The isfA mutation inhibits mutator activity and processing of UmuD protein in Escherichia coli recA730 strains

Molecular and General Genetics

Volumn 250, Issue 6, 1996, Pages 674-680

  Bȩbenek, Anna ^a   Pietrzykowska, Irena ^a  

^a INSTITUTE OF BIOCHEMISTRY AND BIOPHYSICS   (Poland)

Author keywords

Antimutator activity; Escherichia coli; Inhibition of UmuD processing; IsfA; RecA730

Indexed keywords

BETA GALACTOSIDASE; MUTAGENIC AGENT; PROTEIN;

ARTICLE; CONTROLLED STUDY; ESCHERICHIA COLI; MUTAGENESIS; MUTATION; NONHUMAN; PLASMID; PRIORITY JOURNAL; PROTEIN PROCESSING; ULTRAVIOLET RADIATION;

EID: 0030001878     PISSN: 00268925     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02172978     Document Type: Article

References (36)

1. Bailone A, Sommer S, Knezevic J, Dutreix M, Devoret R (1991) A RecA protein mutant deficient in its interaction with the UmuDC complex. Biochimie 73 : 479-484
2. Bates H, Randall SK, Rayssiguier Ch, Bridges BA, Goodman MF, Radman M (1989) Spontaneous and UV-induced mutations in Escherichia coli strains with altered or absent DNA polymerase I. J Bacteriol 171 : 2480-2484
3. Battista JR, Ohta T, Nohmi T, Sun W, Walker GC (1990) Dominant negative umuD mutations decreasing RecA-mediated cleavage suggest roles for intact UmuD in modulation of SOS mutagenesis. Proc Natl Acad Sci USA 87 : 7190-7194
4. Bȩbenek A, Pietrzykowska I (1995) A new mutation in Escherichia coli K12, isfA, which is responsible for inhibition of SOS functions. Mol Gen Genet 248 : 103-113
5. Burckhard SE, Woodgate R, Scheuermann RH, Echols H (1988) UmuD mutagenesis protein of E. coli: overproduction, purification, and cleavage by RecA. Proc Natl Acad Sci USA 85 : 1811-1815
6. Craig NL, Roberts JW (1980) E. coli RecA protein-directed cleavage of phage Z. repressor requires polynucleotide. Nature 283 : 26-30
7. Dutreix M, Moreau PL, Bailone A, Galibert F, Battista JR, Walker GC, Devoret R (1989) New recA mutations that dissociate the various RecA protein activities in Escherichia coli provide evidence for an additional role for RecA protein in UV mutagenesis. J Bacteriol 171 : 2415-2423
8. Dutreix M, Burnett B, Bailone A, Radding CM, Devoret R (1992) A partially deficient mutant, recA1730, that fails to form normal nucleoprotein filaments. Mol Gen Genet 232 : 489-497
9. Echols H, Goodman ME (1990) Mutation induced by DNA damage: a many-protein affair. Mutation Res 236 : 301-311
10. Ennis DG, Levine AS, Koch WH, Woodgate R (1995) Analysis of recA mutants with altered SOS functions. Mutation Res 336 : 39-48
11. Frank HG, Hauser J, Levine AS, Woodgate R (1993) Targeting of the UmuD, UmuD′ and MucA′ mutagenesis proteins to DNA by RecA protein. Proc Natl Acad Sci USA 90 : 8169-8173
12. Henry MF, Cronan JE Jr (1991) Direct and general selection for lysogens of Escherichia coli by phage Z recombinant clones. J Bacteriol 173 : 3724-3731
13. Joyce CM, Grindley NDF (1984) Method for determining whether a gene of Escherichia coli is essential: application to the polA gene. J Bacteriol 158 : 636-643
14. Kowalczykowski SC, Dixon DA, Eggleston AK, Lauder SD, Rehrauer WA (1994) Biochemistry of homologous recombination in Escherichia coli. Microbiol Rev 58 : 401-465
15. Laemmli UK (1970) Cleavage of structural proteins during the assembly of a head of bateriophage T4. Nature 227 : 680-685
