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Sung JJY, Chung S, Ling TKW, Yee Yung M, Leung VKS, No EKW, Li MKK, Cheng AFB, Li AKC: Antibacterial treatment of gastric ulcers associated with Helicobacter pylori. N Engl J Med 1995, 332:139-143. Impressively good results in healing gastric ulcers were obtained with antibiotic treatment without acid suppression.
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Sung YJ, Leung V, Chung S, Ling TK, Suen R, Cheng AF, Li AK: Triple therapy with sucralfate, tetracycline and metronidazole for Helicobacter pylori-associated duodenal ulcers. Am J Gastroenterol 1995, 90:1424-1427. Sucralfate may be a component of the eradication regimen but bismuth combinations give better results.
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De Boer WA, Driessen WMM, Arjan RJ, Tytgat GNJ: Quadruple therapy compared with dual therapy for eradication of Helicobacter pylori in ulcer patients: results of randomized prospective single-centre study. Eur J Gastroenterol Hepatol 1995, 7:1189-1194. A randomized study showing that quadruple therapy is well tolerated. This therapy is indicated as a second-line treatment for metronidazole-resistant patients.
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0028828333
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Omeprazole enhances efficacy of triple therapy in eradicating Helicobacter pylori
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Borody TJ, Andrews P, Fracchia G, Brandi S, Shortis NP, Bae H: Omeprazole enhances efficacy of triple therapy in eradicating Helicobacter pylori. Gut 1995, 37:477-481. The addition of omeprazole to a bismuth triple therapy enhances enormously the eradication rate.
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Jaup BH, Norrby A: Low dose short term triple therapy for cure of Helicobacter pylori infection and healing of peptic ulcer. Am J Gastroenterol 1995, 90:943-945.
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Yousfy MM, El-Zimaity HMT, AOI-Assi MT, Cole RA, Genta RM, Graham DY: Metronidazole, omeprazole and clarithromycin: an effective combination therapy for Helicobacter pylori infection. Aliment Pharmacol Ther 1995, 9:209-212. This combination has proved to be effective for the eradication of metronidazole-resistant strains.
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Aliment Pharmacol Ther
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Yousfy, M.M.1
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Bell GD, Powell KU, Burridge SM, Bowden AF, Atoyebi W, Bolton GH, Jones PH Browns C: Rapid eradication of Helicobacter pylori infection. Aliment Pharmacol Ther 1995, 9:41-46. In a large number of patients, the results of the triple therapy of omeprazole, amoxycillin and metronidazole, administered at different durations, confirmed the excellent results of the 1-week regimen but with fewer side effects.
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Bell, G.D.1
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Moayyedi P, Sahay P, Tompkins DS, Axon ATR: Efficacy and optimum dose of omeprazole in a new 1-week triple therapy regimen to eradicate Helicobacter pylori. Eur J Gastroenterol Hepatol 1995, 7: 835-840.
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Labenz J, Stolte M, Rurhl G, Becker T, Tillenburg B, Sollbohmer M: One-week low-dose triple therapy for the eradication of Helicobacter pylori infection. Eur J Gastroenterol Hepatol 1995, 7:9-11.
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Goddard A, Logan R: One-week low-dose triple therapy: new standards for Helicobacter pylori treatment. Eur J Gastroenterol Hepatol 1995, 7:1-3. This review provides data indicating that 1 -week duration of the omeprazole triple therapy achieves a very high and constant rate of eradication.
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Yousfy MM, El Zimairy HMT, Cole RA, Genta RM, Graham DY: Metronidazole, ranitidine and clarithromycin in combination treatment of Helicobacter pylori infection (modified Bazzoli's triple therapy). Aliment Pharmacol Ther 1996, 10:119-122.
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Adamek RJ, Opferkuch W, Wegener M: Modified short-term triple therapy - ranitidine, clarithromycin and metronidazole - for cure of Helicobacter pylori infection. Am J Gastroenterol 1995, 90:168-169.
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Laine L, Stein C, Neil G: Limited efficacy of omeprazole-based dual and triple therapy for Helicobacter pylori: a randomized trial employing 'optimal' dosing. Am J Gastroenterol 1995, 90:1407-1410.
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Bertoni G, Sassatelli R, Nigrisoli E, Tansini P, Bianchi G, Della casa G, Bagni A, Bedogni G: Triple therapy with azithromycin, omeprazole and amoxycillin is highly effective in the eradication of Helicobacter pylori: a controlled trial versus omeprazole plus amoxicillin. Am J Gastroenterol 1996, 91:258-263. The randomized comparative study showing that the macrolide, azithromycin, is also very effective in triple therapy to eradicate H. pylori.
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Am J Gastroenterol
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Bertoni, G.1
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Di Mario F, Dal Bó N, Grassi SA, Rugge M, Cassaro M, Donisi PM, Vianello F, Kusstatscher S, Salandin S, Grasso GA et al.: Azithromycin for the cure of Helicobacter pylori infection. Am J Gastroenterol 1996, 91:264-267.
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Am J Gastroenterol
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Changes in the intragastric distribution of Helicobacter pylori during treatment with omeprazole
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Logan RPH, Walker MM, Misiewicz JJ, Gummet PA, Karim QN, Baron JH: Changes in the intragastric distribution of Helicobacter pylori during treatment with omeprazole. Gut 1995, 36:12-16. The potent inhibition by omeprazole of gastric secretion produces changes in the distribution of H. pylori in the gastric mucosa. This fact should be considered in diagnosis.
