Effects of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine on intestinal polyp development in ApcΔ716 knockout mice

Molecular Carcinogenesis

Volumn 15, Issue 1, 1996, Pages 11-17

  Oshima, Masanobu ^a   Oshima, Hiroko ^a   Tsutsumi, Masahiro ^b   Nishimura, Susumu ^a   Sugimura, Takashi ^c   Nagao, Minako ^c   Taketo, Makoto M ^a  

^a TAIHO PHARMACEUTICAL CO LTD   (Japan)

^b NARA MEDICAL UNIVERSITY   (Japan)

^c NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

Author keywords

2 amino 3,8 dimethylimidazo 4,5 f quinoxaline; 2 amino 3 methylimidazo 4,5 f quinoline; Adenomatous polyposis coli (Apc) gene; Familial adenomatous polyposis; Heterocyclic amine; Knockout mice

Indexed keywords

2 AMINO 1 METHYL 6 PHENYLIMIDAZO[4,5 B]PYRIDINE; 2 AMINO 3 METHYLIMIDAZO[4,5 F]QUINOLINE; 2 AMINO 3,8 DIMETHYLIMIDAZO[4,5 F]QUINOXALINE; HETEROCYCLIC AMINE;

ADENOMATOUS POLYP; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COLON CARCINOGENESIS; COLON POLYP; COLON POLYPOSIS; CONTROLLED STUDY; GENE MUTATION; MOUSE; NONHUMAN; ONCOGENE; PRIORITY JOURNAL;

AGE FACTORS; ANIMALS; BODY WEIGHT; CARCINOGENS; DNA, NEOPLASM; FEMALE; GENES, APC; HETEROZYGOTE; HUMANS; IMIDAZOLES; INTESTINAL POLYPS; MALE; MICE; MICE, KNOCKOUT;

EID: 0030003582     PISSN: 08991987     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2744(199601)15:1<11::AID-MC3>3.0.CO;2-V     Document Type: Article

References (27)

