Effects of felodipine on the ischemic heart: Insight into the mechanism of cytoprotection

Cardiovascular Drugs and Therapy

Volumn 10, Issue 4, 1996, Pages 425-437

  Ferrari, R ^a   Cargnoni, A ^b   Bernocchi, P ^b   Gaia, G ^b   Benigno, M ^a   Pasini, E ^b   Pedersini, P ^b   Ceconi, C ^a  

^a UNIVERSITY OF BRESCIA   (Italy)

^b IRCCS   (Italy)

Author keywords

Calcium antagonist; Felodipine; Myocardial ischemia; Reperfusion

Indexed keywords

ADENOSINE TRIPHOSPHATE; CALCIUM; CALCIUM ANTAGONIST; CREATINE KINASE; CREATINE PHOSPHATE; FELODIPINE; GLUTATHIONE; NORADRENALIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALCIUM TRANSPORT; CELL PROTECTION; CONTROLLED STUDY; CREATINE KINASE BLOOD LEVEL; DIASTOLIC BLOOD PRESSURE; ENZYME ACTIVITY; HEART LEFT VENTRICLE PERFORMANCE; HEART MITOCHONDRION; HEART MUSCLE BLOOD FLOW; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; HEART PROTECTION; INOTROPISM; ISOLATED HEART; MALE; MITOCHONDRIAL RESPIRATION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RABBIT;

ADENOSINE TRIPHOSPHATE; ANALYSIS OF VARIANCE; ANIMALS; CALCIUM; CALCIUM CHANNEL BLOCKERS; DOSE-RESPONSE RELATIONSHIP, DRUG; FELODIPINE; GLUTATHIONE; MALE; MITOCHONDRIA, HEART; MYOCARDIAL ISCHEMIA; MYOCARDIAL REPERFUSION; MYOCARDIUM; PHOSPHOCREATINE; RABBITS; SARCOLEMMA;

EID: 0030001588     PISSN: 09203206     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF00051107     Document Type: Article

References (56)

