Dosing and monitoring novoseven® treatment

Pathophysiology of Haemostasis and Thrombosis

Volumn 26, Issue , 1996, Pages 102-108

  Hedner, Ulla ^a  

^a NOVO NORDISK A S   (Denmark)

Author keywords

Extrinsic coagulation pathway; FVII; FVII tissue factor dependent coagulation; Hemophilia A B; Hemophilia with inhibitors

Indexed keywords

RECOMBINANT BLOOD CLOTTING FACTOR 7A;

CLINICAL TRIAL; CONFERENCE PAPER; HEMOPHILIA; HUMAN; NONHUMAN; PRIORITY JOURNAL;

CLINICAL TRIALS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; FACTOR VIIA; HEMOPHILIA A; HEMOSTASIS; HUMANS; MONITORING, PHYSIOLOGIC; RECOMBINANT PROTEINS;

EID: 0030003671     PISSN: 14248832     EISSN: 14248840     Source Type: Journal    
DOI: 10.1159/000217250     Document Type: Article

References (7)

1. Hedner U. Ljungberg J, Lund-Han-sen T: Comparison of the effect of plasma-derived and recombinant human FVIIa in vitro and in a rabbit model. Blood Coagul Fibrinolysis 1990;1:145-151.
2. Brinkhous KM. Hedner U. Garris JB, Diness V, Read M: Effect of recombinant factor Vila on the hemostatic defect in dogs with hemophilia A. hemophilia B, and von Willebrand disease. Proc Natl Acad Sci USA 1989;86:1382-1386.
3. Hedner U, Schulman S. Alberts KA. Blomback M, Johnsson H. Glazer S. Pingel K: Sucessful use of rFVIIa in a patient with severe hemoplutia A subjected to synovectomy. Lancet 1988;vol ii: 1193.
4. Glazcr S. Hedner U. Falch JF Clinical update on the use of recombinant factor Vila. Inhibitors to coagulation factors: in Aledort LM. Hover LW, Lusher JM, Rcisner HM, White GCII (eds): Proceedings of the Second International Symposium. New York. Plenum Publishing. in press.
5. Persson E, Ezban M. Nicolaisen EM, Erhardtscn E. Hedner U: Effects of acenocoumarol treatment on human plasma factor VII (abstract). Thromb Hacmost 1995:73:1404.
6. Morrissey JH, Macik BG. Ncuen-schwandcr PF. Comp PC: Quantitation of activated factor VII levels in plasma using a tissue factor mutant selectively deficient in promoting factor VII activation. Blood 1993: 81:734-744.
7. Hansen LL, Nielsen FE, Hedner U: Validation of method for determination of recombinant FVIIa coagulant activity in plasma using a one-stage clotting assay (abstract 1162). Thromb Hacmost 1993:69:865.