Dermal mast cell activation by autoantibodies against the high affinity IgE receptor in chronic urticaria

Journal of Investigative Dermatology

Volumn 106, Issue 5, 1996, Pages 1001-1006

  Niimi, Naomasa ^a   Francis, David M ^a   Kermani, Faiz ^a   O'Donnell, Brigid F ^a   Hide, Michihiro ^a   Kobza Black, Anne ^a   Winkelmann, Richard K ^b   Greaves, Malcolm W ^a   Barr, Robert M ^a  

^a ST THOMAS HOSPITAL   (United Kingdom)

^b MAYO CLINIC   (United States)

Author keywords

Basophil leukocytes; Fc RI; Histamine; Skin

Indexed keywords

HISTAMINE; IMMUNOGLOBULIN E RECEPTOR;

ARTICLE; AUTOIMMUNITY; CHRONIC URTICARIA; CONTROLLED STUDY; HUMAN; MAJOR CLINICAL STUDY; MAST CELL DEGRANULATION; PRIORITY JOURNAL;

EID: 0030002396     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1111/1523-1747.ep12338544     Document Type: Article

References (15)

1. Benyon RC, Lowman MA, Church MK: Human skin mast cells: their dispersion, purification and secretory characterization. J Immunol 138:861-867, 1987
2. Brand CU, Spath PJ, Hunziker T, Limat A, Braathen LR: Complement profiles in human skin lymph during the course of irritant contact dermatitis. Arch Dermatol Res 286:959-963, 1994
3. Champion RH: A practical approach to urticarial syndromes - a dermatologist's view. Clin Exp Allergy 20:221-224, 1990
4. Eady RAJ, Cowen T, Marshall TF, Plummer V, Greaves MW: Mast cell population density, blood vessel density and histamine content in normal skin. Br J Dermatol 100:623-633, 1979
5. Fiebiger E, Maurer D, Holub H, Reininger B, Hartmann G, Woisetschläger M, Kinet J-P, Stingl G: Serum IgG autoantibodies directed against the α-chain of Fc∈RI: A selective marker and pathogenic factor for a distinct subset of chronic urticaria patients. J Clin Invest 96:2606-2612, 1995
6. Grattan CEH, Wallington TB, Warin RP, Kennedy CTC, Bradfield JW: A serological mediator in chronic idiopathic urticaria - a clinical, immunological and histological evaluation. Br J Dermatol 114:583-590, 1986
7. Grattan CEH, Francis DM, Hide M, Greaves MW: Detection of circulating histamine releasing autoantibodies with functional properties of anti-IgE in chronic urticaria. Clin Exp Allergy 21,695-704, 1991
8. Grattan CEH, Francis DM, Slater NGP Barlow RJ, Greaves MW: Plasmapheresis for severe, unremitting, chronic urticaria. Lancet 339:1078-1080, 1992
9. Gruber BL, Baeza ML, Marchese MJ, Agnello V, Kaplan AP: Prevalence and functional role of anti-IgE autoantibodies in urticarial syndromes. J Invest Dermatol 90:213-217, 1988
10. Hide M, Francis DM, Grattan CEH, Hakimi J, Kochan JP, Greaves MW: Antoantibodies against the high-affinity IgE receptor as a cause of histamine release in chronic urticaria. N Engl J Med 328:1599-1604, 1993
11. Hide M, Francis DM, Grattan CEH, Barr RM, Winkelmann RK, Greaves MW: The pathogenesis of chronic idiopathic urticaria: new evidence suggests an autoimmune basis and implications for treatment. Clin Exp Allergy 24:624-627, 1994
12. MacGlashan DW, Jr. Releasability of human basophils: cellular sensitivity and maximal histamine release are independent variables. J Allergy Clin Immunol 91:605-615, 1993
13. Maurer D, Stingl G. Immunoglobulin E-binding structures on antigen presenting cells present in skin and blood. J Invest Dermatol 104:707-710, 1995
14. Riske F, Hakimi J, Mallamaci M, Griffin M, Pilson B, Tobkes N, Lin P, Danho W, Kochan J, Chizzonite R: High affinity human IgE receptor (Fc∈RI). Analysis of functional domains of the α-subunit with monoclonal antibodies. J Biol Chem 266:11245-11251, 1991
15. Siraganian RP: Refinements in the automated fluorometric histamine analysis system. J Immunol Methods 7:283-290, 1975