1. Kloner RA, Braunwald E. Effects of calcium antagonists on infarcting myocardium. Am J Cardiol 1987;59:84B-89B.
2. Nayler WG. Calcium antagonists and the ischaemic myocardium. Int J Cadiol 1987;15:267-274.
3. Opie LH. Calcium channel antagonists, part I: Fundamental properties: Mechanisms, classification, sites of action. Cardiovasc Drugs Ther 1987;1:411-430.
4. Kirkels JH, Ruigrok TJC, Van Echteld CJA, Meijler FL. Protective effect of pretreatment with the calcium antagonist anipamil on the ischaemic-reperfused rat myocardium: A phosphorus-31 nuclear magnetic resonance study. J Am. Coll Cardiol 1988;2:1087-1093.
5. Reimer KA, Jennings RB, Cobb FR, et al. Animal models for protecting ischaemic myocardium: Results of the NHLBI cooperative study comparison of unconscious and conscious dog models. Circ Res 1985;56:651-655.
6. Klein HH, Schubothe M, Nebendahl K, Kruezer H. The effects of two different treatments with diltiazem on infarct size in ischaemic, reperfused porcine hearts. Circulation 1984;69:1000-1005.
7. De Jong JW, Huizer T. Reduced glycolysis by nisoldipine treatment of ischaemic heart. J Cardiovasc Pharmacol 1985;7:497-500.
8. Lavanchy N, Martin J, Rossi A. Effects of diltiazem on the energy metabolism of the isolated rat heart submitted to ischemia: A phosphorus-31 nuclear magnetic resonance study. J Mol Cell Cardiol 1986;18:931-941.
9. Hoff PY, Tamura Y, Lucchesi BR. Cardioprotective effects of amlodipine in the ischemic-reperfused hearts. Am J Cardiol 1989;64:1011-1019.
10. Drake-Holland AJ, Noble MIM. Myocardial protection by calcium antagonist drugs. Eur Heart J 1983;4:823-825.
11. Ferrari R, Boffa GM, Ceconi C, et al. Effect of D-600 on ischemic and reperfused rabbit myocardium: Relation with timing and modality of administration. Basic Res Cardiol 1989;84:606-622.
12. Chaudhry A, Vohra MM. Depletion of cardiac noradrenaline stores by the calcium-channel blocker D-600. Can J Physiol Pharmacol 1984;62:640-644.
13. Brezinski ME, Darius H, Lefer AM. Cardioprotective action of a new calcium channel blocker in acute myocardial ischaemia. Drug Res 1986;36:464-466.
14. Higgins AJ, Blackburn KJ. Prevention of reperfusion damage in working rat hearts by calcium antagonists and calmodulin antagonists. J Mol Cell Cardiol 1984;16:427-438.
15. Dunselman PHJM, Kuntze CEE, Van Bruggen A, et al. Efficacy of felodipine in congestive heart failure. Eur Heart J 1989;10:354-364.
16. Sangiorgio P, Di Pasquale G, Savonitto S, et al. Felodipine in chronic stable angina: A randomized, double-blind, placebo-controlled, cross-over study. Eur Heart J 1990;10: 1011-1017.
17. Agostoni P, Doria E, Riva S, Polese A. Acute and chronic efficacy of felodipine in congestive heart failure. Int J Cardiol 1991;30:89-95.
18. Fariello R, Boni E, Corda L, et al. Extended release felodipine in essential hypertension. Variations in blood pressure during whole-day continuous ambulatory recording. Am J Hypertens 1991;4:27-33.
19. Wester A, Lorimer AR, Westberg B. Felodipine extended release in mild to moderate hypertension. Curr Med Res Opin 1991;12:275-281.
20. Ferrari R, Curello S, Ceconi C, Cargnoni A, Pasini E, Visioli O. Cardioprotection by nisoldipine: Role of timing of administration. Eur Heart J 1993;14:1258-1272.
21. Ferrari R, Ceconi C, Curello S, et al. Oxygen mediated myocardial damage during ischaemia and reperfusion: Role of the cellular defences against oxygen toxicity. J Mol Cell Cardiol 1985;17:937-945.
22. Oliver TA. A spectrophotometric method for the determination of creatine phosphokinase and myokinase. Biochem J 1955;61:116-122.
23. Ceconi C, Condorelli E, Quinzanini M, Rodella A, Ferrari R, Harris P. Effect of cardiac failure in rats on myocardial concentrations of noradrenaline and on atrial ANP-bombesin and neurotensin-like immunoreactivity. Adv Myochem 1987;1:428-429.
24. Tietze F. Enzymatic method for quantitative determination of nanogram amounts of total and oxidized glutathione: Application to mannalian blood and other tissue. Anal Biochem 1969;27:502-522.
25. Ferrari R, Williams AJ. The role of mitochondria in myocardial damage occurring on post-ischaemic reperfusion. J Appl Cardiol 1986;1:501-519.
26. Sordahl LA, McCollum WB, Wodd WG, Schwartz A. Mitochondria and sarcoplasmic reticulum function in cardiac hypertrophy and failure. Am J Physiol 1973;244:497-502.
27. Peng GF, Rane JJ, Murphy ML, Straub KD. Abnormal mitochondrial oxidative phosphorylation of ischaemic myocardium reversed by calcium chelating agents. J Mol Cell Cardiol 1987;9:897-908.
28. Bradford MM. A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle for protein binding. Anal Biochem 1978;72:248-254.
