Developmental effects of d-sotalol on anterograde and retrograde atrioventricular conduction in the rabbit

Journal of Cardiovascular Electrophysiology

Volumn 7, Issue 5, 1996, Pages 406-414

  Case, Christopher L ^a   Le, Francis K ^a   Mckay, Christine A ^a   Gillette, Paul C ^a   Hewett, Kenneth W ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

atrioventricular conduction; atrioventricular node; d sotalol; developmental effects; recovery process

Indexed keywords

ANTIARRHYTHMIC AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; SOTALOL;

ANIMAL EXPERIMENT; ANTIARRHYTHMIC ACTIVITY; ARTICLE; ATRIOVENTRICULAR CONDUCTION; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; ELECTROCARDIOGRAM; HEART ELECTROPHYSIOLOGY; HEART MUSCLE REFRACTORY PERIOD; NEWBORN; NONHUMAN; POSTNATAL DEVELOPMENT; PRIORITY JOURNAL; RABBIT;

EID: 0030001781     PISSN: 10453873     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1540-8167.1996.tb00546.x     Document Type: Article

References (13)

1. Hohnloser SH, Woosley RL: Sotalol. N Engl J Med 1994;331:31-38.
2. Maragnès P, Tipple M, Fournier A: Effectiveness of oral sotalol for treatment of pediatric arrhythmias. Am J Cardiol 1992;69:751-754.
3. Tipple M, Sandor G: Efficacy and safety of oral sotalol in early infancy. PACE 1991;14(Pt II):2062-2065.
4. Hewett KW, Gaymes CH, Noh C, et al: Cellular electrophysiology of the neonatal and adult rabbit atrioventricular node. Am J Physiol 1991;260: H1674-1684.
5. Nayebpour M, Talajic M, Nattel S: Quantitation of dynamic AV nodal properties and application to predict rate-dependent AV conduction. Am J Physiol 1991;261:H292-H300.
6. Carmeliet EE: Electrophysiologic and voltage clamp analysis of the effects of sotalol on isolated cardiac muscle and Purkinje fibers. J Pharmacol Exp Ther 1984;232:817-825.
7. Hayward RP, Taggart P: Effect of sotalol on human atrial action potential duration and refractoriness: Cycle length dependency of class III activity. Cardiovasc Res 1986;20:100-107.
8. Yabek SM, Kato R, Ikeda N, et al: Cellular electrophysiologic responses of isolated neonatal and adult cardiac fibers to d-sotalol. J Am Coll Cardiol 1988; 11:1094-1099.
9. Moak JP: Developmental cellular electrophysiologic effects of d-sotalol on canine cardiac Purkinje fibers. Pediatr Res 1991;29:104-109.
10. Lathrop DA: Electromechanical characterization of the effects of racemic sotalol and its optical isomers on isolated canine ventricular trabecular muscles and Purkinje strands. Can J Physiol Pharmacol 1985;63:1506-1512.
11. Berger F, Borchard U, Hafner D: Effects of (+)- and (±)-sotalol on repolarizing outward currents and pacemaker current in sheep cardiac Purkinje fibres. Naunyn Schmiedebergs Arch Pharmacol 1989;340: 696-704.
12. Houyel L, Fournier A, Ducharme G, et al: Electrophysiologic effects of sotalol on the immature mammalian heart. J Cardiovasc Pharmacol 1992;19:134-139.
13. McComb JM, McGovern B, McGowan JB, et al: Electrophysiologic effects of d-sotalol in humans. J Am Coll Cardiol 1987;10:211-217.