A microdosimetric-kinetic model of cell death from exposure to ionizing radiation of any LET, with experimental and clinical applications

International Journal of Radiation Biology

Volumn 69, Issue 6, 1996, Pages 739-755

  Hawkins, R B ^a  

^a OCHSNER MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CELL DEATH; CONTROLLED STUDY; IONIZING RADIATION; LINEAR ENERGY TRANSFER; MICRODOSIMETRY; MODEL; PRIORITY JOURNAL;

ANIMALS; CELL DEATH; CELL NUCLEUS; CELL SURVIVAL; CHO CELLS; CRICETINAE; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, RADIATION; KINETICS; LINEAR ENERGY TRANSFER; MATHEMATICS; MODELS, THEORETICAL;

EID: 0030004165     PISSN: 09553002     EISSN: None     Source Type: Journal    
DOI: 10.1080/095530096145481     Document Type: Article

References (27)

1. AGER, D. D., DEWEY, W. C., GARDINER, K., HARVEY, W., JOHNSON, R. T. and WALDREN, C. A., 1990, The measurement of radiation-induced DNA double-strand breaks by pulsed-field gel electrophoresis. Radiation Research, 122, 181-187.
2. BARENDSEN, G. W., 1994, The relationships between RBE and LET for different types of lethal damage in mammalian cells: biophysics and molecular mechanisms. Radiation Research, 139, 257-270.
3. BLÖCHER, D., 1988, DNA double-strand break repair determines the RBE of alpha-particles. International Journal of Radiation Biology, 54, 761-771.
4. BRENNER, D. J. and HALL, E. J., 1991, Conditions for the equivalence of continuous to pulsed low dose rate brachytherapy. International Journal of Radiation Oncology, Biology and Physics, 20, 181-190.
5. BRUCE, W. R., PEARSON, M. L. and FREEDHOFF, H. S., 1963, The linear energy transfer distribution resulting from primary and scattered x-rays and gamma rays with primary HVL's from 1.25 mm cm to 11 mm Pb. Radiation Research, 19, 606-620.
6. CURTIS, S. B., 1986, Lethal and potentially lethal lesions induced by irradiation - a unified repair model Radiation Research, 106, 252-270. [Erratum, Radiation Research, 119(1989), 584.]
7. CURTIS, S. B., 1991, Mechanistic models. In Physical and Chemical Mechanics in Molecular Radiation Biology, edited by W. A. Glass and M. N. Varnura (New York: Plenum), pp. 367-386.
8. DALE, R. G., 1985, The application of the linear-quadratic dose effect equation to fractionated and protracted radiotherapy. British Journal of Radiology, 58, 515-528.
9. ELKIND, K. M., SUTTON-GILBERT, H., MOSES, W. B., ALESCIO, T. and SWAIN, W., 1965, Radiation response of mammalian cells grown in culture. V. Temperature dependence of the repair of x-ray damage in surviving cells (aerobic and hypoxic). Radiation Research, 25, 359-376.
10. FRANKENBERG-SCHWAGER, M., 1989, Review of repair kinetics for ONA damage induced in eukaryotic cells in vitro by ionizing radiation. Radiotherapy and Oncology, 14, 307-320.
11. FRANKENBERG-SCHWAGER, M., FRANKENBERG, D., BLÖCHER, D. and ADAMCZYK, C., 1980, Repair of DNA double-strand breaks in irradiated yeast cells under nongrowth conditions. Radiation Research 82, 498-510.
12. HAWKINS, R. B., 1994, A statistical theory of cell killing by radiation of varying linear energy transfer quality. Radiation Research, 140, 366-374.
13. HAWKINS, R. B., 1996, A statistical theory of the dependence of RBE for cell death on LET. International Journal of Radiation Biology, (submitted).
14. HUTCHINSON, F., 1989, On the measurement of DNA double-strand breaks by neutral elution [see comments]. Radiation Research, 120, 182-186.
15. ICRU, 1970, Linear Energy Transfer, International Commission on Radiation Units and Measurements. Report no. 16 (ICRU: Washington).
16. KELLERER, A. M. and ROSSI, H. H., 1972, The theory of dual radiation action. Current Topics Radiation Research Quarterly, 8, 85-158.
17. KRASIN, F., and HUTCHINSON, F., 1977, Repair of DNA double-strand breaks in Escherichia coli, which requires recA function and the presence of a duplicate genome. Journal of Molecular Biology, 116, 81-98.
18. LEHMAN, A. R. and STEVENS, S., 1977, The production and repair of double strand breaks in cells from normal human and from patients with ataxia telangiectasia. Biochimica et Biophysica Acta, 474, 49-60.
19. LITTLE, J. B., 1969, Repair of sub-lethal and potentially lethal radiation damage in plateau phase cultures of human cells. Nature, 224, 804-806.
20. PHILLIPS, R. A. and TOLMACH, L. J., 1966, Repair of potentially lethal damage in x-irradiated HeLa cells. Radiation Research, 29, 413-432.
21. REVELL, G. H., 1974, The breakage-and reunion theory and the exchange theory for chromosomal aberrations induced by ionizing radiation. A short history. Advances in Radiation Biology, 4, 367-416.
22. STACKHOUSE, M. A. and BEDFORD, J. S., 1993a, An ionizing radiation-sensitive mutant of CHO cells: irs-20. I. Isolation and initial characterization. Radiation Research, 136, 241-249.
23. STACKHOUSE, M. A. and BEDFORD, J. S., 1993b, An ionizing radiation-sensitive mutant of CHO cells: irs-20. II. Dose-rate effects and cellular recovery processes. Radiation Research, 136, 250-254.
24. THAMES, H. D., 1985, An 'incomplete-repair' model for survival after fractionated and continuous irradiations. International Journal of Radiation Biology, 47, 319-339.
25. THAMES, H. D. and HENDRY, J. H., 1987, Fractionations in Radiotherapy (New York: Taylor & Francis), Appendices 7.2 and 7.3, pp. 246-249.
26. TOBIAS, C. A., BLAKELY, E. A., NGO, F. Q. H. and YANG, T. C. H., 1980, The repair-misrepair model of cell survival. In Radiation Biology in Cancer Research, edited by R. E. Meyn and H. R. Withers (New York: Raven), pp. 195-230.
27. ZACKRISSON, B., 1992, Radiobiological cell survival models. A methodological overview. Acta Oncologica, 31, 433-441.