Hepatocellular carcinoma in patients from northern Sweden with acute intermittent porphyria: Morphology and mutations

Cancer Epidemiology Biomarkers and Prevention

Volumn 5, Issue 5, 1996, Pages 393-397

  Bjersing, Lars ^a,c   Andersson, Christer ^b   Lithner, Folke ^a  

^a UMEÅ UNIVERSITY HOSPITAL   (Sweden)

^b Primary Health Care Centre   (Sweden)

^c UMEÅ UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

AFLATOXIN; PORPHOBILINOGEN DEAMINASE;

ACUTE INTERMITTENT PORPHYRIA; AMINO ACID SUBSTITUTION; ARTICLE; AUTOSOMAL DOMINANT INHERITANCE; CANCER INCIDENCE; DNA DAMAGE; GENE MUTATION; HEPATITIS B VIRUS; HUMAN; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; PRIORITY JOURNAL; SWEDEN; TUMOR SUPPRESSOR GENE;

ADENINE; AGED; AGED, 80 AND OVER; ALLELES; BASE SEQUENCE; CARCINOMA, HEPATOCELLULAR; CELL DIVISION; CODON; DNA DAMAGE; DNA, VIRAL; FEMALE; FIXATIVES; FORMALDEHYDE; GENES, P53; GENES, RAS; GENES, TUMOR SUPPRESSOR; GUANINE; HEME; HEPATITIS B VIRUS; HUMANS; HYDROXYMETHYLBILANE SYNTHASE; LIVER CIRRHOSIS; LIVER NEOPLASMS; MALE; MIDDLE AGED; MUTATION; PORPHYRIA, ACUTE INTERMITTENT; SWEDEN; TISSUE FIXATION;