1. Nagao M, Honda M, Seino Y, Yahagi T, Sugimura T. Mutagenicities of smoke condensates and the charred surface of fish and meat. Cancer Lett 2:221-226, 1977.
2. Felton JS, Knize MG. Occurrence, identification, and bacterial mutagenicity of heterocyclic amines in cooked food. Mutat Res 259:205-217, 1991.
3. Sugimura T. Studies on environmental chemical carcinogenesis in Japan Science 23:312-318, 1986.
4. Wakabayashi K, Nagao M, Esumi H, Sugimura T Food-derived mutagens and carcinogens Cancer Res (suppl) 52:2092-2098, 1992.
5. Shioya M, Wakabayashi K, Sato S, Nagao M, Sugimura T. Formation of a mutagen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in cooked beef, by heating a mixture containing creatinine, phenylalanine and glucose. Mutat Res 191:133-138, 1987.
6. Thompson LH, Tucker JD, Stewart SA, et al. Genotoxicity of compounds from cooked beef in repair-deficient CHO cells versus Salmonella mutagenicity. Mutagenesis 2:483-487, 1987.
7. Aeschbacher HU, Turesky RJ. Mammalian cell mutagenicity and metabolism of heterocyclic aromatic amines. Mutat Res 259 235-250, 1991.
8. Kadlubar FF, Kaderlik RK, Mulder GJ, et al. Metabolic activation and DNA adduct detection of PhIP in dogs, rats and humans in relation to urinary bladder and colon carcinogenesis. Princess Takamatsu Symp, in press
9. Takayama K, Yamashita K, Wakabayashi K, Sugimura T, Nagao M DNA modification by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in rats. Jpn J Cancer Res 80:1145-1148, 1989.
10. Nagaoka H, Wakabayashi K, Kim SB, et al. Adduct formation at C-8 of guanine on in vitro reaction of the ultimate form of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine with 2′-deoxyguanosine and its phosphate esters. Jpn J Cancer Res 83:1025-1029, 1992.
11. Frandsen H, Grivas S, Anderson R, Dragsted L, Larsen JC Reaction of the N2-acetoxyl derivative of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) with 2′-deoxyguanosine and DNA: Synthesis and identification of N2-(2′-deoxyguanosine-8-yl)-PhIP. Carcinogenesis 13:629-635, 1992
12. Lin D, Kederlik KR, Turesky RJ, Miller DW, Lay JO, Kadlubar FF. Identification of N-(deoxyguanosine-8-yl)-2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, with DNA. Chem Res Toxicol 5:691-697, 1992.
13. Esumi H, Ohgaki H, Kohzen E, Takayama S, Sugimura T Induction of lymphoma m CDF1 mice by the food mutagen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. Jpn J Cancer Res 80:1176-1178, 1989.
14. Ochiai M, Ogawa K, Wakabayashi K, et al. Induction of intestinal adenocarcinoma by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in Nagase analbuminemic rats. Jpn J Cancer Res 82:363-366, 1991.
15. Ito N, Hasegawa R, Sano M, et al. A new colon and mammary carcinogen in cooked food, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). Carcinogenesis 12:1503-1506, 1991.
16. Oshima M, Oshima H, Kitagawa K, Kobayashi K, Itakura C, Taketo M. Apc gene loss of heterozygosity and abnormal tissue building found in nascent intestinal polyps in truncation mutant mice. Proc Natl Acad Sci USA 92:4482-4486, 1995.
17. Frandsen H, Rasmussen ES, Nielsen PA, Farmer P, Dragsted L, Larsen JC Metabolic formation, synthesis and genotoxioty of the N-hydroxy derivative of the food mutagen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). Mutagenesis 6:93-98, 1990.
18. Kaderlik KR, Minchin RF, Mulder GJ, et al. Metabolic activation pathway for the formation of DNA adducts of the carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in rat extrahepatic tissues Carcinogenesis 15: 1703-1709, 1994
19. Kakiuchi H, Watanabe M, Ushijima T, etal Specific 5′-GGGA-3′ → 5′-GGA-3′ mutation of the Apc gene in rat colon tumors induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. Proc Natl Acad Sci USA 92:910-914, 1995.
20. Nagao M, Sugimura T Carcinogenic factors in food with relevance to colon cancer development. Mutat Res 290:43-51, 1993.
21. Knudson AG Jr. Mutation and cancer: Statistical study of retinoblastoma. Proc Natl Acad Sci USA 68:820-823, 1971
22. Watkins BE, Esumi H, Wakabayashi K, Nagao M, Sugimura T Fate and distribution of 2-amino-1-methyl-6-phenylimidazo[4,5-fa]pyridine (PhIP) in rats Carcinogenesis 12:1073-1078, 1991.
23. Kakiuchi H, Ushijima T, Ochiai M, et al. Rare frequency of activation of the Ki-ras in rat colon tumors induced by heterocyclic amines, suggesting alternative mechanisms of human colon carcinogenesis. Mol Carcinog 8:44-48, 1993
24. Makino H, Ushijima T, Kakiuchi H, et al. Absence of p53 mutations in rat colon tumors induced by 2-amino-6-methyldipyrido[1,2,-a:3′,2′-d]imidazole, 2-amino-3-methylimidazo[4,5-f]quinoline, or 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. Jpn J Cancer Res 85:510-514, 1994
25. + in intestinal adenomas from Min mice. Cancer Res 54: 5947-5952, 1994.
26. Tucker JD, Carrano AV, Allen IMA, et al. In vivo cytogenic effects of cooked food mutagens. Mutat Res 77:65-69, 1989.
27. Aeschbacher H-U, Turesky RJ. Mammalian cell mutagenicity and metabolism of heterocyclic aromatic amines. Mutat Res 259:235-250, 1991.