Protein kinase C isozymes in human megakaryoblastic leukaemia cell line, MEG-01: Possible involvement of the isozymes in the differentiation process of MEG-01 cells

British Journal of Haematology

Volumn 93, Issue 4, 1996, Pages 762-771

  Nagata, Koh Ichi ^a   Okano, Yukio ^a   Nozawa, Yoshinori ^a  

^a GIFU UNIVERSITY   (Japan)

Author keywords

differentiation; isozymes; MEG 01 cells; megakaryoblasts; protein kinase C

Indexed keywords

ISOENZYME; MESSENGER RNA; PHORBOL ESTER; PROTEIN KINASE C;

ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; MEGAKARYOBLAST; PRIORITY JOURNAL;

EID: 0030001268     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.1996.d01-1714.x     Document Type: Article

References (30)

1. Aderem, A. (1992) The MARCKS brothers: a family of protein kinase C substrates. Cell, 71, 713-716.
2. Blackshear, P.J. (1993) The MARCKS family of cellular protein kinase C substrates. Journal of Biological Chemistry, 268, 1501-1504.
3. Bradford, M.M. (1976) A rapid and simple method for the quuntitation of quantities of protein utilizing the principle of protein-dye. Analytical Biochemistry, 72, 248-254.
4. Chen, C.-C. (1993) Protein kinase Cα, δ, ε and ζ in C6 glioma cells: TPA induces translocation and down-regulation of conventional and now PKC. FEBS Letters, 332, 169-173.
5. Chomczynski, P. & Sacchi, N. (1987) Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chlorolform extraction. Analytical Biochemistry, 162, 156-159.
6. Cook, P.P., Chen, J. & Ways, K. (1992) Interleukin-3 induces translocation and down-regulation of protein kinase C in human platelets. Biochemical and Biophysical Research Commununications, 185, 670-675.
7. Crabos, M., Imber, R., Woodtli, T., Fabbro, D. & Erne, P. (1991) Different translocation of three distinct PKC isoforms with tumor-promoting phorbol ester in human platelets. Biochemical and Biophysical Research Communications, 178, 878-883.
8. Dekker, L.V. & Parker, P.J. (1994) Protein kinase C: a question of specificity. Trends in Biochemical Science, 19, 73-77.
9. Drachman, J.G., Griffin, J.D. & Kaushansky, K. (1995) The C-Mpl ligand (thrombopoietin) stimulates tyrosine phosphorylation of Jak2, Shc, and C-Mpl. Journal of Biological Chemistry, 270, 4979-4982.
10. Duyster, J., Hidaka, H., Decker, K. & Dieter, P. (1992) Protein kinase Cβ isoform triggers the formation of prostanoids and superoxide in liver macrophages. Biochemical and Biophysical Research Communicaions, 183, 1247-1253.
11. Freire-Moar, J., Cherwinsk, H., Hwang, F., Ransom, J. & Webb, D. (1991) Expression of protein kinase C isozymes in thymocyte subpopulations and their differential regulation. Journal of Immunology, 147, 405-409.
12. Grabarek, J., Raychowdhury, M., Ravid, K., Kent, K.C., Newman, P.J. & Ware, J.A. (1992) Identification and functional characterization of protein kinase C isozymes in platelets and HEL cells. Journal of Biological Chemistry, 267, 10011-10017.
13. Gyllensten, U.B. & Erlich, H.A. (1988) Generation of single-stranded DNA by the polymerase chain reaction and its application to direct sequencing of the HLA-DQA locus. Proceedings of the National Academy of Sciences of the United States of America, 85, 7652-7656.
14. Hashimoto, K., Kishimoto, A., Aihara, H., Yasuda, I., Mikawa, K. & Nishizuka, Y. (1990) Protein kinase C during differentiation of human promyelocytic leukemia cell line, HL-60. FEBS Letters, 263, 31-34.
15. Horvath, A.R., Muszbek, L. & Kellie, S. (1992) Translocation of pp60C-SRC to the cytoskeleton during platelet aggregation. EMBO Journal, 11, 855-891.
16. Hug, H. & Sarre, T.F. (1993) Protein kinase C isozymes: divergence in signal transduction? Biochemical Journal, 291, 329-343.
17. 2+ and activators of protein kinase C on the plasma membrane association. Journal of Cell Biology, 107, 929-937.
18. Kaushansky, K. (1995) Thrombopoietin: the primary regulator of platelet production. Blood, 86, 419-431.
19. Laemmli, U.K. (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature, 227, 680-685.
20. Melloni, E., Pontremoli, S., Viotti, P.L., Patrone, M., Marks, P.A. & Rifkind, R.A. (1989) Differential expression of protein kinase C isozymes and erythroleukemia cell differentiation. Journal of Biological Chemistry, 264, 18414-18418.
21. Mischak, H., Bodenteich, A., Kolch, W., Goodnight, J., Hofer, F. & Mushinski, J.F. (1991) Mouse protein kinase C-δ the major isoform expressed in mouse hemopoietic cells: sequence of the DNA, expression patterns, and characterization of the protein. Biochemistry, 30, 7925-7931.
22. Nagata, K., Hattori, T., Hachiya, T., Takahashi, T. & Nozawa, Y. (1992) Purification and characterization of a low Mr GTP-binding protein, c25KG, from human platelet membranes. Biochimica et Biophysica Acta, 1160, 193-198.
23. Nagata, K. & Nozawa, Y. (1993) Subcellular localization of a low Mr GTP-binding protein, c25KG, in resting and stimulated human platelets. Biochemical and Biophysical Research Communications, 195, 1081-1088.
24. Nishizuka, Y. (1992) Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. Science, 258, 607-613.
25. Ogura, M., Morishima, Y., Ohno, R., Kato, Y., Hirabayashi, N., Nagura, H. & Saito, H. (1985) Establishment of a novel human megakaryoblastic leukemia cell line, MEG-01, with positive Philadelphia chromosome. Blood, 66, 1384-1392.
26. Ogura, M., Morishima, Y., Okumura, M., Hotta, T., Takamoto, S., Ohno, R., Hirabayashi, N., Nagura, H. & Saito, H. (1988) Functional and morphological differentiation induction of a human megakaryoblastic leukemia cell line (MEG-01s) by phorbol diesters. Blood, 72, 49-60.
27. Patrone, M., Pessino, A., Passalacqua, M., Sparatore, B., Melloni, E. & Pontremoli, S. (1994) Protein kinase C isoforms in murine erythroleukemia cells and their involvement in the differentiation process. FEBS Letters, 344, 91-95.
28. Tonetti, U.A., Henning-Chubb, C., Yamanishi, D.T. & Huberman, E. (1994) Protein kinase C-b is required for macrophage differentiation of human HL-60 leukemia cells. Journal of Biological Chemistry, 269, 23230-23235.
29. Wada, H., Ohno, S., Kubo, K., Taya, C., Tsuji, S., Yonehara, S. & Suzuki, K. (1989) Cell type-specific expression of the genes for the protein kinase C family: down-regulation of mRNAs for PKCo and nPKCε upon in vitro differentiation of a mouse neuroblastoma cell line neuro 2a. Biochemical and Biophysical Research Communications, 165, 533-538.
30. Ways, D.K., Cook, P.P., Webster, C. & Parker, P.J. (1992) Effect of phorbol esters on protein kinase C-ζ. Journal of Biological Chemistry, 267, 4799-4805.