29. Lamprecht W, Trautschold E. Adenosine-5′-triphosphate determination with hexokinase and glucose-6-phosphate dehydrogenase. In: Methods of Enzymatic Analysis. Bergmeyer HU, ed. New York: Academic Press, 1974:2021-2105
30. Reed KL, Bygrave FL. Methodology for in vitro studies of calcium transport. Anal Biochem 1975;67:44-51.
31. Ferrari R, Boraso A, Cargnoni A, Pasini E, Raddino R, Albertini A. Effects of anipamil on myocardial sarcolemmal and mitochondrial calcium transport, comparison with verapamil and nifedipine. Eur J Pharmacol 1990;189:149-161.
32. Sillen LS, Martell AE. Stability constants of metal-ions complexes. Chem Soc (Lond) Special Publication, 1981;17.
33. St. Louis PJ, Sulake PV. Isolation of sarcolemmal membranes from cardiac muscle. Int J Biochem 1976;7:547-583.
34. Bernocchi P, Ceconi C, Cargnoni A, Pedersini P, Curello S, Ferrari R. Extraction and assay of creatine phosphate, purine and pyridine in cardiac tissue by reversed-phase high-performance liquid chromatography. Anal Biochem 1994;222:374-379.
35. Sedlack J, Lindsay RH. Estimation of total protein-bound, and non protein sulphydryl groups in tissue Ellman's reagent. Anal Biochem 1968;25:192-205.
36. Schaper W, Lewi P, Flameng W, Gijpen L. Myocardial steal provided by coronary artery occlusion. Basic Res Cardiol 1973;68:3-20.
37. Bush LR, Li YP, Shlafer M, Jolly SR, Lucchesi BR. Protective effects of diltiazem during myocardial ischemia in isolated cat hearts. J Pharmacol Exp Ther 1981;218:653-661.
38. De Jong JW, Huizer T, Tijseen JGP. Energy conservation by nisoldipine in ischaemic heart. Br J Pharmac 1984;83: 943-949.
39. Holt WW, Wendland MF, Derucin N, Wolfe C, Saeed M, Higgins CB. Effects of nicardipine, a calcium antagonist, on myocardial salvage and high energy phosphate stores in reperfused myocardial injury. J Am Coll Cardiol 1990;16: 1736-1744.
40. Boraso A, Cargnoni A, Comini L, Gaia G, Bernocchi P, Ferrari R. Effect of lacidipine on ischaemic and reperfused isolated rabbit hearts. Mol Cell Biochem 1993;125:73-86.
41. Ferrari R, Pedersini P, Bongrazio M, Gaia G, Bernocchi P, Di Lisa F, Visioli O. Mitochondrial energy production and cation control in myocardial ischaemia and reperfusion. Basic Res Cardiol 1993;88:495-512.
42. Henry PD, Shuchleib R, Davis J, Weiss ES, Sobel BE. Myocardial contracture and accumulation of mitochondrial calcium in ischemic rabbit heart. Am J Physiol 1977;233: H677.
43. Nayler WG, Ferrari R, Williams A. Protective effect of pretreatment with verapamil, nifedipine, and propranolol on mitochondrial function in the ischemic and reperfused myocardium. Am J Cardiol 1980;46:242-248.
44. Bourdillon PDV, Poole-Wilson PA. The effects of verapamil, quiescence and cardioplegia on calcium exchange and mechanical function in ischemic rabbit myocardium. Circ Res 1982;50:360-368.
45. Henry PD, Wahl AM. Diltiazem and nitrendipine suppress hypoxic contracture in quiescent ventricular myocardium. Eur Heart J 1983;4:819-822.
46. du Toit EF, Opie LH. Modulation of severity of reperfusion stunning in the isolated rat heart by agents altering calcium flux at onset of reperfusion. Circ Res 1992;70:960-967.
47. Park S-W, Tang X-L, Qiu Y, Sun J-Z, Bolli R. Nisoldipine attenuates myocardial stunning induced by multiple coronary occlusions in conscious pigs and this effect is independent of changes in hemodynamics or coronary blood flow. J Mol Cell Cardiol 1996;28:655-666.
48. Melin JA, Becker LC, Hutchins GM. Protective effect of early and late treatment with nifedipine during myocardial infarction in the conscious dog. Circulation 1984;69: 131-141.
49. Reibel DK, Rovetto MJ. Myocardial ATP synthesis and mechanical function following oxygen deficiency. Am J Physiol 1978;234:H620-H626.
50. Opie LH. Post-ischaemic stunning-the case for calcium as the ultimate culprit. Cardiovasc Drugs Ther 1991;5: 895-900.
51. Opie LH. Proposed role of calcium in reperfusion injury. Int J Cardiol 1989;23:159-164.
52. Sperelakis N. Cyclic AMP and phosphorylation in regulation of Ca influx into myocardial cells, and blockade by calcium antagonists drugs. Am Heart J 1984;107:347-357.
53. Nayler WG, Sturrock WJ. Inhibitory effect of calcium antagonists on the depletion of cardiac norepinephrine during post-ischaemic reperfusion. J Cardiovasc Pharmacol 1985; 7:581-587.
54. Mak II, Beglicki WB. Comparative antioxidant activities of propranolol nifedipine, verapamil and diltiazem against sarcolemmal membrane lipid peroxidation. Circ Res 1990; 66:1449-1452.
55. Opie LH. Reperfusion injury and its pharmacological modification. Circulation 1989;80:1049-1062.
56. Hearse DJ. Reperfusion-induced injury: A possible role for oxidant stress and its manipulation. Cardiovasc Drugs Ther 1991;5:225-236.