstr. 21, 795 7 (1995); M. V. Catania et al., Neuroscience 61, 481 (1994).
    • (1995) J. Comp. Neurol , vol.355 , pp. 470
    • Reid, S.N.M.1    Romano, C.2    Hughes, T.3    Daw, N.W.4
  • 26
    • 0028147196 scopus 로고
    • S. N. M Reid, C. Romano, T. Hughes, N W. Daw, J. Comp. Neurol 355, 470 (1995), S. N. M. Reid, C Romano, T. Hughes, D. Devlin, N W. Daw, Soc Neurosci. Abstr. 21, 795 7 (1995); M. V. Catania et al., Neuroscience 61, 481 (1994).
    • (1994) Neuroscience , vol.61 , pp. 481
    • Catania, M.V.1
  • 27
    • 0024437798 scopus 로고
    • S M Dudek and M F. Bear, Science 246, 673 (1989); W W.-G. Jia, Y. Lin, M Cynader, Dev. Brain Res. 85, 109 (1995).
    • (1989) Science , vol.246 , pp. 673
    • Dudek, S.M.1    Bear, M.F.2
  • 30
    • 0027240404 scopus 로고
    • S. LeVay, M P. Stryker, C. J. Shatz, J. Comp Neurol. 179, 223 (1978), A. Antonini and M P. Stryker, J. Neurosci. 13, 3549 (1993).
    • (1993) J. Neurosci. , vol.13 , pp. 3549
    • Antonini, A.1    Stryker, M.P.2
  • 32
    • 0028271580 scopus 로고
    • A. Kirkwood, S. M. Dudek, J. T. Gold, C. D. Aizenman, M F Bear, Science 260, 1518 (1993); A. Kirkwood and M. F. Bear, J. Neurosci. 14, 3404 (1994); A. Kirkwood, H.-K. Lee, M. F. Bear, Nature 375, 328 (1995).
    • (1994) J. Neurosci. , vol.14 , pp. 3404
    • Kirkwood, A.1    Bear, M.F.2
  • 33
    • 0029048970 scopus 로고
    • A. Kirkwood, S. M. Dudek, J. T. Gold, C. D. Aizenman, M F Bear, Science 260, 1518 (1993); A. Kirkwood and M. F. Bear, J. Neurosci. 14, 3404 (1994); A. Kirkwood, H.-K. Lee, M. F. Bear, Nature 375, 328 (1995).
    • (1995) Nature , vol.375 , pp. 328
    • Kirkwood, A.1    Lee, H.-K.2    Bear, M.F.3
  • 34
    • 0017893556 scopus 로고    scopus 로고
    • U Drager, J. Neurophysiol. 41, 28 (1978); M Fagiolini et al., Vision Res. 34, 709 (1994). J. A. Gordon and M. P Stryker [J. Neurosci, in press] show that ocular dominance plasticity in mouse primary visual cortex is subject to the same conditions and occurs in the same way as in the cat, involving both intracortical and thalamocortical changes (1).
    • (1978) J. Neurophysiol. , vol.41 , pp. 28
    • Drager, U.1
  • 35
    • 0028011961 scopus 로고
    • U Drager, J. Neurophysiol. 41, 28 (1978); M Fagiolini et al., Vision Res. 34, 709 (1994). J. A. Gordon and M. P Stryker [J. Neurosci, in press] show that ocular dominance plasticity in mouse primary visual cortex is subject to the same conditions and occurs in the same way as in the cat, involving both intracortical and thalamocortical changes (1).
    • (1994) Vision Res. , vol.34 , pp. 709
    • Fagiolini, M.1
  • 36
    • 0017893556 scopus 로고    scopus 로고
    • in press
    • U Drager, J. Neurophysiol. 41, 28 (1978); M Fagiolini et al., Vision Res. 34, 709 (1994). J. A. Gordon and M. P Stryker [J. Neurosci, in press] show that ocular dominance plasticity in mouse primary visual cortex is subject to the same conditions and occurs in the same way as in the cat, involving both intracortical and thalamocortical changes (1).