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Logan, R.P.H.1
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Atrophic gastritis and Helicobacter pylori infection in patients with reflux esophagitis treated with omeprazole or fondoplication
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Kuipers EJ, Lundell L, Klinkenberg-Knol EC, Havu N, Festen H, Liedman B, Lamers C, Jansen JBMJ, Dalenbäck J, Snel P et al.: Atrophic gastritis and Helicobacter pylori infection in patients with reflux esophagitis treated with omeprazole or fondoplication. N Engl J Med 1996, 334: 1018-1022. Patients with reflux oesophagitis and H. pylori infection, who are treated with omeprazole, are at increased risk of atrophic gastritis and should, therefore, be considered for an eradication treatment.
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Kuipers, E.J.1
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A 1-h topical therapy for the treatment of Helicobacter pylori infection
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Kimura K, Kenichi I, Kouji S, Ido K, Saifuku K, Tanigusci Y, Kihira K, Satoh K, Takimoto T, Yoshida Y: A 1-h topical therapy for the treatment of Helicobacter pylori infection. Am J Gastroenterol 1995, 90:60-63. This original method is very effective, although very uncomfortable for the patients. It is unlikely to have a practical application.
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Kimura, K.1
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Double-blind trial of omeprazole and amoxicillin to cure Helicobacter pylori infection in patients with duodenal ulcers
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Bayerdörffer E, Miehlke S, Gerd A, Mannes G, Sommer A, Hochter W, Weingart J, Heldwein W, Klann H, Simon T et al.: Double-blind trial of omeprazole and amoxicillin to cure Helicobacter pylori infection in patients with duodenal ulcers. Gastroenterology 1995, 108:1412-1417. An increase in the eradication rate with high doses of omeprazole was demonstrated. Most authors, however, obtain good results with the standard 40 mg daily dose.
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Bayerdörffer, E.1
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Antibiotic versus maintenance therapy in the prevention of duodenal ulcer recurrence. Results of a multicentric double-blind randomized trial
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Sobhani I, Chastang C, De Korwin JD, Lamouliate H, Mégraud F, Guerre J, Elouaer-Blanc L: Antibiotic versus maintenance therapy in the prevention of duodenal ulcer recurrence. Results of a multicentric double-blind randomized trial. Gastroenterol Clin Biol 1995,19:252-258. A small-scale study demonstrating that the eradication of H. pylori is as effective as maintenance therapy and that it costs less.
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Recrudescence of Helicobacter pylori infection in patients with healed duodenal ulcer after treatment with different regimens
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Xia HX, Gilvarry J, Beattie S, Hamilton H, Keane CT, Eamosn CPI, Sweeney C, O'Morain. C: Recrudescence of Helicobacter pylori infection in patients with healed duodenal ulcer after treatment with different regimens. Am J Gastroenterol 1995, 90:1221-1228. Recrudescence and reinfection are critically analysed after different eradication regimens.
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Lazzaroni M, Maconi G, Bargiggia S, Minguzzi M, Bianchi Porro G: Efficacy of omeprazole combined with antibiotics for Helicobacter pylori eradication and duodenal ulcer recurrence. Eur J Gastroenterol Hepatol 1995, 7:117-119.
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0028926156
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Helicobacter pylori eradication in the African setting, with special reference to reinfection and duodenal ulcer recurrence
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Louw JA, Lucke W, Jaskwicz K, Lastovica AJ, Winter TA, Marks IN: Helicobacter pylori eradication in the African setting, with special reference to reinfection and duodenal ulcer recurrence. Gut, 36:544-547. Consistently low rates of reinfection were found in African communities with a high prevalence of H. pylori infection.
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Recurrence of duodenal ulcers during five years of follow-up after cure of Helicobacter pylori infection
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Miehlke S, Bayerdörffer E, Lehn N, Mannes GA, Höchter W, Weingart J, Sommers A, Heldwein W, Müller-Lissner S, Bästlein E, et al: Recurrence of duodenal ulcers during five years of follow-up after cure of Helicobacter pylori infection. Eur J Gastroenterol Hepatol 1995, 7:975-978. A long follow-up European multicentre study in duodenal ulcer patients after eradication of H. pylori.
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Martin JG, Diament RH, Dixon MF, Axon ATR, Johnston D: Helicobacter pylori and recurrent ulceration after highly selective vagotomy. Eur J Gastroenterol Hepatol 1995, 7:207-209.
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Martin, J.G.1
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Reilly TG, Ayres RCS, Poxon V, Walt RP: Helicobacter pylori eradication in a clinical setting: success rates and the effect on the quality of life in peptic ulcer. Aliment Pharmacol Ther 1995, 9:483-490.
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Graham DY: A reliable cure for Helicobacter pylori infection? Gut 1995, 37:154-156. On the basis of his personal experience, the author comments on a practical way of evaluating anti-H. pylori trials and the most rational approach to making a decision on the choice of drugs and on the duration of the eradication regimen.
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Moshkowitz M, Konikoff FM, Peled Y, Santo M, Bujanover Y, Tiomny E: High Helicobacter pylori numbers are associated with low eradication rate after triple therapy. Gut 1995, 36:845-847. The pre-treatment urease activity assessed by the urea breath test may be an important factor in predicting H. pylori eradication. For potential clinical applications these data warrant further confirmation.
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Atherton JC, Cockayne A, Balsitis M, Kirk GE, Spiller RC: Detection of the intragastric sites at which Helicobacter pylori evades treatment with amoxycillin and cimetidine. Gut 1995, 36:670-674. This study demonstrates that H. pylori may escape from the antrum to the gastric body and fundus after treatment with a non-potent antisecretory drug and an antibiotic.
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