Effect of diazepam on plasma γ-aminobutyric acid in sons of alcoholic fathers

Alcoholism: Clinical and Experimental Research

Volumn 20, Issue 2, 1996, Pages 343-347

  Cowley, Deborah S ^a,d   Roy Byrne, Peter P ^a   Greenblatt, David J ^b   Kramer, Gerald L ^c   Petty, Frederick ^c  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^d UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Diazepam; GABA; Harm Avoidance; Novelty Seeking; Sons of Alcoholics

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; DIAZEPAM;

ACCIDENT PREVENTION; ADULT; ALCOHOLISM; ARTICLE; AVOIDANCE BEHAVIOR; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG RECEPTOR BINDING; FATHER CHILD RELATION; HUMAN; MALE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SEDATION;

ADOLESCENT; ADULT; ALCOHOLISM; AROUSAL; CHILD OF IMPAIRED PARENTS; DEFENSE MECHANISMS; DIAZEPAM; GABA MODULATORS; GAMMA-AMINOBUTYRIC ACID; GENOTYPE; HUMANS; MALE; PERSONALITY INVENTORY; RECEPTORS, GABA-A;

EID: 0030005116     PISSN: 01456008     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1530-0277.1996.tb01650.x     Document Type: Article

References (30)

1. Paul SM: GABA and glycine, in Bloom FE, Kupfer DJ (eds): Psychopharmacology: The Fourth Generation of Progress. New York, Raven Press Ltd., 1995, pp 87-94
2. Tallman J, Gallagher DW: The GABA-ergic system a locus of benzodiazepine action. Ann Rev Neurosci 8:21-44, 1985
3. Olsen RW: GABA-benzodiazepine-barbiturate receptor interactions. J Neurochem 37:1-13, 1981
4. Suzdak PD, Schwartz RD, Skolnick P, Paul S: Ethanol stimulates gamma-aminobutyric acid receptor-mediated chloride transport in rat brain synaptosomes. Proc Natl Acad Sci USA 83:4071-4075, 1986
5. Sellers E, Kalant H: Alcohol intoxication and withdrawal. N Engl J Med 294:757-762, 1976
6. Cooper BR, Viik K, Ferris RM, White HL: Antagonism of the enhanced susceptibility to audiogenic seizures during alcohol withdrawal in the rat by gamma-aminobutyric acid (GABA) and "GABA-mimetic" agents. J Pharmacol Exp Ther 209:396-403, 1979
7. Leitch GJ, Backes DJ, Siegman FS, Guthrie GD: Possible role of GABA in the development of tolerance to alcohol. Experientia 33:238-241, 1977
8. Buck KJ, Harris RA: Neuroadaptive responses to chronic ethanol. Alcohol Clin Exp Res 15:460-470, 1991
9. Gallaher E, Gionet S: Initial sensitivity and tolerance to ethanol in mice genetically selected for diazepam sensitivity. Alcohol Clin Exp Res 12:77-80, 1988
10. Petty F, Kramer GL, Hendrickse W: GABA and depression, in Mann JJ, Kupfer DJ (eds): Biology of Depressive Disorders. Part A. A Systems Perspective. New York, Plenum Press, 1993, pp 79-108
11. Zachmann M, Tocci P, Nyhan WL: The occurrence of gamma-aminobutyric acid in human tissues other than brain. J Biol Chem 241: 1355-1358, 1966
12. Loscher W, Frey HH: Transport of GABA at the blood-CSF interface. J Neurochem 38:1072-1079, 1982
13. Uhlhaas VS, Lanage H, Wappenschmidt J, Olek K: Free and conjugated CSF and plasma GABA in Huntington's chorea. Acta Neurol Scand 74:261-265, 1986
14. Bohlen P, Schechter PJ, van Damme W, Coquillat G, Dosch JC, Koch-Weser J: Automated assay of gamma-aminobutyric acid in human cerebrospinal fluid. Clin Chem 24:256-260, 1978
15. Ferkany JW, Butler IJ, Enna SJ: Effect of drugs on rat brain, cerebrospinal fluid, and blood GABA content. J Neurochem 33:29-33, 1979
16. Loscher W: GABA in plasma and cerebrospinal fluid of different species: Effects of gamma-acetylenic GABA, gamma-vinyl GABA, and sodium valproate. J Neurochem 32:1587-1591, 1979
17. Petty F, Fulton M, Moeller FG, Kramer G, Wilson L, Fraser K, Isbell P: Plasma gamma-aminobutyric acid (GABA) is low in alcoholics. Psychopharmacol Bull 29:277-281, 1993
18. Cotton N: The familial incidence of alcoholism: A review. J Stud Alcohol 40:89-116, 1979
19. Goodwin D, Schulsinger F, Moller N, et al: Drinking problems in adopted and nonadopted sons of alcoholics. Arch Gen Psychiatry 31:164-169, 1974
20. Cloninger CR, Bohman M, Sigvardsson S: Inheritance of alcohol abuse. Arch Gen Psychiatry 38:861-868, 1981
21. Pickens RW, Svikis DS, McGue M, Lykken DT, Heston LL, Clayton PJ: Heterogeneity in the inheritance of alcoholism: A study of male and female twins. Arch Gen Psychiatry 48:19-28, 1991
22. Moss HB, Yao JK, Burns M, Maddock J, Tarter RE: Plasma GABA-like activity in response to ethanol challenge in men at high risk for alcoholism. Biol Psychiatry 27:617-625, 1990
23. Garbutt JC, Miller LP, Kramer GL, Davis LL, Mason GA, Petty F: Serum GABA in young men at high or low risk for alcoholism. Alcohol Clin Exp 19:80A, 1995
24. Cowley DS, Roy-Byrne PP, Godon C, Greenblatt DJ, Ries R, Walker RD, Samson HH, Hommer DW: Response to diazepam in sons of alcoholics. Alcohol Clin Exp Res 16:1057-1063, 1992
25. Cowley DS, Roy-Byrne PP, Radant A, Hommer DW, Greenblatt DJ, Vitaliano PP, Godon C: Eye movement effects of diazepam in sons of alcoholic fathers and male control subjects. Alcohol Clin Exp Res 18:324-332, 1994
26. Roy-Byrne PP, Cowley DS, Hommer D, Greenblatt DJ, Kramer GL, Petty F: Effect of acute and chronic benzodiazepines on plasma GABA in anxious patients and controls. Psychopharmacology 109:153-156, 1992
27. Sobell L, Sobell M, Leo G, Cancilla A: Reliability of a time line method: Assessing normal drinkers' reports of recent drinking and a comparative evaluation across several populations. Br J Addict 83:393-402, 1988
28. Cahalan D, Cisin IH, Crossley HM: American Drinking Practices: A National Survey of Behavior and Attitudes Related to Alcoholic Beverages. Report No. 3. Washington, D.C., Social Research Group, The George Washington University, 1967
29. Selzer M: The Michigan Alcoholism Screening Test: The quest for a new diagnostic instrument. Am J Psychiatry 127:1653-1658, 1971
30. Cloninger CR, Sigvardsson S, Bohman M: Childhood personality predicts alcohol abuse in young adults. Alcohol Clin Exp Res 12:494-505, 1988