    • J. Neurosci
    • Gordon, J.A.1    Stryker, M.P.2
  • 37
    • 15844379239 scopus 로고    scopus 로고
    • note
    • 2, and 11 glucose. Extracellular pipettes (1 M NaCl, 1-3 megohm) monitored stable, half-maximal baseline field potentials evoked from layer IV by a bipolar Pt-lr electrode delivering 100-μs pulses at 0.1 Hz. Five episodes of TBS were given at 10-s intervals to induce LTP before depotentiation was attempted with 900 pulses at 1 Hz A single TBS consisted of 10 repetitions of four stimuli at 100 Hz delivered at 200-ms intervals (12). All experiments were terminated by bath application of 10 μM 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX, Tocns, UK) and 50 μM D-(-)-2-amino-5-phosphonovaleric acid (D-APV, Sigma) to determine the synaptic component of the field response. Similar results were obtained by measurements of synaptic slope or peak amplitude normalized to the baseline period before TBS, and renormalized to the 10 min preceding 1-Hz stimulation to adjust for variable elapsed time post-TBS across experiments. Both LTP and depotentiation were prevented by the N-methyl-D-aspartate receptor antagonist APV, as also reported for LTD of naïve synapses (12). R,S-α-MCPG or (+)-MCPG (Tocris) were dissolved in 100 mM NaOH at 50 mM, then diluted to 500 μM in ACSF.
  • 38
    • 0025163880 scopus 로고
    • K R. Stratton, P. F. Worley, J. M. Baraban, Eur. J. Pharmacol. 186, 357 (1990); S. Charpak, B. H. Gähwiler, K. Q. Do, T. Knopfel, Nature 347, 765 (1990); R W. Gereau and P. J. Conn, J. Neurophysiol. 74, 122 (1995); A Baskys. Trends Neurosci. 15, 92 (1992).
    • (1990) Eur. J. Pharmacol. , vol.186 , pp. 357
    • Stratton, K.R.1    Worley, P.F.2    Baraban, J.M.3
  • 39
    • 0025095856 scopus 로고
    • K R. Stratton, P. F. Worley, J. M. Baraban, Eur. J. Pharmacol. 186, 357 (1990); S. Charpak, B. H. Gähwiler, K. Q. Do, T. Knopfel, Nature 347, 765 (1990); R W. Gereau and P. J. Conn, J. Neurophysiol. 74, 122 (1995); A Baskys. Trends Neurosci. 15, 92 (1992).
    • (1990) Nature , vol.347 , pp. 765
    • Charpak, S.1    Gähwiler, B.H.2    Do, K.Q.3    Knopfel, T.4
  • 40
    • 0029145935 scopus 로고
    • K R. Stratton, P. F. Worley, J. M. Baraban, Eur. J. Pharmacol. 186, 357 (1990); S. Charpak, B. H. Gähwiler, K. Q. Do, T. Knopfel, Nature 347, 765 (1990); R W. Gereau and P. J. Conn, J. Neurophysiol. 74, 122 (1995); A Baskys. Trends Neurosci. 15, 92 (1992).
    • (1995) J. Neurophysiol. , vol.74 , pp. 122
    • Gereau, R.W.1    Conn, P.J.2
  • 41
    • 0026598755 scopus 로고
    • K R. Stratton, P. F. Worley, J. M. Baraban, Eur. J. Pharmacol. 186, 357 (1990); S. Charpak, B. H. Gähwiler, K. Q. Do, T. Knopfel, Nature 347, 765 (1990); R W. Gereau and P. J. Conn, J. Neurophysiol. 74, 122 (1995); A Baskys. Trends Neurosci. 15, 92 (1992).
    • (1992) Trends Neurosci. , vol.15 , pp. 92
    • Baskys, A.1
  • 42
    • 0022249586 scopus 로고
    • 3-guanosine 5′-triphosphate (3 to 8 megohm, pH 7 2, 290 to 300 mOsm), t-ACPD (Tocris) was dissolved in ACSF and bath applied.