16. Little JW (1991) Mechanism of specific LexA cleavage: autodigestion of RecA coprotease. Biochimie 73 : 411-422
17. Lu C, Echols H (1887) RecA protein and SOS: correlation of mutagenesis phenotype with binding of mutant RecAs to duplex DNA and LexA cleavage. J Mol Biol 196 : 597-604
18. Marsh L, Walker GC (1985) Cold sensitivity induced by overproduction of UmuDC in Escherichia coli. J Bacteriol 162 : 155-161
19. Miller JH (1972) Experiments in molecular genetics. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York
20. Nohmi T, Battista JR, Dodson LA, Walker GC (1988) RecA-mediated cleavage activates UmuD for mutagenesis: mechanistic relationship between transcriptional derepression and post translational activation. Proc Natl Acad Sci USA 85 : 1816-1820
21. Rosenberg M, Echols H (1990) Differential recognition of ultraviolet lesions by RecA protein. J Biol Chem 265 : 20641-20645
22. Sambrook J, Fritsch EF, Maniatis T (1989) Molecular cloning. A laboratory manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York
23. Sassanfar M, Roberts JW (1990) Nature of the SOS-inducing signal in Escherichia coli. The involvement of DNA replication. J Mol Biol 212 : 79-96
24. Sedgwick SG, Bridges BA (1972) Survival, mutation and capacity to repair single-stranded DNA breaks after gamma irradiation in different exr strains of Escherichia coli. Mol Gen Genet 119 : 93-102
25. Shinagawa H, Iwaski H, Kato T, Nakata A (1988) RecA protein-dependent cleavage of UmuD protein and SOS mutagenesis. Proc Natl Acad Sci USA 85 : 1806-1810
26. Shinagawa H, Kato T, Ise T, Makino K, Nakata A (1983) Cloning and characterisation of the umu operon responsible for inducible mutagenesis in E. coli. Gene 23 : 167-174
27. Sommer S, Bailone A, Devoret R (1993) The appearance of the UmuD′C protein complex in Escherichia coli switches repair from homologous recombination to SOS mutagenesis. Mol Microbiol 10 : 963-971
28. Story RM, Weber IT, Steitz TA (1992) The structure of E. coli recA protein monomer and polymer. Nature 355 : 318-325
29. Sweasy JB, Witkin EM, Sinha N, Roegner-Maniscalco V (1990) RecA protein of E. coli has a third essential role in SOS mutator activity. J Bacteriol 172 : 3030-3036
30. Vogel HL, Bonner DM (1956) Acetylornithinase of Escherichia coli: partial purification and some properties. J Biol Chem 218 : 97-106
31. Walker GC (1984) Mutagenesis and inducible responses to deoxyribonucleic acid damage in Escherichia coli. Microbiol Rev 48 : 60-93
32. Walker GC (1987) The SOS response of Escherichia coli. In Escherichia coli and Salmonella typhimurium: cellular and molecular biology. Am Soc Microbiol. Washington, DC. 1346-1357
33. Witkin EM, McCall JO, Volkert MR, Wermundson IE (1982) Constitutive expression of SOS functions and modulation of mutagenesis resulting from resolution of genetic instability at or near the recA locus of Escherichia coli. Mol Gen Genet 185 : 43-50
34. Witkin HM, Kogoma T (1984) Involvement of the activated form of RecA protein in SOS mutagenesis and stable DNA replication in Escherichia coli. Proc Natl Acad Sci USA 81 : 7539-7543
35. Woodgate R, Ennis DG (1991) Levels of chromosomally encoded Umu proteins and requirements for in vivo UmuD cleavage. Mol Gen Genet 229 : 10-16
36. Woodgate R, Rajagopalan M, Lu C, Echols H (1989) UmuC mutagenesis protein of Escherichia coli: purification and interaction with UmuD and UmuD′. Proc Natl Acad Sci USA 88 : 7301-7305