Hypertension, thermotolerance, and the "African gene": An hypothesis

Clinical and Experimental Hypertension

Volumn 18, Issue 1, 1996, Pages 1-19

  Moskowitz, David W ^a  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Alu; Angiotensin I converting enzyme; Essential hypertension; Sweating

Indexed keywords

ANGIOTENSIN 1 CONVERTING ENZYME; UNCLASSIFIED DRUG;

AFRICA SOUTH OF THE SAHARA; ESSENTIAL HYPERTENSION; ETHNOLOGY; GENETIC PREDISPOSITION; HUMAN; HYPOTHESIS; PREVALENCE; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; REVIEW; THERMAL EXPOSURE; THERMOREGULATION;

AFRICAN CONTINENTAL ANCESTRY GROUP; ANGIOTENSIN I; ANGIOTENSIN II; BODY TEMPERATURE REGULATION; GENE DELETION; HUMANS; HYPERTENSION; MUTAGENESIS, INSERTIONAL; PEPTIDYL-DIPEPTIDASE A; PREVALENCE; RENIN-ANGIOTENSIN SYSTEM; UNITED STATES;

EID: 0030001604     PISSN: 10641963     EISSN: None     Source Type: Journal    
DOI: 10.3109/10641969609082603     Document Type: Article

References (97)

