Cocaine uptake is decreased in the brain of detoxified cocaine abusers

Neuropsychopharmacology

Volumn 14, Issue 3, 1996, Pages 159-168

  Volkow, N D ^a,b   Wang, G J ^a   Fowler, J S ^a   Logan, J ^a   Hitzemann, R ^b,c   Gatley, S J ^a   MacGregor, R R ^a   Wolf, A P ^a  

^a BROOKHAVEN NATIONAL LABORATORY   (United States)

^b STONY BROOK UNIVERSITY   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

CBF; Dopamine receptors; Dopamine transporter; Drug dependence; 18F N methylspiroperidol; 11C Cocaine

Indexed keywords

COCAINE; DOPAMINE 2 RECEPTOR; SPIPERONE;

ADULT; ARTICLE; BRAIN TISSUE; CLINICAL ARTICLE; CONTROLLED STUDY; DETOXIFICATION; DRUG ABUSE; DRUG DISTRIBUTION; DRUG LABELING; DRUG UPTAKE; HUMAN; ISOTOPE LABELING; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL;

EID: 0030000509     PISSN: 0893133X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0893-133X(95)00073-M     Document Type: Article

References (65)

1. 3H]GBR-12935 binding after chronic treatment with dopamine active drugs. Psychopharmacology 102:291-294
2. Baker I, Wyatt RJ, Masserano (1993): Evaluation of dopamine uptake into the substantia nigra, ventral tegmental area and striatum of the rate: Effects of cocaine treatment. Society for Neuroscience 23rd Annual Meeting 19:936
3. Baxter LR, Schwartz JM, Phelps M, Mazziota JC, Barrio J, Rawson RA, Engel J, Guze BH, Selin C, Sumida R (1988): Localization of neurochemical effects of cocaine and other stimulants in the human brain. J Clin Psychiatry 4:923-926
4. Benmansour S, Tejani-Butt SM, Hauptmann M, Brunswick DJ (1992): Lack of effect of high-dose cocaine on monoamine uptake sites in rat brain measured by quantitative autoradiography. Psychopharmacology 106:459-462
5. Blinkov SM, Glezer II (1968): The Human Brain in Figures and Tables: A Quantitative Handbook. New York, Plenum, 166-170
6. Cerruti C, Pilotte NS, Uhl G, Kuhar MJ (1993): Reduction in dopamine transporter mRNA after cessation of repeated cocaine administration. Mol Brain Res 00:1-7
7. Choy-Kwang M, Lipton RB (1989): Dystonia related to cocaine withdrawal: A case report and pathogenic hypotheses. Neurology 39:996-997
8. Dackis CA, Gold MS (1985): New concepts in cocaine addiction: The dopamine depletion hypothesis. Neurosci Biobehav Rev 9:469-477
9. De Wit H, Wise RA (1977): Blockade of cocaine reinforcement in rats with the dopamine receptor blocker pimozide but not with the noradrenergic blockers phentolamine or phenoxybenzamine. Can J Psychol 31:195-203
10. 2 receptor mediated inhibition of acetylcholine release in rat striatum-indications for a common signal pathway. Neuroscience 37:1-9
11. Farfel GM, Kleven MS, Woolverton WL, Siden LS, Perry BD (1992): Effects of repeated injections of cocaine on catecholamine receptor binding sites, dopamine transporter binding sites, and behavior in rhesus monkey. Brain Res 578:235-243
12. Fischman MW, Schuster CR, Javaid J. Hatano Y, Davis J (1985): Acute tolerance development to the cardiovascular and subjective effects of cocaine. J Pharmacol Exp Ther 235: 677-682
13. Fowler JS, Volkow ND, Wolf AP, Dewey SL, Schlyer D, MacGregor RR, Hitzemann R, Logan J, Bendriem B, Gatley SJ, Christman D (1989): Mapping cocaine binding sites in human and baboon brain sites in vivo. Synapse 4:371-377
14. Graham JH, Dworkin SI, Porrino LJ (1994): Alterations in dopamine uptake transporter density in cocaine self administering rats appear transient. Society for Neurosciences Abstracts. 24th Annual Meeting 20:1627
15. Gold MS (1992): Cocaine and (crack): Clinical aspects. In Lowinson JH, Ruiz P, Millman RB, Langrod J (eds), Substance Abuse: A Comprehensive Textbook. Baltimore, Williams & Wilkins, pp 205-221
16. Hegarty A, Lipton RB, Merriam (1990): Cocaine as a risk factor for acute dystonic reaction (abst). Neurology 40 (suppl. 1):146-147
17. Hitri A, Wyatt RJ (1993): Regional differences in the effect of cocaine on rat brain dopamine transporter binding: Function of time after chronic administration. Clin Neuropharmacol 16:525-539
18. Hitri A, Casanova MF, Kleinman JE, Wyatt RJ (1994): Fewer dopamine transporter receptors in the prefrontal cortex of cocaine users. Am J Psychiatry 151(7):1074-1076
19. Hitzemann R, Burr G, Piscani K, Hazan J, Krishnamoorthy G, Cushman P, Baldwin CH, Carrion R, Volkow ND, Hirschowitz J, Handelsman L, Chiaramonte J, Angrist B (1995): Neuroendocrine and clinical features of cocaine withdrawal. Psychiatry Res (in press)
20. Hollander E, Nunes E, DeCaria C, Quitkin FM, Cooper Th, Wager S, Klein DF (1990): Dopaminergic sensitivity and cocaine abuse: response to apomorphine. Psychiatry Res 33:161-169
21. 11C] Flumazenil. J Cereb Blood Flow Metab 11:745-75
22. Hurd YL, Herkenham M (1993): Molecular alterations in the neostriatum of human cocaine addicts. Synapse 13:357-369
23. 3H]dopamine uptake in rat nucleus accumbens, but not in striatum. Brain Res 531:338-341
24. Izenwasser S, Cox BM (1992): Inhibition of dopamine uptake by cocaine and nicotine: Tolerance to chronic treatments. Brain Res 573:119-125
25. Johanson ChE, Fischman MW (1989): The pharmacology of cocaine related to its abuse. Pharmacol Rev 41:3-52
26. 2 receptors in post mortem human brain with [125I]epidepride. Brain Res 609:237-243
27. Koob GF, Bloom FE (1988): Cellular and molecular mechanism of drug dependence. Science 242:715-723
28. Kula NS, Baldessarini RJ (1991): Lack of increase in dopamine transporter binding or function in rat brain tissue after treatment with blockers of neuronal uptake of dopamine. Neuropharmacology 30:89-92
29. Kumor K, Sherer M, Jaffe J (1987): Haloperidol-induced dystonia in cocaine addicts. Lancet 2:1341-1342
30. 3H]WIN 35428 binding sites in human striatum. Brain Res 62:17-25
31. 11C-methyl]-(-)cocaine PET studies in human subjects. J Cereb Blood Flow Metab 10:740-747
32. 11C] raclopride binding in the brain: model simulations and kinetic analysis of PET data. J Cereb Blood Flow Metab 14:995-1010
33. London ED, Cascella NG, Wong DF, Phillips RL, Dannals RF, Links JM, Herning R, Grayson R, Jaffe JH (1990): Cocaine-induced reduction of glucose utilization in human brain. A study using positron emission tomography and [fluorine-18]-fluorodeoxyglucose. Arch Gen Psychiatry 47:567-574
34. Madras BK, Kaufman MJ (1994): Cocaine accumulates in dopamine-rich regions of primate brain after IV administration: Comparison with mazindol distribution. Synapse 18:261-275
35. Malison RT, Wallace EA, Best S, Gandelman M, Zoghbi SS, Zea Ponce Y, Baldwin RM, Charney DS, Hoffer PB, Kosten TR, Innis RB (1994): SPECT imaging of dopamine transporters in cocaine dependent and healthy control subjects with [123]βCIT. 24th Annual Meeting, Society for Neurosciences Abstracts 20:1625
36. Matsui T, Hirano A (1978): An Atlas of the Human Brain for Computerized Tomography. Stuttgart, Gustav Fisher Verlag
37. Missale C, Castelletti L, Govoni S, Spano PF, Trabucchi M, Hanbauer I (1985): Dopamine uptake is differently regulated in rat striatum and nucleus accumbens. J Neurochem 45:51-56
38. Mule SJ, Casella GA, Misra AL (1976): Intracellular disposition of [3H]-cocaine, [3H]-norcocaine, [3H]-benzoylecgonine, and [3H]-benzoilnorecgonine in the brain of rats. Life Sci 19:1585-1596
39. Ng JP, Hubert GW, Justice JB Jr (1991): Increased stimulated release and uptake of dopamine in nucleus accumbens after repeated cocaine administration as measured by in vivo voltarnmetry. J Neurochem 56:1485-1492
40. Pan HT, Meancherry S, Justice RB Jr (1991): Differences in the pharmacokinetics of cocaine in naive and cocaine-experienced rats. J Neurochem 1299-1306
41. 2 Antagonist Pimozide Inhibits Up-Regulation of Dopamine Release and Uptake Induced by Repeated Cocaine. Journal of Neurochemistry, New York, Raven, pp 376-379
42. Parsons LH, Smith AD, Justice JB Jr (1991): Based extracellular dopamine is decreased in the rat nucleus accumbens during abstinence from chronic cocaine. Synapse 9:60-65
43. Peris J, Boyson SJ, Cass WA, Curella P, Dwoskin LP, Larson G, Lin LH, Yasuda RP, Zahniser NR (1990): Persistence of neurochemical changes in dopamine systems after repeated cocaine administration. J Pharmacol Exp Ther 254:38-14
44. Pettit HO, Pan HT, Parson LH, Justice JB Jr (1990): Extracellular concentrations of cocaine and dopamine are enhanced during chronic cocaine administration. J Neurochem 55:798-804
45. Pilotte NS, Sharpe LG, Kuhar MJ (1994): Withdrawal of repeated intravenous infusions of cocaine persistently reduces binding to dopamine transporters in nucleus accumbens of lewis rats. JPET 269:963-969
46. Reith MEA, Benuck M, Lajtha A (1987): Cocaine disposition in the brain after continuous or intermittent treatment and locomotor stimulation in mice. J Pharmacol Exp Ther 243:281-287
47. Ritz MC, Lamb RJ, Goldber SR, Kuhar MJ (1987): Cocaine receptors on dopamine transporters are related to self administration of cocaine. Science 237:1219-1223
48. 11C]nonifensine uptake using positron emission tomography. J Cereb Blood Flow Metab 10:307-316
49. 3H-mazindol labeling of dopamine transporter in rat nucleus accumbens. Eur J Pharmacol 203:141-144
50. 2 receptor occupancy in schizophrenic patients. Biol Psychiatry 23:653-663
51. 2 receptor of dopamine stimulated efflux of cAMP and potassium stimulated release of acetylcholine from rat neostriatum. Brain Res 250:263-270
52. Volkow ND, Fowler JS, Wang G-J, Logan J, Schlyer D, Mac Gregor R, Hitzemann R, Wolf AP (1994): Decreased dopamine transporters with age in healthy human subjects. Ann Neurol 36:237-239
53. Volkow ND, Fowler JS, Wolf AP, Schlyer D, Schiue C-Y, Alpert R, Dewey SL, Logan J, Bendriem B, Christman D, Hitzemann R, Henn F (1990): Effects of chronic cocaine abuse on postsynaptic dopamine receptors. Am J Psychiatry 147:719-724
54. Volkow ND, Mullani N, Gould KL, Adler S, Krajewski K (1988): Cerebral blood flow in chronic cocaine users. Br J Psych 151:641-648
55. Volkow ND, Fowler JS, Wang G-J, Hitzemann R, Logan J, Schlyer D, Dewey S, Wolf AP (1993): Dopaminergic dysregulation of frontal metabolism may contribute to cocaine addiction. Synapse 14:169-177
56. 11C]cocaine binding at subpharmacologic and pharmacologic doses in baboon brain: A PET study. J Nucl Med 36:1289-1297
57. Volkow ND, Fowler JS, Wolf AP, Hitzemann R, Dewey S, Bendriem B, Alpert R, Hoff A (1991): Changes in brain glucose metabolism in cocaine dependence and withdrawal. Am J Psych 148:621-626
58. Volkow ND, Hitzemann R, Wang GJ, Fowler JS, Wolf AP, Dewey SL (1992): Long-term frontal brain metabolic changes in cocaine abusers. Synapse 11:184-190
59. Wang G-J, Volkow ND, Fowler JS, Wolf AP, MacGregor R, Shea CE, Shyler D, Hitzemann R (1993): Comparison of two PET radioligands for imaging extrastriatal dopamine receptors in human brain. Synapse 15:246-249
60. Wilson JM, Carrol M, Niznik HB, Kish SJ (1992): Differential regulation of the cocaine acceptor and dopamine uptake sites following cocaine self-administration. Soc Neurosci Abstr 18:1078
61. Wise RA (1990): Neural mechanisms of the reinforcing actions of cocaine. In Volkow ND, Swann A (eds), Cocaine in the Brain. New Brunswick, Rutgers University Press, pp 42-57
62. Woolverton WL, Johnson KM (1992): Neurobiology of cocaine abuse. Trends Pharmacol Sci 31:193-200
63. Wyatt RJ, Karoum F, Suddath R, Fawcett R (1988): Persistently decreased brain dopamine levels and cocaine. JAMA 27:2996
64. Xia Y, Goebel DJ, Kapatos G, Bannon MJ (1992): Quantitation of rat dopamine transporter mRNA. Effects of cocaine treatment anld withdrawal. J Neurochem 59:1179-1182
65. 3H]dopamine. Neuropharmacology 29:475-486