Role of interleukin 6 in epithelial hyperproliferation and bone resorption in middle ear cholesteatomas

European Archives of Oto-Rhino-Laryngology

Volumn 253, Issue 3, 1996, Pages 152-157

  Bujia J ^a   Kim, C ^a   Ostos, P ^b   Kastenbauer, E ^a   Hultner L ^c  

^a UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY OF CÓRDOBA   (Spain)

^c INSTITUTE OF EPIDEMIOLOGY   (Germany)

Author keywords

Bioassay; Cholesteatoma; Enzyme linked immunosorbent assay; Interleukin 6

Indexed keywords

ALKALINE PHOSPHATASE; CYTOKINE; INTERLEUKIN 6; INTERLEUKIN 6 ANTIBODY; PROTEIN;

ANIMAL CELL; ARTICLE; CELL LINE; CELL PROLIFERATION; CHOLESTEATOMA; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; EPIDERMIS; EPITHELIUM CELL; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MIDDLE EAR; MOUSE; NONHUMAN; OSTEOLYSIS; PRIORITY JOURNAL; STAINING; TISSUE DISTRIBUTION;

BONE RESORPTION; CELL MOVEMENT; CHOLESTEATOMA; EAR, MIDDLE; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITHELIUM; HUMANS; IMMUNOHISTOCHEMISTRY; INTERLEUKIN-6;

EID: 0029998884     PISSN: 09374477     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF00615113     Document Type: Article

References (34)

1. Aarden LA, De Groot ER, Schaap OL, Lansdorp PM (1987) Production of hybridoma growth factor by human monocytes. Eur J Immunol 17:1411-1416
2. Ahn JM, Huang CC, Abramson M (1990) Interleukin-1 causing hone destruction in middle ear cholesteatoma. Otolaryngol Head Neck Surg 103:527-36
3. Black K, Garret IR, Mundy GR (1991) Chinese hamster ovarian cells transfected with the murine interleukin 6 gene cause hypercalcemia as well as cachexia, leukocytosis and thrombocytosis in tumor-bearing nude mice. Endocrinology 128:2657-2659
4. Boxman I, Löwick C, Aarden L, Ponec M (1993) Modulation of IL-6 production and IL-1 activity by keratinocyte-fibroblast interaction. J Invest Dermatol 101:316-324
5. Bujía J, Holly A, Kim C, Schilling V, Kastenbauer E (1993) Neue Aspekte zur Pathogenese des Cholesteatoms: die mögliche Rolle einer durch Immunzellen induzierten Keratinozyten-Hyperproliferation. Laryngorhinootologie 72:247-283
6. Bujía J, Holly A, Schilling V, Negri B, Pitzke P, Schulz P (1993) Aberrant expression of epidermal growth factor receptor in aural cholesteatoma. Laryngoscope 103:326-329
7. Bujía J, Schilling V, Holly A, Stammberger M, Kastenbauer E (1993) Hyperproliferation-associated keratin expression in human middle ear cholesteatoma. Acta Otolaryngol (Stockh) 113: 364-368
8. Content J, De Witt L, Poupart P, Opdenakker G, Van Damme J, Billiau A (1985) Induction of a 2-kDa-protein mRNA in human cells treated with an interleukin 1-related, leukocyte-derived factor. Eur J Biochem 152:253-258
9. Frei K, Leist TP, Meager A, Gallo P, Leppert D, Zinkernagel RM, Fontana A (1988) Production of B cell stimulatory factor-2 and interferon gamma in the central nervous system during viral meningitis and encephalitis. J Exp Med 168:449-453
10. Helle M, Boije L, Aarden LA (1988) Functional discrimination between interleukin 6 and interleukin 1. Eur J Immunol 18: 1535-1540
11. Hirano T, Akira S, Taga T, Kishimoto T (1990) Biological and clinical aspects of inteleukin-6. Immunol Today 11:443-449
12. Huang T, Yan SD, Huang CC (1989) Colony-stimulating factor in middle ear cholesteatoma. Am J Otolaryngol 10:393-398
13. Hültner L, Moeller J (1990) Mast cell growth-enhancing activity (MEA) stimulates interleukin 6 production in a mouse bone marrow-derived mast cell line and a malignant subline. Exp Hematol 18:873-887
14. Ishimi Y, Miyaura C, Kin CH, Akatsu T, Abe T, Nakamura Y, Yamaguchi A, Yoshiki S, Matsuda T, Hirano T, Kishimoto T, Suda T (1990) IL-6 is produced by osteoblasts and induces bone resorption. J Immunol 145:3297-3303
15. Kohase M, Henriksen D, May LT, Vilcek J, Sehgal PB (1986) Induction of beta 2 interferon by tumor necrosis factor: a homeostatic mechanism in the control of cell proliferation. Cell 45:659-662
16. Matsuda T, Hirano T, Kishimoto T (1988) Establishment of an interleukin 6 (IL6)/B cell stimulatory factor 2-dependent cell line and preparation of anti-IL-6 monoclonal antibodies. Eur J Immunol 18:951-995.
17. May LT, Helfgott DC, Sehgal PB (1986) Anti-beta-interferon antibodies inhibit the increased expression of HLA-B7 mRNA in tumor necrosis factor-treated human fibroblasts: structural studies of the beta 2 interferon involved. Proc Natl Acad Sci USA 83:8957-8961
18. Mosmann T (1983) Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 65:55-60
19. Mundy GR (1993) Role of cytokines in bone resorption. J Cell Biochem 53:296-300
20. Palva T (1990) The pathogenesis and treatment of cholesteatoma. Acta Otolaryngol (Stockh) 109:323-330
21. Prens EP, Benne K, Van Damme J, Bakkus M, Brakel K, Benner R, Van Joost T (1990) Interleukin-1 and interleukin-6 in psoriasis. J Invest Dermatol 95:121S-124S
22. Roodman GD, Kurihara N, Ohsaki Y, Kukita T, Hosking D, Demulder A, Singer FR (1991) Interleukin 6: a potential autocrine paracrine factor in Paget's disease of bone. J Clin Invest 89:46-52
23. Schilling V, Negri B, Bujia J, Schulz P, Kastenbauer E (1992) Possible role of interleukin 1 alpha and interleukin 1 beta in the pathogenesis of cholesteatoma of the middle ear. Am J Otol 13:350-355
24. Schulz P, Bujia J, Holly A, Schilling V, Kastenbauer E (1993) Possible autocrine growth stimulation of cholesteatoma epithelium by transforming growth factor alpha. Am J Otolaryngol 14:82-87
25. Seghal PB (1990) Interleukin-6: molecular pathophysiology. J Invest Dermatol 94:2S-6S
26. Van Damme J, Opdenakker G, Simpson RJ, Rubira MR, Cayphas S, Vink A, Billiau A, Van Snick J (1987) Identification of the human 26-kD protein interferon beta 2 as a B cell hybridoma (plasmacytoma) growth factor induced by interleukin 1 and tumor necrosis factor. J Exp Med 165:914-920
27. Van Snick K (1990) Interleukin-6: an overview. Annu Rev Immunol 8:253-278
28. 2-terminal amino acid sequence of a T-cell-derived lymphokine with growth factor activity for B-cell hybridomas. Proc Natl Acad Sci USA 83:9679-9683
29. Vink A; Coulie PG, Wauters P, Nordan RP, Van Snick K (1988) B cell growth and differentiation activity of interleukin-HP1 and related murine planacytoma growth factors. Synergy with interleukin 1. Eur J Immunol 18:607-610
30. Wong GG, Clark SC (1988) Multiple actions of interleukin 6 within cytokine network. Immunol Today 9:137-141
31. Yan SD, Huang CC (1991) Tumor necrosis factor alpha in middle ear cholesteatoma and its effect on keratinocytes in vitro. Ann Otol Rhinol Laryngol 100:157-161
32. Yan SD, Huang CC (1991) Lymphotoxin in human middle ear cholesteatoma. Laryngoscope 101:411-415
33. Yellon RF, Leonard G, Marucha P, Sidman J, Carpenter R, Burleson J, Carlson J, Kreutzer D (1992) Demonstration of interleukin 6 in middle ear effusions. Arch Otolarygnol Head Neck Surg 118:745-748
34. Yoshizaki K, