Subcutaneous low-molecular-weight heparin versus standard heparin and the prevention of thromboembolism in medical inpatients

Pathophysiology of Haemostasis and Thrombosis

Volumn 26, Issue 3, 1996, Pages 127-139

  Harenberg, Job ^a   Roebruckf, Peter ^a   Heene, Dieter L ^a   Hcene, D L ^a   Harenberg, J ^a   Schmitz Huebner, U ^b   Heinrich, F ^c   Roebruck, P ^d   Lechner, K ^e   Georgi, M ^a   Habscheid, W ^f   Spengel, F A ^g   Muller Berghaus G ^h   Rasche, H ⁱ   Gasser, Th ^j   Becker, W ^k   Salge, H ^k   Schurfeld C ^k   Heenc, D L ^a   Stehle, G ^a   Huck, K H ^a   Brecht, J ^a   Eyermann, A ^a   Haug, M ^a   Körner, Th ^a   Kruger A ^a   Marquetant, N ^a   Welk, Th ^a   Heinrich, D ^l   Bcllm, M ^c   Hoferth A ^c   Ostendorf, P C ^m   Aumiller, J ^m   Muller Schulz M ^m   Nol zen, H ^b   Rosocha, St ^b   Buttner M ^g   Haschka, C ^g   Stautner Briickmann, C ^g   Stiegler, H ⁿ   Mosavi, S ⁿ   Standi, R ⁿ   Theiss, W ^o   Weibl, P ^o   Lorenz, R ^o   Baum, U ^o   more..

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b General Hospital of Herford   (Germany)

^c General Hospital of Bruchsal   (Germany)

^d University Department of Medical Statistics of Mannheim   (Germany)

^e MEDICAL UNIVERSITY OF VIENNA   (Austria)

^f UNIVERSITY HOSPITAL WÜRZBURG   (Germany)

^g LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^h Department of Thoracic Surgery   (Germany)

ⁱ Central Hospital Bremen Ost   (Germany)

^j UNIVERSITY OF ZURICH   (Switzerland)

^k RUHR UNIVERSITY BOCHUM   (Germany)

^l General Hospital of Wetzlar   (Germany)

^m Allgemeines Krankenhaus Eilbek   (Germany)

ⁿ Munich General Hospital   (Germany)

^o TECHNICAL UNIVERSITY OF MUNICH   (Germany)

more..

Author keywords

Heparin; Low molecular weight heparin; Prophylaxis; Pulmonary embolism; Thrombosis

Indexed keywords

HEPARIN; HEPARIN CALCIUM; LOW MOLECULAR WEIGHT HEPARIN; NADROPARIN;

ADULT; AGED; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; ERYTHEMA; FEMALE; HEMATOMA; HUMAN; LUNG EMBOLISM; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; PRIORITY JOURNAL; PRURITUS; RANDOMIZED CONTROLLED TRIAL; SUBCUTANEOUS DRUG ADMINISTRATION; THROMBOCYTOPENIA; THROMBOEMBOLISM; THROMBOSIS;

AGED; DOUBLE-BLIND METHOD; FOLLOW-UP STUDIES; HEPARIN; HEPARIN, LOW-MOLECULAR-WEIGHT; HOSPITALS; HUMANS; INCIDENCE; INFANT, NEWBORN; INJECTIONS, SUBCUTANEOUS; PROSPECTIVE STUDIES; PULMONARY EMBOLISM; RISK FACTORS; THROMBOPHLEBITIS;

EID: 0029999825     PISSN: 14248832     EISSN: 14248840     Source Type: Journal    
DOI: 10.1159/000217198     Document Type: Article

References (30)

