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Volumn 118, Issue 40, 1996, Pages 9509-9525

The total synthesis of dynemicin A leading to development of a fully contained bioreductively activated enediyne prodrug

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC ANTIBIOTIC; DYNEMICIN A; MITOMYCIN C;

EID: 0030001543     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja960040w     Document Type: Article
Times cited : (213)

References (61)
  • 3
    • 0030069884 scopus 로고    scopus 로고
    • For a personalized retrospective treatment of the biology and chemistry of the enediyne antibiotics, see: (a) Danishefsky, S. J.; Shair, M. D. J. Org. Chem., 1996, 61, 16.
    • (1996) J. Org. Chem. , vol.61 , pp. 16
    • Danishefsky, S.J.1    Shair, M.D.2
  • 4
    • 33646963759 scopus 로고
    • Ph.D. Thesis, Yale University
    • (b) See, also: Yoon, T. Y. Ph.D. Thesis, Yale University, 1994.
    • (1994)
    • Yoon, T.Y.1
  • 5
    • 0003815528 scopus 로고
    • Doyle, T. W., Borders, D. B., Eds.; Marcel-Decker: New York
    • (b) Enediyne Antibiotics as Antitumor Agents; Doyle, T. W., Borders, D. B., Eds.; Marcel-Decker: New York, 1994.
    • (1994) Enediyne Antibiotics as Antitumor Agents
  • 10
    • 3743114375 scopus 로고
    • Biological Properties of Esperamicin and Other Enediyne Antibiotics
    • Doyle, T. W., Borders, D. B., Eds., Marcel-Dekker: New York
    • (d) Casazza, A. M.; Kelley, S. L. Biological Properties of Esperamicin and Other Enediyne Antibiotics. In Enediyne Antibiotics as Antitumor Agents; Doyle, T. W., Borders, D. B., Eds., Marcel-Dekker: New York, 1994; pp 283-299.
    • (1994) Enediyne Antibiotics as Antitumor Agents , pp. 283-299
    • Casazza, A.M.1    Kelley, S.L.2
  • 19
    • 0000562654 scopus 로고
    • and references cited therein
    • For synthesis of various dynemicin A model systems, see: (a) Nicolaou, K. C.; Dai, W.-M. J. Am. Chem. Soc. 1992, 114, 8908 and references cited therein.
    • (1992) J. Am. Chem. Soc. , vol.114 , pp. 8908
    • Nicolaou, K.C.1    Dai, W.-M.2
  • 31
    • 33646954645 scopus 로고
    • Ph.D. Thesis, Columbia University
    • (b) Shair, M. D. Ph.D. Thesis, Columbia University, 1995.
    • (1995)
    • Shair, M.D.1
  • 35
    • 79251562395 scopus 로고
    • and references cited therein
    • Popp, F. D. Chem. Heterocycl. Comp. 1982, 32, 353 and references cited therein.
    • (1982) Chem. Heterocycl. Comp. , vol.32 , pp. 353
    • Popp, F.D.1
  • 37
    • 33646957729 scopus 로고
    • Ph.D. Thesis, Yale University
    • Taken in part from the following: Yoon, T. Y. Ph.D. Thesis, Yale University, 1994.
    • (1994)
    • Yoon, T.Y.1
  • 44
    • 3142525222 scopus 로고
    • For the only example of this type of construction to produce a cyclic enediyne in the context of an annulene synthesis, see: Huynh, C.; Linstrumelle, G. Tetrahedron 1988, 44, 6337.
    • (1988) Tetrahedron , vol.44 , pp. 6337
    • Huynh, C.1    Linstrumelle, G.2
  • 54
    • 0022785312 scopus 로고
    • For an excellent survey of methods to construct anthraquinone constructs, see: Krohn, K. Angew. Chem., Int. Ed. Engl. 1986, 25, 790.
    • (1986) Angew. Chem., Int. Ed. Engl. , vol.25 , pp. 790
    • Krohn, K.1
  • 58
    • 33847461709 scopus 로고    scopus 로고
    • 1H NMR spectrum matched well with a related model system
    • 1H NMR spectrum matched well with a related model system.
  • 59
    • 37049126729 scopus 로고
    • For the conversion of anthracenols to anthraquinones in the presence of ground state oxygen and light, see: (a) Cameron, D. W.; Schultz, P. E. J. Chem. Soc. (C) 1967, 2121.
    • (1967) J. Chem. Soc. (C) , pp. 2121
    • Cameron, D.W.1    Schultz, P.E.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.