A new approach for evaluation of the in vitro haemolytic potential of a solution of a new medicine

Comparative Haematology International

Volumn 6, Issue 1, 1996, Pages 35-41

  Dal Negro, G ^a   Cristofori, P ^a  

^a GSK   (Italy)

Author keywords

Haemolysis; Haemolytic potential; In vitro; Injection rate; Plasma haemoglobin; Plasma potassium

Indexed keywords

DIAZEPAM; DIGOXIN; HEMOGLOBIN; NEW DRUG; POTASSIUM ION; PROPYLENE GLYCOL;

ARTICLE; BLOOD FLOW VELOCITY; DRUG BLOOD LEVEL; HEMOLYSIS; INJECTION; POTASSIUM BLOOD LEVEL; VOLUMETRY;

EID: 0030001191     PISSN: 09387714     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF00368100     Document Type: Article

References (15)

1. Bonadonna R, Saccomani MP, Cobelli C et al. (1993a) Effect of insulin on system A aminoacid transport in human skeletal muscle. J Clin Invest 91:514-521
2. Bonadonna R, Del Prato S, Saccomani MF et al. (1993b) Transmembrane glucose transport in skeletal muscle of patients with noninsulin-dependent diabetes. J Clin Invest 92:486-494
3. Borsotti M, Pasquinelli F (1981) Acqua, Sodio, Potassio, Cloruri. In: Pasquinelli F. (ed) Diagnostica e tecniche di laboratorio, vol. 1, Rosini Editrice S.r.l. Firenze, p 1014
4. Fort FL, Heyman IA, Kesterson JW (1984) Hemolysis study of aqueous polyethylene glycol 400, propylene glycol and ethanol combinations in vivo and in vitro. J Parenter Sci Technol 38:82-87
5. Gurlo TG, Orlov SN, Aksentsev SL et al. (1991) Inward and outward potassium current rubidium-86 in human and rat erythrocytes regulation induced by changes in cell volume. Biol Membr 8:727-735
6. Kaji D (1986) Volume-sensitive potassium transport in human erythrocytes. J Gen Physiol 88:719-738
7. Obeng EK, Cadwallader DE (1989) In vitro dynamic method for evaluating the hemolytic potential of intravenous solutions. J Parenter Sci Technol 43:167-173
8. Pasquineili F, Piazza E (1981) Emoglobina In: Pasquinelli F (ed) diagnostica e tecniche di laboratorio, vol. 1: Rosini Editrice S.r.l. Firenze, pp 826-827
9. Prieur DJ, Young DM, Davis D et al. (1973) Procedures for preclinical toxicologie evaluation of cancer. Chemother Rep 4:1-39
10. Reed KW, Yalkowsky SH (1985) Lysis of human red blood cells in the presence of various cosolvents. J Parenter Sci Technol 39:64-68
11. Salauze D, Decouvelaere D (1994) In vitro assessment of the haemolytic potential of candidate drugs. Comp Haematol Int 4:3436
12. Shpakova NM, Bondarenko VA (1992) The sensitivity of erythrocytes to cold shock in media containing salts and nonelectrolytes. Probl Kryobiol 0,3:15-20
13. Ward GH, Yalkowsky SH (1992) The role of the effective concentration in interpreting hemolysis data. J Parenter Sci Technol, 46:161162
14. Ward GH, Yalkowsky SH (1993) Studies in phlebitis V: hemolysis as a model for phlebitis. J Parenter Sci Technol 48:44-46
15. Ward GH, Yalkowsky SH (1993b) studies of phlebitis IV: injection rate and amiodarone-induced phlebitis. J Parenter Sci Technol 47:40-43