1. Kaplan, NM. Clinical Hypertension, 5th ed. Baltimore, MD: Williams & Wilkins; 1990.
2. Wingo PA, Tong T, Bolden S. Cancer statistics, 1995. CA Cancer J. Clin. 1995;45:8-30.
3. Luft FC, Grim CE, Higgins JT Jr., Weinberger MH. Differences in response to sodium administration in normotensive white and black subjects. J. Lab. Clin. Med. 1977;90:555-562.
4. Whittle JC, Whelton PK, Seidler AJ, Klag MJ. Does racial variation in risk factors explain black-white differences in the incidence of hypertensive end-stage renal disease? Arch. Intern. Med. 1991;151:1359-1364.
5. United States Renal Data Systems 1991 Annual Report. Am. J. Kid. Dis. 1991;18 (Suppl. 2): 17-60.
6. Brancati FL, Whittle JC, Whelton PK, Seidler AJ, Klag MJ. The excess incidence of diabetic end-stage renal disease among blacks. A population-based study of potential explanatory factors. J.A.M.A. 1992;268:3079-3084.
7. Otten MW, Teutsch SM, Williamson DF, Marks JS. The effect of known risk factors on the excess mortality of black adults in the United States. J.A.M.A. 1990;263:845-850.
8. Tyroler HA, Hames CG. Hypertension and 20-year mortality in black residents of Evans County, Georgia. In: Hypertension in Blacks: Epidemiology, pathophysiology and treatment. Hall WD, Saunders E, Shulman NB, eds. Chicago, IL: Year Book Medical Publishers, Inc.; 1985:37-48.
9. Cooper ES. Cerebrovascular disease in blacks. In: Hypertension in Blacks: Epidemiology, pathophysioiogy and treatment. Hall WD, Saunders E, Shulman NB, eds. Chicago, IL: Year Book Medical Publishers, Inc.; 1985:83-105.
10. Ware DR. Future research issues: hypertension in blacks. In: Hypertension in Blacks: Epidemiology, pathophysiology and treatment. Hall WD, Saunders E, Shulman NB, eds. Chicago, IL: Year Book Medical Publishers, Inc.; 1985:239-249.
11. James SA. Psychosocial and environmental factors in black hypertension. In: Hypertension in Blacks: Epidemiology, pathophysiology and treatment. Hall WD, Saunders E, Shulman NB, eds. Chicago, IL: Year Book Medical Publishers, Inc.; 1985:132-143.
12. Williams DR. Black-White differences in blood pressure: the role of social factors. Ethnicity & Disease 1992;2:126-141.
13. Dyer AR, Elliott P, Shipley M, and the INTERSALT Cooperative Research Group. Urinary electrolyte excretion in 24 hours and blood pressure in the INTERSALT Study. II. Estimates of electrolyte-blood pressure associations corrected for regression dilution bias. Am. J. Epidemiol. 1994;139:940-951.
14. Jackson FLC. An evolutionary perspective on salt, hypertension, and human genetic variability. Hypertension 1991;17(suppl. I):I129-I132.
15. Williams RR, Dadone MM, Hunt SC, Jorde LB, Hopkins PN, Smith JB, Ash KO, Kuida H. In: Genetic Epidemiology of Coronary Heart Disease: Past. Present, and Future. New York, NY: Alan R. Liss, Inc.; 1984:419-442.
16. Sowell T. Ethnic America: a history. New York, NY: Basic Books, Inc.; 1981:1-353.
17. Holt TC. In: Harvard Encyclopedia of American Ethnic Groups. Themstrom S, ed. Cambridge, MA: Harvard Univ. Press; 1980:5-23.
18. Cavalli-Sforza LL, Bodmer WF. The genetics of human populations. San Francisco, CA, 1971.
19. Hartl DL, Clark AG. Principles of Population Genetics, 2nd ed. Sunderland, MA: Sinauer Associates, Inc.; 1989:1-682.
20. Chakraborty R, Szathmary EJE, eds. Diseases of complex etiology in small populations: ethnic differences and research approaches. New York, NY: Alan R. Liss, Inc.; 1985.
21. Darlu P, Sagnier PP, Bois E. Genealogical and genetical African admixture estimations, blood pressure and hypertension in a Caribbean community. Ann. Hum. Biol. 1990;17:387-397.
22. Walker WG, Neaton JD, Culter JA, Neuwirth R, Cohen JD for the MRFIT Research Group. Renal function change in hypertensive members of the Multiple Risk Factor Intervention Trial. Racial and treatment effects. J.A.M.A. 1992;268:3085-3091.
23. Harburg E, Erfurt JC, Hauenstein LS, Chape C, Schull WJ, Schork MA. Socio-ecological stress, suppressed hostility, skin color, and Black-White male blood pressure: Detroit. Psychosom. Med. 1973;35:276-296.
24. Keil JE, Tyroler HA, Sandifer SH, Boyle E Jr. Hypertension: effects of social class and racial admixture: the results of a cohort study in the black population of Charleston, South Carolina. Am. J. Public Health 1977;67:634-639.