    • (1985) J. Neurophysiol. , vol.54 , pp. 782
    • McCormick, D.A.1
  • 44
    • 15844405536 scopus 로고    scopus 로고
    • note
    • In each hemisphere, multibarreled iontophoretic pipettes were lowered into striate cortex just beyond the most distant penetration site used for determination of ocular dominance (<2 mm from cannula). Activation thresholds for kainic acid and t-ACPD (both 20 mM in saline) were determined by gradually increasing iontophoretic ejection currents (WPI model 160) in 20-nA steps once every 60 s. Each round of iontophoresis was preceded by isolation of multiple units with visual stimulation and concluded by verifying the presence of the same visually driven cells. Additional iontophoretic penetrations amidst the single-unit sites and well beyond (>3 mm) confirmed that all shifted cells lay within a region in which mGluRs were blocked.
  • 46
    • 0027977832 scopus 로고
    • K. Lingenhöhl, H.-R. Olpe, N. Bendali, T. Knöpfel, Neurosci. Res. 18, 229 (1993); P. M. B. Cahusac, Eur. J. Neurosci. 6, 1505 (1994); D E. Jane et al., Neuropharmacology 32, 725 (1993).
    • (1994) Eur. J. Neurosci. , vol.6 , pp. 1505
    • Cahusac, P.M.B.1
  • 47
    • 0027174866 scopus 로고
    • K. Lingenhöhl, H.-R. Olpe, N. Bendali, T. Knöpfel, Neurosci. Res. 18, 229 (1993); P. M. B. Cahusac, Eur. J. Neurosci. 6, 1505 (1994); D E. Jane et al., Neuropharmacology 32, 725 (1993).
    • (1993) Neuropharmacology , vol.32 , pp. 725
    • Jane, D.E.1
  • 50
    • 0016440334 scopus 로고
    • C R. Olson and R. D. Freeman, J. Neurophysiol. 38, 26 (1975); C. Blakemore, M J. Hawken, R F. Mark, J. Physiol. (London) 327, 489 (1982), L Mioche and W. Singer, J. Neurophysiol. 62, 185 (1989); T K. Hensch et al , Soc. Neurosci Abstr. 21, 795.4 (1995).
    • (1975) J. Neurophysiol. , vol.38 , pp. 26
    • Olson, C.R.1    Freeman, R.D.2
  • 51
    • 0020002235 scopus 로고
    • C R. Olson and R. D. Freeman, J. Neurophysiol. 38, 26 (1975); C. Blakemore, M J. Hawken, R F. Mark, J. Physiol. (London) 327, 489 (1982), L Mioche and W. Singer, J. Neurophysiol. 62, 185 (1989); T K. Hensch et al , Soc. Neurosci Abstr. 21, 795.4 (1995).
    • (1982) J. Physiol. (London) , vol.327 , pp. 489
    • Blakemore, C.1    Hawken, M.J.2    Mark, R.F.3
  • 52
    • 0024382828 scopus 로고
    • C R. Olson and R. D. Freeman, J. Neurophysiol. 38, 26 (1975); C. Blakemore, M J. Hawken, R F. Mark, J. Physiol. (London) 327, 489 (1982), L Mioche and W. Singer, J. Neurophysiol. 62, 185 (1989); T K. Hensch et al , Soc. Neurosci Abstr. 21, 795.4 (1995).
    • (1989) J. Neurophysiol. , vol.62 , pp. 185
    • Mioche, L.1    Singer, W.2
  • 53
    • 0016440334 scopus 로고
    • C R. Olson and R. D. Freeman, J. Neurophysiol. 38, 26 (1975); C. Blakemore, M J. Hawken, R F. Mark, J. Physiol. (London) 327, 489 (1982), L Mioche and W. Singer, J. Neurophysiol. 62, 185 (1989); T K. Hensch et al , Soc. Neurosci Abstr. 21, 795.4 (1995).
    • (1995) Soc. Neurosci Abstr. , vol.21
    • Hensch, T.K.1
  • 55
    • 0028912822 scopus 로고
    • S. Nakanishi and M Masu, Annu. Rev. Biophys. Biomol. Struct. 23, 319 (1994), J.-P. Pin and R Duvoisin, Neuropharmacology 34, 1 (1995)
    • (1995) Neuropharmacology , vol.34 , pp. 1
    • Pin, J.-P.1    Duvoisin, R.2
  • 56
    • 0028350739 scopus 로고
    • Y. Hayashi et al., J. Neurosci. 14, 3370 (1994); C. Thomsen, E. Boel, P. D. Suzdak, Eur. J. Pharmacol. 267, 77 (1994).