EID: 0030000436     PISSN: 10559965     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Wetterberg, L. A neuropsychiatric and genetic investigation of acute intermittent porphyria. Stockholm: Svenska Bokförlaget/Norstedts, 1967.
2. Battle, A. M. Porphyrins, porphyrias, cancer and photodynamic therapy-a model for carcinogenesis. J. Photochem. Photobiol. B. Biol., 20: 5-22, 1993.
3. Thunell, S., Andersson, C., Carlmark, B., Floderus, Y., Grönqvist, S. O., Harper, P., Henrichson, A., and Lindh, U. Markers for vulnerability in acute porphyria. A hypothesis paper. Eur. J. Clin. Chem. Clin. Biochem., 33: 179-194, 1995.
4. Kappas, A., Sassa, S., Galbraith, R., and Nordmann, Y. The porphyrias. In: C. L. Scriver, A. I. Beudet, W. S. Sly, and D. Valle (eds.), Metabolic Basis of Inherited Disease, Ed. 6, pp. 1320-1329. New York: McGraw-Hill, 1989.
5. Kauppinen, R., and Mustajoki, P. Prognosis of acute porphyria: occurrence of acute attacks, precipitating factors, and associated diseases. Medicine (Baltimore), 71: 1-13, 1992.
6. Lee, J. S., and Anvret, M. Identification of the most common mutation within the porphobilinogen deaminase gene in Swedish patients with acute intermittent porphyria. Proc. Natl. Acad. Sci. USA, 88: 10912-10915, 1991.
7. Lithner, F., and Wetterberg, L. Hepatocellular carcinoma in patients with acute intermittent porphyria. Acta Med. Scand., 215: 271-274, 1984.
8. Hardell, L., Bengtsson, N. O., Jonsson, U., Eriksson, S., and Larsson, L. G. Aetiological aspects on primary liver cancer with special regard to alcohol, organic solvents and acute intermittent porphyria: an epidemiological investigation. Br. J. Cancer, 50: 389-397, 1984.
9. Kauppinen, R., and Mustajoki, P. Acute hepatic porphyria and hepatocellular carcinoma. Br. J. Cancer, 57: 117-120, 1988.
10. Hsu, I. C., Metcalf, R. A., Sun, T., Welsh, J. A., Wang, N. J., and Harris, C. C. Mutational hotspot in the p53 gene in human hepatocellular carcinomas. Nature (Lond.). 350: 427-428, 1991.
11. Bressac, B., Kew, M., Wands, J., and Ozturk, M. Selective G to T mutations of p53 gene in hepatocellular carcinoma from southern Africa. Nature (Lond.), 550: 429-431, 1991.
12. Diamantis, I. D., McGandy, C., Chen, T-J., Liaw, Y-F., Gudat, F., and Bianchi, L. A new mutational hot-spot in the p53 gene in human hepatocellular carcinoma. J. Hepatol., 20: 553-556, 1994.
13. Culling, C. F. A. Handbook of Histopathological Techniques, Ed. 2, pp. 199-317. London: Butterworths, 1963.
14. Craig, J. R., Peters, R. L., and Edmondson, H. A. Tumors of the liver and intrahepatic bile ducts. In: W. H. Hartmann and L. H. Sobin (eds.), Atlas of Tumor Pathology, Fascicle 26, Series 2. Washington, D. C.: Armed Forces Institute of Pathology, 1989.
15. Scheuer, P. J., Williams, R., and Muir, A. R. Hepatic pathology in relatives of patients with haemochromatosis. J. Pathol. Bacteriol., 84: 53-64, 1962.
16. Kanai, T., Hirohashi, S., Upton, M. P., Noguchi, M., Kishi, K., Makuuchi, M., Yamasaki, S., Hasegawa, H., Takayasu, K., Moriyama, N., and Shimosato, Y. Pathology of small hepatocellular carcinoma. A proposal for a new gross classification. Cancer (Phila.), 60: 810-819, 1987.
17. Bjersing, L., Rogo, K., Evander, M., Gerdes, U., Stendahl, U., and Wadell, G. HPV 18 and cervical adenocarcinomas. Anticancer Res., 11: 123-128, 1991.
18. Erlich, H. A., Gelfand, D., and Sninsky, J. J. Recent advances in the polymerase chain reaction. Science (Washington DC), 252: 1643-1651, 1991.
19. Bjersing, L., Andersson, C., and Lithner, F. Easy detection of mutations in acute intermittent porphyria and hepatocellular carcinoma on paraffin-embedded tissue. J. Intern. Med., 234: 339-340, 1993.
20. Capon, D. J., Chen, E. Y., Levinson, A. D., Seeburg, P. H., and Goeddel, D. V. Complete nucleotide sequences of the T24 human bladder carcinoma oncogene and its normal homologue. Nature (Lond.), 302: 33-37, 1983.
21. Jiang, W., Kahn, S. M., Guillem, J. G., Lu, S-H., and Weinstein, I. B. Rapid detection of ras oncogenes in human tumors: applications to colon, esophageal, and gastric cancer. Oncogene, 4: 923-928, 1989.
22. Gerber, M. A., Shieh, Y. S. C., Shim, K-S., Thung, S. N., Demetris, A. J., Schwartz, M., Akyol, G., and Dash, S. Detection of replicative hepatitis C virus sequences in hepatocellular carcinoma. Am. J. Pathol., 141: 1271-1277, 1992.
23. Gaidano, G., Ballerini, P., Gong, J. Z., Inghirami, G., Neri, A., Newcomb, E. W., Magrath, I. T., Knowles, D. M., and Dalla-Favera, R. p53 mutations in human lymphoid malignancies: association with Burkitt lymphoma and chronic lymphocytic leukemia. Proc. Natl. Acad. Sci. USA, 88: 5413-5417, 1991.
24. Oka, K., Ishikawa, J., Bruner, J. M., Takahashi, R., and Saya, H. Detection of loss of heterozygosity in the p53 gene in renal cell carcinoma and in bladder cancer using the polymerase chain reaction. Mol. Carcinog., 4: 10-13, 1991.
25. Kauppinen, R., Mustajoki, S., Pihlaja, H., Peltonen, L., and Mustajoki, P. Acute intermittent porphyria in Finland: 19 mutations in the porphobilinogen deaminase gene. Hum. Mol. Genet., 4: 215-222, 1995.
26. Ozturk, M. p53 mutation in hepatocellular carcinoma after aflatoxin exposure. Lancet, 338: 1356-1359, 1991.
27. Aguilar, F., Hussain, S. P., and Cerutti, P. Aflatoxin B1 induces the transversion of G to T in codon 249 of the p53 tumor suppressor gene in human hepatocytes. Proc. Natl. Acad. Sci. USA, 90: 8586-8590, 1993.
28. Aguilar, F., Harris, C. C., Sun, T., Hollstein, P., and Cerutti, P. Geographic variation of p53 mutational profile in non-malignant human liver. Science (Washington DC), 264: 1317-1319, 1994.
29. Harris, C. C. p53: At the crossroads of molecular carcinogenesis and risk assessment. Science (Washington DC), 262: 1980-1981, 1993.
30. Greenblatt, M. S., Bennett, W. P., Hollstein, M., and Harris, C. C. Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis. Cancer Res., 54: 4855-4878, 1994.