25. Harburg E, Gleibermann L, Roeper P, Schork MA, Schull WJ. Skin color, ethnicity, and blood pressure. II. Detroit blacks. Am. J. Public Health 1978;68:1177-1188.
26. Levy SB, Talner LB, Coel MN, Holle R, Stone RA. Renal vasculature in essential hypertension: racial differences. Ann. Intern. Med. 1978;88:12-16.
27. Warren SE, O'Connor DT. Does a renal vasodilator system mediate racial differences in essential hypertension? Am. J. Med. 1980;69:425-429.
28. Peter SA. Syndrome X: implications for African Americans. J. Natl. Med. Assoc. 1992:84(3):215,230,252.
29. Fumo MT, Teeger S, Lang RM, Bednarz J, Sareli P, Murphy MB. Diurnal blood pressure variation and cardiac mass in American blacks and whites and South African blacks. Am. J. Hypertens. 1992;5:111-116.
30. Reed TE. Caucasian genes in American Negroes. Science 1969;165:762-768.
31. Adams J, Ward RH. Admixture studies and the detection of selection. Science 1973;180:1137-1143.
32. Chakraborty R, Kamboh MI, Nwankwo M, Ferrell RE. Caucasian genes in American blacks: new data. Am. J. Hum. Genet. 1992;50:145-155.
33. Akinkugbe OO. World epidemiology of hypertension in blacks. In: Hypertension in Blacks: Epidemiology. pathophysiology and treatment. Chicago, IL: Year Book Medical Publishers, Inc.; 1985:3-16.
34. Wilson TW, Grim CE. Biohistory of slavery and blood pressure differences in blacks today. A hypothesis. Hypertension 1991;17(suppl. I):I122-I128.
35. Poulter N, Khaw KT, Hopwood BEC, Mugambi M, Peart WS, Rose G, Sever PS. Blood pressure and its correlates in an African tribe in urban and rural environments. J. Epidemiol. Commun. Health 1984;38:181-186.
36. Kaufman J, Barkey N. Hypertension in Africa: an overview of prevalence rates and causal risk factors. Ethnicity & Disease 1993;3:S83-S101.
37. Davis FJ. Who is black? One nation's definition. University Park, PA: Pennsylvania State Univ. Press; 1991:1-204.
38. Engerman SL, Genovese ED, eds. Race and Slavery in the Western Hemisphere: Quantitative Studies. Princeton, NJ: Princeton Univ. Press; 1975.
39. Oliver R. The African Experience: Major themes in African history from earliest times to the present. New York, NY: Harper Collins Publishers, Inc.; 1991:1-284.
40. Gemery HA, Hogendorn JS, eds. The Uncommon Market: Essays in the Economic History of the Atlantic Slave Trade. New York, NY: Academic Press; 1979.
41. Although only recently appreciated, both West African and South African slaves descended from the people of Cameroon in West Africa (42). According to linguistic analysis, the speakers of proto-Bantu originated in the region between the Cross River (which flows into the Bight of Biafra near the Nigerian city of Calabar) and the country east of Mount Cameroon (ref. 42, p. 65). From these earliest Bantu-speaking people are descended the modern-day tribes of West Africa, and the populous Xhosa tribe now located in the Eastern State of South Africa (42).
42. Mostert N. Frontiers: The epic of South Africa's creation and the tragedy of the Xhosa people. New York, NY: Alfred A. Knopf; 1992.
43. Olmsted FL. A Journey in the Seaboard Slave States, with Remarks on their Economy. New York, NY: Dix & Edwards; 1856.
44. Primm JN. Lion of the Valley: St. Louis. Missouri. Boulder, CO: Pruett Publishing Co.; 1981:1-592.
45. Henri F. Black Migration: Movement North 1900-1920. Garden City, NY: Anchor Press/Doubleday; 1975:69.
46. Anonymous. Field to Factory: Afro-American Migration 1915-1940. St. Louis, MO: Missouri Historical Society; 1991:1-12.
47. Holdcroft A. Body Temperature Control in Anaesthesia. Surgery and Intensive Care. London, UK: Bailliere Tindall; 1980:12-14.
48. Pandolf KB, Sawka MN, Gonzalez RR, eds. Human Performance Physiology and Environmental Medicine at Terrestrial Extremes. Indianapolis, IN: Benchmark; 1988:1-637.
49. Guyton AC, Coleman TG, Cowley AV Jr, et al. Arterial pressure regulation. Overriding dominance of the kidneys in long-term regulation and in hypertension. Am. J. Med. 1972;52:584-594.
50. Guyton AC. Textbook of Medical Physiology. 8th ed. Philadelphia, PA: WB Saunders Co.; 1991:800-801.
