Effect of calcium channel blockers on withdrawal syndrome of lorazepam in rats

Indian Journal of Medical Research

Volumn 103, Issue JUNE, 1996, Pages 310-314

  Gupta, M B ^a,b   Nath, C ^a   Patnaik, G K ^b   Saxena, R C ^a  

^a KING GEORGE'S MEDICAL UNIVERSITY   (India)

^b CENTRAL DRUG RESEARCH INSTITUTE   (India)

Author keywords

Calcium channel blockers; Lorazepam; Withdrawal syndrome

Indexed keywords

BENZODIAZEPINE DERIVATIVE; CALCIUM CHANNEL BLOCKING AGENT; LORAZEPAM; NIFEDIPINE; NIMODIPINE; VERAPAMIL;

AGGRESSION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUDIOGENIC SEIZURE; BODY TEMPERATURE; BODY WEIGHT; CONTROLLED STUDY; DOSE RESPONSE; FEMALE; FOOD INTAKE; HYPERKINESIA; HYPERTHERMIA; LOCOMOTION; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; RAT; REACTION TIME; WITHDRAWAL SYNDROME;

ACOUSTIC STIMULATION; AGGRESSION; ANIMALS; BODY TEMPERATURE; CALCIUM CHANNEL BLOCKERS; FEMALE; LORAZEPAM; MALE; MOTOR ACTIVITY; RATS; RATS, WISTAR; SEIZURES; SUBSTANCE WITHDRAWAL SYNDROME;

EID: 0030001118     PISSN: 09715916     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. Pucilowski O. Psychopharmacological properties of calcium channel inhibitors. Pychopharmacology 1992; 109 : 12-29.
2. 3 H]-nitrendipine binding sites in the morphine tolerant mice. Eur J Pharmacol 1984; 102 : 371-2.
3. Baeyens JM, Esposito E, Ossowska G, Samanin R. Effects of peripheral and central administration of calcium channel blockers in the naloxone - precipitated abstinence syndrome in morphine-dependent rats. Eur J Pharmacol 1987; 137 : 9-13.
4. Bongianni F, Carla V, Moroni F, Pellegrini-Giampietro DE. Calcium channel inhibitors suppress the morphine-withdrawal syndrome in rats. Br J Pharmacol 1986; 88 : 561-7.
5. 3H]-noradrenaline release. Br J Pharmacol 1988; 93 : 535-40.
6. Whittington MA, Dolin SJ, Patch TL, Siarey RJ, Butterworth, AR, Little HJ. Chronic dihydropyridine treatment can reverse the behavioural consequences of and prevent adaptations to, chronic ethanol treatment. Br J Pharmacol 1991; 103 : 1669- 76.
7. Tyrer PJ, Seivewright N. Identification and management of benzodiazepine dependence. Postgrad Med J 1984; 60 Suppl 2 : 41-6.
8. Wood JH, Katz JL, Winger G. Abuse and therapeutic use of benzodiazepines and benzodiazepine - like drugs. In: Bloom FE, Kupfer DJ, editors. Psychopharmacology, The fourth generation of progress. New York : Raven Press. 1995: 1777- 92.
9. Gupta GP, Gupta MB, Nath C, Srimal RC, Dhawan BN. Development of physical dependence with lorazepam and lorazepam diphenhydramine combination in rats. Psychopharmacology 1988; 96 Suppl : 200.
10. Gupta MB, Nath C, Bhalla DN, Patnaik GK, Dhawan KN. Comparative evaluation of physical dependence of some benzodiazepines in rats. Ann Neurosci 1993; 4 : 13-8.
11. Yanaura S, Tagashira E, Suzuki T. Physical dependence on morphine, phenobarbital and diazepam in rats by drug-admixed food ingestion. Jpn J Pharmacol 1975; 25 : 453-63.
12. Freireich EJ. Quantitative comparison of toxicity of anticancer agents in mouse, rat, dog. monkey and man. Cancer Chemother Rep 1966; 50 : 219-44.
13. Dew PB. The measurement of the influence of drugs on locomotor activity of mice. Br J Pharmacol 1953; 8 : 46-8.
14. Chen G. The anti-tremorine effect of some drugs as determined by Haffner's method of testing analgesia in mice. J Pharmacol Exp Ther 1958; 124 : 73-6.
15. Tedeschi RE, Tedeschi DH, Muchs A, Cook L, Mattis PA, Fellows EJ. Effects of various centrally acting drugs on fighting behavior of mice. J Pharmacol Exp Ther 1959; 125 : 28-34.
16. Essig CF. Barbiturate withdrawal in white rats. Int J Neuropharmacol 1966; 5 : 103-7.
17. Nath C, Gupta MB, Shanker K, Gupta GP, Srimal RC, Dhawan BN. Effect of diphenhydramine on withdrawal syndrome of some psychoactive drugs. In: Dhawan BN, Srimal RC, Raghubir R, Rapaka RS, editors. Recent advances in the study of neurotransmitter receptors. Lucknow : Central Drug Research Institute, 1994 : 310-8.
18. Hoffmeister F, Benz U, Heise A, Krause HP, Neuser V. Behavioral effects of nimodipine in animals. Arzneimittel Forschung/Drug Res 1982; 32 : 347-61.
19. Mogilnicka E, Czyrak A, Maj J. Dihydropyridine calcium channel antagonists reduce immobility in the mouse behavioural despair test; antidepressants facilitate Nifedipine action. Eur J Pharmacol 1987; 138 : 413-6.
20. Rall TW. Hypnotics and sedatives : Ethanol. In: Gillman AG, Rall TW, Nies AS, Taylor P, editors. Goodman and Gilman's the pharmacological basis of therapeutics. 8th ed. New York: Pergamon Press, 1990 : 345-82.
21. Jhonston GAR. Neuropharmacology of amino acid inhibitory neurotransmitters. Annu Rev Pharmacol Toxicol 1978; 18 : 269-89.
22. Wood JH, Katz JL, Winger G. Benzodiazepines: use, abuse and consequences. Pharmacol Rev 1992; 44 : 151-347.
23. Godfraind T, Miller R, Wibo M. Calcium antagonism and calcium entry blockade. Pharmacol Rev 1986; 38 : 321-416.