1. THRIFT Consensus Group: Risk of and prophylaxis for venous thromboembolism in hospital patients. BMJ 1992;305:567-573.
2. Gallus AS: Anticoagulants in the prevention of venous thromboembolism. Baillieres Clin Haematol 1990;3:651-684.
3. Warlow CH, Beattie AG, Terey G, Ogston D, Kenmure CF, Douglas AS: A double-blind trial of low doses of subcutaneous heparin in the prevention of deep-vein thrombosis after myocardial infarction. Lancet 1973;ii:934-937.
4. Gallus AS, Hirsh J. Tuttle RJ. Tre-bilcock R, O’Brien SE, Carroll JJ. Minden JH, Hudecki SM: Small subcutaneous doses of heparin in prevention of venous thrombosis. N Engl J Med 1973;288:545-551.
5. Pitt A, Anderson ST. Habersberger PG. Rosengarten DS: Low dose heparin in the prevention of deep vein thrombosis in patients with acute myocardial infarction. Am Heart J 1980;99:574-578.
6. Emerson PA, Mark SP: Preventing thromboembolism after myocardial infarction-Effect of low dose heparin or smoking. BMJ 1977;264:18-20.
7. McCarthy ST, Turner JJ. Robertson D, Hawkey CJ: Low-dose heparin as a prophylaxis against deep-vein thrombosis after acute stroke. Lancet 1977;i:800-801.
8. McCarthy ST, Turner J: Low-dose subcutaneous heparin in the prevention of deep-vein thrombosis and pulmonary emboli following acute stroke. Age Ageing 1986; 15: 84-88.
9. Czechanowski B, Heinrich F: Prophylaxe venöser Thrombosen bei frischem ischämischem zerebrovas-kulärem Insult. Dtsch Med Wo-chenschr 1981;39:1254-1260.
10. Sandercock PAG, van den Belt AGM, Lindley RI, Slattery J: Anticoagulant and antiplatelet therapy in acute stroke: An overview of the completed randomized trials. J Neurol Ncurosurg Psychiatry 1993;56: 17-25.
11. Barrowcliffe TW, Johnson EA, Eg-gleton CA, Thomas DP: Anticoagulant activities of lung and mucous heparins. Thromb Res 1977:12:27-36.
12. Holmer E. Kurachi K, Söderström G: The molecular-weight dependence of the rate-enhancing effect of heparin on the inhibition of thrombin. factor Xa, factor IXa, factor Xlla and kallikrein by antithrombin. Biochem J 1981;193:395-400.
13. Hirsh J. Levine MN: Low-molecular weight heparin. Blood 1992;79:1-17.
14. Harenberg J. Stehle G, Augustin J. Zimmermann R: Comparative human pharmacology of low molecular weight heparins. Semin Thromb He-most 1989:15:414-423.
15. Holmer E, Mattsson C, Nilsson S: Anticoagulant and antithrombotic effects of heparin and low dose heparin fragments in rabbits. Thromb Res 1982;25:475-485.
16. Carter CJ. Kclton JG, Hirsh J. Cers-kus A, Santos AV. Gent M: The relationship between the hemorrhagic and antithrombotic properties of low molecular weight heparin in rabbits. Blood 1982;59:1239-1245.
17. Kakkar VV, Cohen A, Edmonson RA, Phillips MJ. Cooper DJ. Das SK, Maher KT, Sanderson RM, Ward VP, Kakkar S: Low molecular weight versus standard heparin for prevention of venous thromboembolism after major abdominal surgery. Lancet 1993;341:259-265.
18. Nurmohamed MT, Rosendaal FR. Biiller HR, Dekker E, Hommes DW, Vandenbroucke JP. Briet E: Low-molecular-weight heparin versus standard heparin in general and orthopedic surgery: A meta-analysis. Lancet 1992;340:152-156.
19. Dahan R, Houlbcrt D, Caulin C, Viltart C, Woler M, Segrestaa J: Prevention of deep vein thrombosis in elderly medical inpatients by a low molecular weight heparin: A randomized double-blind trial. Haemostasis 1986; 16:159-164.
20. Harenberg J. Kallenbach B, Martin U, Dempfle CE, Zimmermann R, Kübler W, Heene DL: Randomized controlled study of heparin and low molecular weight heparin for prevention of deep-vein thrombosis in medical patients. Thromb Res 1990; 59:639-650.
21. Prins MH, Gelsema R, Sing AK, van Heerala LR, Ottolander GJH: Prophylaxis of deep vein thrombosis with a low-molecular-weight heparin (Kabi 2165/Fragmin) in stroke patients. Haemostasis 1989; 19:245-250.
22. Turpie AGG, Gent M, Gote R, Levine MN, Ginsberg JS, Powers PJ. Lcclcrs J. Geerts W, Jay R, Neemeh J. Klimek M, Hirsh J: A low-molec-ular-weight heparinoid compared with unfractionated heparin in the prevention of deep vein thrombosis in patients with acute ischemic stroke. Ann Intern Med 1992; 117: 353-357.
23. Harenberg J. Roebruck P, Stehle G, Habscheid W, Biegholdt M, Heene DL, the HESIM Group: Heparin Study in Internal Medicine (HESIM): Design and preliminary results. Thromb Res 1992:68:33-43.
24. PIOPED Investigators: Value of the ventilation/perfusion scan in acute pulmonary embolism. JAMA 1990; 263:2753-2759.
25. Farrington CP: Test statistics and sample size formulate for comparative binomial trials with null hypothesis of non-zero risk difference or non-unity relative risk. Stat Med 1990;9:1447-1454.
26. Armitage P, Berry G: Statistical Methods in Medical Research, ed 2. Oxford, Blackwall Scientific Publications, 1988.
27. Wells PS. Lensing AWA, Davidson BL, Prins MH, Hirsh J: Accuracy of ultrasound for diagnosis of deep venous thrombosis in asymptomatic patients after orthopedic surgery. Ann Intern Med 1995;122:47-53.
28. Wyshock E, Caldwell M, Crowley JP: Deep venous thrombosis, inflammatory bowel disease, and protein S deficiency. Am J Clin Pathol 1988;90:633-635.
29. Coon WW: Risk factors in pulmonary embolism. Surg Gynecol Ob-stet 1976; 143:385-391.
30. Hull R, Raskob G, Pineo G, Rosen-bloom D, Evans W, Mallory T, An-quist K. Smith F, Huges G, Green D, Elliot CG, Panju A, Brant R: A comparison of subcutaneous low-molecular-weight heparin with warfarin sodium for prophylaxis against deep-vein thrombosis after hip or knee implantation. N Engl J Med 1993;329:1370-1376.