Blood lactate levels are better prognostic indicators than TNF and IL-6 levels in patients with septic shock

Intensive Care Medicine

Volumn 22, Issue 5, 1996, Pages 404-408

  Marecaux, G ^a   Pinsky, M R ^b   Dupont, E ^a   Kahn, R J ^a   Vincent, J L ^a  

^a ERASME HOSPITAL   (Belgium)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Blood lactate; Cytokine levels; Septic shock

Indexed keywords

CYTOKINE; INTERLEUKIN 6; LACTIC ACID; TUMOR NECROSIS FACTOR ALPHA;

ADULT; AGED; ARTICLE; BIOASSAY; BLOOD LEVEL; CLINICAL ARTICLE; CLINICAL TRIAL; ENZYME ASSAY; FEMALE; HUMAN; IMMUNORADIOMETRIC ASSAY; INTERMETHOD COMPARISON; LACTATE BLOOD LEVEL; MALE; PROGNOSIS; SEPTIC SHOCK;

ADULT; AGED; AGED, 80 AND OVER; FEMALE; HUMANS; INTERLEUKIN-6; LACTIC ACID; MALE; MIDDLE AGED; PROGNOSIS; PROSPECTIVE STUDIES; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SHOCK, SEPTIC; SURVIVAL ANALYSIS; TIME FACTORS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0030004690     PISSN: 03424642     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF01712155     Document Type: Article

References (39)

