New approach to solid phase synthesis of polyamide nucleic acids analogues (PNA) and PNA-DNA conjugates

Tetrahedron Letters

Volumn 37, Issue 20, 1996, Pages 3571-3574

  Stetsenko, Dmitry A ^a   Lubyako, Elena N ^a   Potapov, Viktor K ^a   Azhikina, Tatyana L ^a   Sverdlov, Evgeny D ^a  

^a SHEMYAKIN OVCHINNIKOV INSTITUTE OF BIOORGANIC CHEMISTRY   (Russian Federation)

Author keywords

[No Author keywords available]

Indexed keywords

NUCLEIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DNA SYNTHESIS; DRUG SYNTHESIS; REACTION ANALYSIS; TECHNIQUE;

EID: 0030002597     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/0040-4039(96)00624-7     Document Type: Article

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18. 3).
19. 2O and 0.05M DMAP in 2,6-lutidine - THF 1:9 v/v, 200 μ1, 10 min. (9) THF wash, 2×0.5 ml, 2×0.5 min (10) DCE wash, 2×0.5 ml, 2×0.5 min.
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23. 20 template with equimolar concentrations of counterparts.
24. 14 insertion. Conjugate 7a didn't stop DNA synthesis at 37°C.
25. 23.When present work had been almost finished another article related to the same subject appeared: Bergmann, F., Bannwarth, W., Tam, S. Tetrahedron Lett. 1995, 36, 6823-6826.