51. Collins KJ, Crockford GW, Weiner JS. The local training effect of secretory activity on the response of eccrine sweat glands. J. Physiol. 1966;184:203-214.
52. Kirby CR, Convertino VA. Plasma aldosterone and sweat sodium concentrations after exercise and heat acclimation. J. Appl. Physiol. 1986;61:967-970.
53. Brayden DJ, Cuthbert AW, Lee CM. Human eccrine sweat gland epithelial cultures express ductal characteristics. J. Physiol. 1988;405:657-675.
54. Jones CJ, Bell CL, Quinton PM. Different physiological signatures of sweat gland secretory and duct cells in culture. Am. J. Physiol. 1988;255:C102-C111.
55. Krouse ME, Hagiwara G, Chen J, Lewiston NJ, Wine JJ. Ion channels in normal human and cystic fibrosis sweat gland cells. Am. J. Physiol. 257:C129-C140, 1989.
56. Sato F, Owen M, Matthes R, Sato K, Gisolfi CV. Functional and morphological changes in the eccrine sweat gland with heat acclimation. J. Appl. Physiol. 1990;69:232-236.
57. Wolf G, Neilson EG. Angiotensin II as a renal growth factor. J. Am. Soc. Neph. 1993;3:1531-1540.
58. Aladjem M, Fine BP, Lasker N, Bogden JD, Gardner JP, Kemp F, Miller M, Aviv A. Effects of essential hypertension and antihypertensive medications on sweat formation. J. Hypertension 1992;10:69-76.
59. Stein RL. The French Slave Trade in the Eighteenth Century: an Old Regime Business. Madison, WI: Univ. of Wisconsin Press; 1979:1-250.
60. Curtin PD. Epidemiology and the Slave Trade. Political Science Quarterly 1968;83 (2): 190-216.
61. Bradley DJ. Malaria. In: Disease and Mortality in Sub-Saharan Africa. Feachem RG, Jamison DT, eds. Oxford, UK: Oxford University Press; 1991:190-202.
62. Monath TP. Yellow fever. In: Tropical and Geographical Medicine. 2nd ed. Warren KS, Mahmoud AAF, eds. New York, NY: McGraw-Hill, Inc.; 1990:661-674.
63. Abu-Aisha H, Al-Aska AK. Heat-associated illnesses. In: Hunter's Tropical Medicine, 7th ed., Strickland GT, ed. Philadelphia, PA: WB Saunders Co.; 1991:134-139.
64. Middleton C, ed. Winds of revolution. TimeFrame AD 1700-1800. Alexandria, VA: Time-Life Books; 1990:122-133.
65. Stenn KS. The Skin. In: Cell and Tissue Biology: A Textbook of Histology. 6th ed. Weiss L, ed. Baltimore, MD: Urban and Schwarzenberg; 1988:539-572.
66. Pandolf KB, Gange RW, Latzka WA, Blank IH, Kraning KK H, Gonzalez RR. Human thermoregulatory responses during heat exposure after artificially induced sunburn. Am. J. Physiol. 1992;262:R610-R616.
67. This may explain why populations living in tropical areas are hyperpigmented, regardles of their racial origin, e.g. Caucasians on the Indian subcontinent, sub-Saharan Africans, Australian aborigines, Asiatic Pacific Islanders, and Amerindians of Central America.
68. Laliberte F, Laliberte M-F, Alhenc-Gelas F, Chevillard C. Cellular and subcellular immunohistochemical localization of angiotensin-converting enzyme in the rat adrenal gland. Lab. Invest. 1987;56:364-371.
69. Keane WF, Anderson S, Aurell M, de Zeeuw D, Narins RG, Povar G. Angiotensin converting enzyme inhibitors and progressive renal insufficiency. Current experience and future directions. Ann. Int. Med. 1989;111:503-516.
70. Kasiske BL, Kalil RSN, Ma JZ, Liao M, Keane WF. Effect of antihypertensive therapy on the kidney in patients with diabetes: a meta-regression analysis. Ann. Int. Med. 1993;118:129-138.
71. Lewis EJ, Hunsicker LG, Bain RP, Rohde RD. The effect of angiotensin-converting-enzyme inhibition in diabetic nephropathy. New Engl. J. Med. 1993;329:1456-1462.
72. Johnson RJ, Alpers CE, Yoshimura A, Lombardi D, Pritzl P, Floege J, Schwartz SM. Renal injury from angiotensin II-mediated hypertension. Hypertension 1992;19:464-474.
73. Bailie MD, Rector FC Jr., Seidin DW. Angiotensin II in arterial and renal venous plasma and renal lymph in the dog. J. Clin. Invest. 1971;50:119-126.
74. Campbell DJ. Circulating and tissue angiotensin systems. J. Clin. Invest. 1987;79:1-6.
75. Rosivall L, Rinder DF, Champion J, Khosla MC, Navar LG, Oparil S. Intrarenal angiotensin I conversion at normal and reduced renal blood flow in the dog. Am. J. Physiol. 1983;245:F408-F415.
76. Costerousse O, Jaspard E, Wei L, Corvol P, Alhenc-Gelas F. The angiotensin I-converting enzyme (kininase II): molecular organization and regulation of its expression in humans. J. Cardiovasc. Pharmacol. 1992;20(suppl. 9):S10-S15.