1. Rackow EC, Astiz ME, Bone RC (1991) Pathophysiology and treatment of septic shock. JAMA 266:548-554
2. Vincent JL (1991) Diagnostic and medical management/supportive care of patients with gram-negative bacteremia and septic shock. Infect Dis Clin North Am 5:807-816
3. Bone RC (1991) The pathogenesis of sepsis. Ann Intern Med 115:457-469
4. Knaus WA, Draper EA, Wagner DP, Zimmerman JE (1985) Prognosis in acute organ-system failure. Ann Surg 202:685-693
5. Tran DD, Groeneveld ABJ, Vander Meulen J, Nauta JJP, Strack Van Schijndel RJM, Thijs LG (1990) Age, chronic disease, sepsis, organ system failure, and mortality in a medical intensive care unit. Crit Care Med 18: 474-479
6. Vincent JL, Berlot G (1992) Cardiac effects of the mediators of sepsis. In: Lamy M, Thijs L (eds) Update on intensive care and emergency medicine. Springer, Berlin Heidelberg New York, pp 255-266
7. Beutler B, Milsark IW, Cerami A (1985) Passive immunization against cachectin/TNF protects mice from lethal effect of endotoxin. Science 229:869-871
8. Michie HR, Manogue KR, Spriggs DR, Revhaug A, O'Dwyer S, Dinarello CA, Cerani A, Wolff SM, Wilmore DW (1989) Detection of circulating tumor necrosis factor after endotoxin administration. N Engl J Med 318: 1481-1486
9. Van Deuren M, Van der Ven-Jongekrijk J, Demacker PN, Bartelink AK, Van Dalen R, Sauerwein RW, Gallati M, Vannice JL, Van der Meer JW (1994) Differential expression of proinflammatory cytokines and their inhibitors during the course of meningococcal infections. J Infect Dis 169:157-161
10. Keuter M, Dharmana E, Gasem MH, Van der Ven-Jongekrijk J, Demacker P, Sauerwein R, Gallati M, Van der Meer JW (1994) Patterns of proinflammatory cytokines and inhibitors during typhoid fever. J Infect Des 169: 1306-1311
11. Preiser JC, Schmartz D, Van der Linden P, Content J, Vandenbussche P, Buurman W, Sebald W, Dupont E, Pinsky MR, Vincent JL (1991) IL-6 administration has no acute hemodynamic effect in the dog. Cytokine 3:1-4
12. Waage A, Aasen AO (1992) Different role of cytokine mediators in spetic shock related to meningococcal disease and surgery. Immunology 127:221-230
13. Hack CE, De Groot ER, Felt-Bersma RJF, Nuijens JM, Strack Van Schijndel RJM, Eerenberg-Belner AJM, Thijs LG, Aarden LA (1989) Increased plasma levels of interleukin-6 in sepsis. Blood 74:1704-1710
14. Calandra T, Baumgartner JD, Grau DG, Wu MM, Lambert PM, Schellekens J, Verhoef J, Glauser MP (1990) Prognostic values of tumor necrosis factor/cachectin, interleukin-1, interferon-alpha, and interferon-gamma in the serum of patients with septic shock. J Infect Dis 161:982-987
15. Calandra T, Gerain J, Heumann D, Baumgartner JD, Glauser MP (1991) High circulating levels of interleukin-6 in patients with septic shock: evolution during sepsis, prognostic value, and interplay with other cytokines. Am J Med 91:23-29
16. Damas P, Reuter A, Gysen P, Demonty J, Lamy M, Franchimont P (1989) Tumor necrosis factor and interleukin-1 serum levels during severe sepsis in humans. Crit Care Med 17:975-979
17. Marks JD, Marks CB, Luce JM, Montgomery AB, Turner CB, Metz CA, Murray JF (1990) Plasma tumor necrosis factor in patients with septic shock. Am Rev Respir Dis 141:94-97
18. De Groote M, Martin MA, Densen P, Pfaller MA, Wenzel RP (1989) Plasma tumor necrosis levels in patients with presumed sepsis. JAMA 262:249-251
19. Debets JM, Kampmeijer R, Van der Linden MP, Buurman WA, Van der Linden CJ (1989) Plasma tumor necrosis factor and mortality in critically ill septic patients. Crit Care Med 17: 489-494
20. Pinsky MR, Vincent JL, Deviere J, Alegre M, Schandene L, Kahn RJ, Vandenbussche P, Content J, Dupont E (1993) Serum cytokine levels in human septic shock: relation to multiple-systems organ failure and mortality. Chest 103:565-575
21. Offner F, Philippe J, Vogelaers DP, Colardyn FC, Baele G, Baudrihaye M, Vermeulen A, Leroux-Roels G (1990) Serum tumor necrosis factor levels in patients with infectious disease and septic shock. J Lab Clin Med 116:100-105
22. Casay LC, Balk RA, Bone RC (1993) Plasma cytokine and endotoxin levels correlate with survival in patients with the sepsis syndrome [see comments]. Ann Intern Med 119:771-778
23. Vitek V, Cowley RA (1971) Blood lactate in the prognostic of various forms of shock. Ann Surg 173:308-313
24. Bakker J, Vincent JL (1991) The oxygen supply dependency phenomenon is associated with increased blood lactate levels. J Crit Care 6:152-159
25. Bakker J, Coffernils M, Leon M, Gris P, Vincent JL (1991) Blood lactate levels are superior to oxygen derived variables in predicting outcome in human septic shock. Chest 99:956-962
26. Vincent JL, Dufaye P, Berre J, Leeman M, Degaute JP, Kahn RJ (1983) Serial lactate determinations during circulatory shock. Crit Care Med 11:449-451
27. Mizock BA, Falk JL (1992) Lactic acidosis in critical illness. Crit Care Med 20:80-93
28. Waage A, Brandtzae GP, Halstensen A, Kierulf P, Espevik T (1989) The complex pattern of cytokines in serum from patients with meningococcal septic shock. J Exp Med 189:333-338
29. Damas P, Ledoux D, Nys M, Vrindts Y, DeGroote D, Franchimont P, Lamy M (1992) Cytokine serum levels during severe sepsis in human IL-6 as a marker of severity. Ann Surg 215:356-362
30. Ohzato H, Yoschizaki K, Nishimoto N, Ogata A, Tagoh H, Monden M, Gotoh M, Kihimoto T, Mori T (1992) Interleukin-6 as a new indicator of inflammatory status: detection of serum levels of interleukin-6 and C-reactive protein after surgery. Surgery 111: 201-209
31. Hall G, Desborough JP (1992) Interleukin-6 and the metabolic response to surgery. Br J Anaesth 69:337-338
32. Fassbender K, Pargger H, Muller W, Zimmerli W (1993) Interleukin-6 and acute-phase protein concentrations in surgical intensive care unit patients: diagnostic signs in nosocomial infection. Crit Care Med 21:1175-1180
33. Hoch R, Rodriguez R, Manning T, Bishop MJ, Mead P, Shoemaker WC, Abraham E (1993) Effects of accidental trauma on cytokine and endotoxin production. Crit Care Med 21:839-845
34. Rodriguez J, Miller C, Garner W, Till G, Gerrero P, Moore N, Corridore M, Normolle D, Smith D, Remick D (1993) Correlation of the local and systemic cytokine response with clinical outcome following thermal injury. J Trauma 34: 684-695
35. Parsons P, Moore A, Moore EE, Ikle D, Henson P, Worthen G (1992) Studies on the role of tumor necrosis factor in adult respiratory distress syndrome. Am Rev Respir Dis 146:694-700
36. Van Deventer SJ, Hart M, Van der Poll T, Hack E, Aarden LA (1993) Endotoxin and tumor necrosis factor alpha induced interleukin-8 release in humans. J Infect Dis 167:461-464
37. Van Zee KJ, DeForge L, Fischer E, Marano MA, Kenney JS, Remick DG, Lowry SF, Moldawer LL (1991) IL-8 in septic shock, endotoxinemia and after IL-1 administration. J Immunol 146: 3478-3482
38. Waring P, Wycherley K, Cary D, Nicola N, Metcalf D (1992) Leukemia inhibitory factor levels are elevated in septic shock and various inflammatory body fluids. J Clin Invest 90:2031-2037
39. Marchant A, Devière J, Byl B, De Groote D, Vincent JL (1994) Interleukin-10 production during septicaemia. Lancet 344:707-708