    • (1994) J. Neurosci. , vol.14 , pp. 3370
    • Hayashi, Y.1
  • 58
    • 0027509779 scopus 로고
    • E F Birse et al., Neuroscience 52, 481 (1993); S. A. Eaton et al., Eur. J. Pharmacol. 244, 195 (1993)
    • (1993) Neuroscience , vol.52 , pp. 481
    • Birse, E.F.1
  • 59
    • 0027448332 scopus 로고
    • E F Birse et al., Neuroscience 52, 481 (1993); S. A. Eaton et al., Eur. J. Pharmacol. 244, 195 (1993)
    • (1993) Eur. J. Pharmacol. , vol.244 , pp. 195
    • Eaton, S.A.1
  • 61
    • 0029043591 scopus 로고
    • Although C. Joly et al. [J. Neurosci. 15, 3970 (1995)] suggest, contrary to (26), that racemic R,S-MCPG is not an effective antagonist at mGluR5 splice variants compared with mGluR1, the same laboratory has shown the stereoselective isomer (+)-MCPG to block all known group I mGluRs [I. Brabet et al., Neuropharmacology 34, 895 (1995)], consistent with (26).
    • (1995) J. Neurosci. , vol.15 , pp. 3970
    • Joly, C.1
  • 62
    • 0029133818 scopus 로고
    • Although C. Joly et al. [J. Neurosci. 15, 3970 (1995)] suggest, contrary to (26), that racemic R,S-MCPG is not an effective antagonist at mGluR5 splice variants compared with mGluR1, the same laboratory has shown the stereoselective isomer (+)-MCPG to block all known group I mGluRs [I. Brabet et al., Neuropharmacology 34, 895 (1995)], consistent with (26).
    • (1995) Neuropharmacology , vol.34 , pp. 895
    • Brabet, I.1
  • 63
    • 0028245013 scopus 로고
    • D. E. Jane et al., Br. J. Pharmacol. 112, 809 (1994); O. J. Manzoni, P E. Castillo, R. A. Nicoll, Neuropharmacology 34, 965 (1995). Only presynaptic mGluR4 is not blocked by MCPG in vitro (24).
    • (1994) Br. J. Pharmacol. , vol.112 , pp. 809
    • Jane, D.E.1
  • 64
    • 0029134540 scopus 로고
    • D. E. Jane et al., Br. J. Pharmacol. 112, 809 (1994); O. J. Manzoni, P E. Castillo, R. A. Nicoll, Neuropharmacology 34, 965 (1995). Only presynaptic mGluR4 is not blocked by MCPG in vitro (24).
    • (1995) Neuropharmacology , vol.34 , pp. 965
    • Manzoni, O.J.1    Castillo, P.E.2    Nicoll, R.A.3
  • 65
    • 0028337693 scopus 로고
    • O. Manzoni, M. G. Weisskopf, R A Nicoll, Eur. J. Neurosci. 6, 1050 (1994); P Chinestra, L Anikstejn, D. Diabira, Y Ben-An, J. Neurophysiol. 70, 2684 (1993); A. Y. Hsia et al., Neuropharmacology 34, 1567 (1995).
    • (1994) Eur. J. Neurosci. , vol.6 , pp. 1050
    • Manzoni, O.1    Weisskopf, M.G.2    Nicoll, R.A.3
  • 66
  • 67
    • 0028829134 scopus 로고
    • O. Manzoni, M. G. Weisskopf, R A Nicoll, Eur. J. Neurosci. 6, 1050 (1994); P Chinestra, L Anikstejn, D. Diabira, Y Ben-An, J. Neurophysiol. 70, 2684 (1993); A. Y. Hsia et al., Neuropharmacology 34, 1567 (1995).
    • (1995) Neuropharmacology , vol.34 , pp. 1567
    • Hsia, A.Y.1
  • 69
    • 15844373811 scopus 로고    scopus 로고
    • note
    • We thank S. Harns for assistance during the implant surgeries, and M. Fagiolini and R. A. Nicoll for critical comments on the manuscript. T.K.H. is a Howard Hughes Medical Institute Predoctoral Fellow Supported by grants to M.P.S from the National Institutes of Health (EY02874) and the Human Frontiers Science Program (RG69/93).


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.