77. Soubrier F, Hubert C, Testut P, Nadaud S, Alhenc-Gelas F, Corvol P. Molecular biology of the angiotensin I converting enzyme: I. Biochemistry and structure of the gene. J. Hypertension 1993;11:471-476.
78. Newshome EA, Start C. Regulation in Metabolism. London, UK: John Wiley & Sons; 1973:121-124.
79. Bernstein KE, Berk BC. The biology of angiotensin II receptors. Am. J. Kid. Dis. 1993;22:745-754.
80. Cogan MG. Angiotensin II: a powerful controller of sodium transport in the early proximal tubule. Hypertension 1990;15:451-458.
81. + exchange in cortical brush-border membranes during compensatory growth of the rat kidney. Pflugers Arch. 1988;413:190-196.
82. + exchange in brush border vesicles from dogs with renal failure. Am. J. Physiol. 1982;243:F293-F299.
83. Rigat B, Hubert C, Alhenc-Gelas F, Cambien F, Corvol P, Soubrier F. An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels. J. Clin. Invest. 1990;86:1343-1346.
84. Okada N. Transfer RNA-like structure of the human Alu family: implications of its generation mechanism and possible functions. J. Molec. Evolution 1990;31:500-510.
85. Sinnett D, Richer C, Deragon J-M, Labuda D. Alu RNA secondary structure consists of two independent 7 SL RNA-like folding units. J. Biol. Chem. 1991;266:8675-8678.
86. Beldent V, Michaud A, Wei L, Chauvet MT, Corvol P. Proteolytic release of human angiotensin-converting enzyme. Localization of the cleavage site. J. Biol. Chem. 1993;268:26428-26434.
87. Costerousse O, Allegrini J, Lopez M, Alhenc-Geias F. Angiotensin I-converting enzyme in human circulating mononuclear cells: genetic polymorphism of expression in T-lymphocytes. Biochem. J. 1993;290:33-40.
88. Cambien F, Poirier O, Lecerf L, Evans A, Cambou J-P, Arveiler D, Luc, G, Bard JM, Bara L, Ricard S, Tiret L, Amouyel P, Alhenc-Gelas F, Soubrier F. Deletion polymorphism in the gene for angiotensin-converting enzyme is a potent risk factor for myocardial infarction. Nature 1992;359:641-644.
89. Ruiz J, Blanche H, Cohen N, Velho G, Cambien F, Cohen D, Passa P, Froguel P. Insertion/deletion polymorphism of the angiotensin-converting enzyme gene is strongly associated with coronary heart disease in non-insyulin-dependent diabetes mellitus. Proc. Natl. Acad. Sci. USA. 1994;91:3662-3665.
90. Schunkert H, Hense H-W, Holmer SR, Stender M, Perz S, Keil U, Lorell BH, Riegger GAJ. Association between a deletion polymorphism of the angiotensin-converting-enzyme gene and left ventricular hypertrophy. New Engl. J. Med. 1994; 330:1634-1638.
91. Duru K, Farrow S, Wang J-M, Lockette W, Kurtz T. Frequency of a deletion polymorphism in the gene for angiotensin converting enzyme is increased in African-Americans with hypertension. Am. J. Hypertension 1994;7:759-762.
92. Jeunemaitre X, Lifton RP, Hunt SC, Williams RR, Lalouel J-M. Absence of linkage between the angiotensin converting enzyme locus and huyman essential hypertension. Nature Genetics 1992; 1:72-75.
93. Higashimori K, Zhao Y, Higaki J, Kamitani A, Katsuya T, Nakura J, Miki T, Mikami H, Ogihara T. Association analysis of a polymorphism of the angiotensin converting enzyme gene with essential hypertension in the Japanese population. Biochem. Biophys. Res. Commun. 1993;191:399-404.
94. Schmidt S, van Hooft IM, Grobbee DE, Ganten D, Ritz E. Polymorphism of the angiotensin I converting enzyme gene is apparently not related to high blood pressure: Dutch Hypertension and Offspring Study. J. Hypertension 1993;11:345-348.
95. Armitage P, Berry G. Statistical Methods in Medical Research. 2nd ed. Boston, MA: Blackwell Scientific Publications; 1987:183.
96. Chiu, K.C., Moskowitz, D.W., Permutt, M.A. The role of the angiotensin-I converting enzyme gene in the pathogenesis of non-insulin-dependent diabetes mellitus. In: New Horizons in Diabetes Mellitus and Cardiovascular Disease. Schwartz, CJ and Born GVR, eds. Bangalore, India: Current Science; 1995:28-33.
97. Ferrannini E, Buzzigoli G, Bonadonna R, Giorico MA, Oleggini M, Graziadei L, Pedrineili R, Brandi L, Bevilacqua S. Insulin resistance in essential hypertension. New Engl. J. Med. 1987;317:350-357.