Chronic desensitization of the glucose-dependent insulinotropic polypeptide receptor in diabetic rats

American Journal of Physiology - Endocrinology and Metabolism

Volumn 270, Issue 4 33-4, 1996, Pages

  Tseng, Chi Chuan ^a   Boylan, Michael O ^b   Jarboe, Linda A ^b   Usdin, Ted B ^b   Michael Wolfe, M ^b  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b NONE

Author keywords

downregulation; non insulin dependent diabetes mellitus

Indexed keywords

COMPLEMENTARY DNA; CYCLIC AMP; FORSKOLIN; GASTRIC INHIBITORY POLYPEPTIDE; INSULIN; INSULIN RECEPTOR; MESSENGER RNA; PROSTAGLANDIN E1; STREPTOZOCIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DNA TRANSFECTION; DUODENUM MUCOSA; GENE EXPRESSION; INSULIN BLOOD LEVEL; INSULIN LIKE ACTIVITY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR DOWN REGULATION; STREPTOZOCIN DIABETES;

EID: 0029999078     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.1996.270.4.e661     Document Type: Article

References (30)

1. Alam, M. J., J. I. Kerr, K. Cormican, and K. D. Buchanan. Gastric inhibitory polypeptide response in diabetes using a highly specific antiserum. Diabetic Med. 9: 542-545, 1992.
2. Andersen, D. K., D. Elahi, J. C. Brown, J. D. Tobin, and R. Andres. Oral glucose augmentation of insulin secretion: interactions of gastric inhibitory polypoptide with ambient glucose and insulin levels. J. Clin. Invest. 62: 152-161, 1980.
3. Bailey, C. J., P. R. Flatt, P. Kwasowski, and M. Adams. Gastric inhibitory polypeptide and the entero-insular axis in streptozotocin diabetic mice. Diabete Metab. 12: 351-354, 1986.
4. Benovic, J. L., M. Bouvier, M. G. Caron, and R. J. Lefkowitz. Regulation of adenylyl cyclase-coupled β-adrenergic receptors. Annu. Rev. Cell. Biol. 4: 405-428, 1988.
5. Bloom, S. R. GIP in diabetes. Diabetologia 11: 334, 1975.
6. Brown, J. C., and R. A. Pederson. A multiparameter study on the action of preparations containing cholecystokinin-pancreozymin. Scand. J. Gastroenterol. 5: 537-541, 1970.
7. 1 to putative receptors linked to adenylate cyclase of cultured cell lines. J. Biol. Chem. 251: 3037-3044, 1976.
8. Bryer-Ash, M., A. Cheung, and R. A. Pederson. Feedback regulation of glucose-dependent insulinotropic polypeptide secretion by insulin in conscious rats. Regul. Pept. 51: 101-109, 1994.
9. Cataland, S., S. E. Crockett, and J. C. Brown. GIP: its physiologic role and insulinotropic action in dog. Diabetes 24: 1050-1056, 1975.
10. Chomczynski, P., and N. Sacchi. Single-step method of mRNA isolation by guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162: 156-159, 1987.
11. Creutzfeldt, W., M. Talaulicar, R. Ebert, and B. Willms. Inhibition of gastric inhibitory polypeptide release by insulin and glucose in juvenile diabetes. Diabetes 29: 140-145, 1980.
12. Dupré, J., S. A. Watson, and J. C. Brown. Stimulation of insulin secretion by GIP in man. J. Clin. Eridocrinol. Metab. 37: 826-828, 1973.
13. Ebert, R., and W. Creutzfeldt. Hypo- and hypersecretion of GIP in maturity-onset diabetics. Diabetologia 19: 271-272, 1980.
14. Elahi, D., D. K. Anderson, and J. C. Brown, H. T. Debas, R. J. Hershcopf, G. S. Raizes, J. D. Tobin, and R. Andres. Pancreatic α- and β-cell responses to GIP infusion in normal man. Am. J. Physiol. 237 (Endocrinol. Metab. Gastrointest. Physiol. 6): E185-E191, 1979.
15. Elahi, D., M. McAloom-Dyke, N. K. Fukagawa, G. S. Meneilly, A. L. Sclater, K. L. Minaker, J. F. Habener, and D. K. Andersen. The insulinotropic actions of glucose-dependent insulinotropic peptide and glucagon-like peptide-1 in normal and diabetic subjects. Regul. Pept. 51: 63-74, 1994.
16. Fehmann, H. C., and J. F. Habener. Homologous desensitization of the insulinotropic glucagon-like peptide-1 receptor on insulinoma cells. Endocrinology 128: 2880-2888, 1991.
17. Ikeda, T., H. Ochi, I. Ohtani, K. Fujiyama, T. Hoshino, T. Tanaka, T. Takendi, and H. Mashiha. Possible role of the adrenergic mechanism in GIP and GLP-1-induced insulin release in rat. Metab. Clin. Exp. 42: 209-213, 1993.
18. Krarup, T., S. Madsbad, A. Moody, L. Regeur, O. Faber, J. Holst, and L. Sestoft. Diminished immunoreactive gastric inhibitory polypeptide response to a meal in newly diagnosed type I diabetics. J. Clin. Endocrinol. Metab. 56: 1306-1312, 1983.
19. May, J. M., and R. H. Williams. The effect of endogenous gastric inhibitory polypeptide on glucose induced insulin secretion in mild diabetes. Diabetes 27: 829-855, 1978.
20. Mayor, F., J. L. Benovic, M. G. Caron, and R. J. Lefkowitz. Somatostatin induces translocation of the β-adrenergic receptor kinase and desensitizes somatostatin receptors in S49 lymphoma cells. J. Biol. Chem. 262: 6468-6471, 1987.
21. Murphy, G. J., V. J. Hruby, D. Trivedi, J. O. Wakelam, and M. D. Houslay. The rapid desensitization of glucagon-stimulated adenylate cyclase is a cyclic AMP-independent process that can be mimicked by hormones which stimulate inositol phospholipid metabolism. Biochem. J. 243: 39-46, 1987.
22. Nauck, M. A., M. M. Heimesaat, C. Orskov, J. Holst, R. Ebert, and W. Creutzfeldt. Preserved incretin activity of glucagon-like peptide I but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitus. J. Clin. Invest. 91: 301-307, 1993.
23. Pederson, R. A., H. E. Schubert, and J. C. Brown. Gastric inhibitory polypeptide, its physiologic release and insulinotropic action in the dog. Diabetes 24: 1050-1056, 1975.
24. Robberecht, P., P. De Neef, M. Waelbroeck, M. Tastenoy, and L. Christophe. VIP and related peptides induced rapid homologous desensitization in the human lymphoma SUP T1 cell line. Peptides 10: 441-446, 1989.
25. Schulz, T. B., R. Jorde, and P. G. Burhol. Fasting portal vein plasma levels of gastric inhibitory polypeptide and extractable fasting GIP in the duodenal wall in rats treated with methylprednisolone or alloxan compared with normal controls. Scand. J. Gastroenterol. 17: 487-490, 1982.
26. Tseng, C.-C., L. A. Jarboe, and M. M. Wolfe. Regulation of glucose-dependent insulinotropic peptide gene expression by a glucose meal. Am. J. Physiol. 266 (Gastrointest. Liver Physiol. 29): G887-G891, 1994.
27. Usdin, T. B., E. Mezey, D. C. Button, M. J. Brownstein, and T. I. Bonner. Gastric inhibitory polypeptide receptor, a member of the secretin-vasoactive intestinal peptide receptor family, is widely distributed in peripheral organs and the brain. Endocrinology 133: 2861-2870, 1993.
28. Verdonk, C. A., R. A. Rizza, R. L. Nelson, V. L. W. Go, and J. E. Gerich. Interaction of fat-stimulated gastric inhibitory polypeptide on pancreatic alpha and beta cell function. J. Clin. Invest. 65: 1119-1125, 1980.
29. Winsett, O. E., C. M. Townsend, Jr., and J. C. Thompson. Rapid and repeated blood sampling in the conscious laboratory rat: a new technique. Am. J. Physiol. 249 (Gastrointest. Liver Physiol. 12): G145-G146, 1985.
30. Xu, Z.-X., and S. Melethil. Simultaneous sampling of blood, bile, and urine in rats for pharmacokinetic studies. J. Pharmacol. Methods 24: 203-208, 1990.