Depressor action of L-threo-dihydroxyphenylserine in the rat nucleus tractus solitarii

European Journal of Pharmacology

Volumn 300, Issue 1-2, 1996, Pages 105-108

  Miyamae, Takeaki ^a   Yue, Jin Liang ^a   Goshima, Yoshio ^a   Misu, Yoshimi ^a  

^a YOKOHAMA CITY UNIVERSITY   (Japan)

Author keywords

L DOPA (L dihydroxyphenylalanine); L DOPA methyl ester; L threo DOPS (L threo dihydroxyphenylserine); Neurotransmitter; Nucleus tractus solitarii; Rat

Indexed keywords

3 HYDROXYBENZYLHYDRAZINE; AROMATIC LEVO AMINO ACID DECARBOXYLASE INHIBITOR; GLUTAMIC ACID; LEVODOPA; NORADRENALIN; THREO 3,4 DIHYDROXYPHENYLSERINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING SITE; BRADYCARDIA; CONTROLLED STUDY; DEPRESSOR RESPONSE; DRUG ANTAGONISM; DRUG MECHANISM; HISTOLOGY; INTRAPERITONEAL DRUG ADMINISTRATION; ISOMER; MALE; MICROINJECTION; NONHUMAN; PRIORITY JOURNAL; RAT; SOLITARY TRACT NUCLEUS;

EID: 0030000630     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-2999(95)00875-6     Document Type: Article

References (15)

1. Bartholini, G., J. Constantinidis, M. Puig, R. Tissot and A. Pletscher, 1975, The stereoisomers of 3,4-dihydroxyphenylserine as precursors of norepinephrine, J. Pharmacol. Exp. Ther. 193, 523.
2. Birkmayer, W., G. Birkmayer, H. Lechner and P. Riederer, 1983, D,L-3,4-threo-DOPS in Parkinson's disease: effects on orthostatic hypotension and dizziness, J. Neural Transm. 58, 305.
3. Carlsson, A., 1964, Functional significance of drug-induced changes in brain monoamine levels, Prog. Brain Res. 8, 9.
4. 3H]AMPA binding in rat striatum, Neurosci. Lett. 132, 55.
5. 2-adrenoceptors under essentially complete inhibition of L-aromatic amino acid decarboxylase in rat hypothalamic slices, Jpn. J. Pharmacol. 53, 47.
6. Goshima, Y., S. Nakamura and Y. Misu, 1991, L-Dihydroxyphenylalanine methyl ester is a potent competitive antagonist of the L-dihydroxyphenylalanine-induced facilitation of the evoked release of endogenous norepinephrine from rat hypothalamic slices, J. Pharmacol. Exp. Ther. 258, 466.
7. Kubo, T. and Y. Misu, 1981, Pharmacological characterization of the alpha-adrenoceptors responsible for a decrease of blood pressure in the nucleus tractus solitarii of the rat, Naunyn-Schmied. Arch. Pharmacol. 317, 120.
8. Kubo, T., J.-L. Yue, Y. Goshima, S. Nakamura and Y. Misu, 1992, Evidence for L-DOPA systems responsible for cardiovascular control in the nucleus tractus solitarii of the rat, Neurosci. Lett. 140, 153.
9. Misu, Y., H. Ueda and Y. Goshima, 1995, Neurotransmitter-like actions of L-DOPA, Adv. Pharmacol. 32, 427.
10. Nakamura, S., Y. Goshima, J.-L. Yue, T. Miyamae and Y. Misu, 1992, Transmitter-like 3,4-dihydroxyphenylalanine is tonically released by nicotine in striata of conscious rats, Eur. J. Pharmacol. 222, 75.
11. Narabayashi, H., Y. Kondo, A. Hayashi, T. Suzuki and T. Nagatsu, 1981, L-threo-3,4-Dihydroxyphenylserine treatment for akinesia and freezing of parkinsonism, Proc. Jpn. Acad. 57 Ser. B, 353.
12. Nishino, N., Y. Fujii, M. Kondo, H. Shuntoh, H. Fujiwara and T. Tanaka, 1987, Effects of L-threo-3,4-dihydroxyphenylserine on efflux of monoamines and acetylcholine in guinea pig brain, J. Pharmacol. Exp. Ther. 242, 621.
13. Yue, J.-L., Y. Goshima, S. Nakamura and Y. Misu, 1992, L-DOPA-like regulatory actions of L-threo-3,4-dihydroxyphenylserine on the release of endogenous noradrenaline via presynaptic receptors in rat hypothalamic slices, J. Pharm. Pharmacol. 44, 990.
14. Yue, J.-L., Y. Goshima, T. Miyamae and Y. Misu, 1993, Evidence for L-DOPA relevant to modulation of sympathetic activity in the rostral ventrolateral medulla of rats, Brain Res. 629, 310.
15. Yue, J.-L., H. Okamura, Y. Goshima, S. Nakamura, M. Geffard and Y. Misu, 1994, Baroreceptor-aortic nerve-mediated release of endogenous L-3,4-dihydroxyphenylalanine and its tonic depressor function in the nucleus tractus solitarii of rats. Neuroscience 62, 145.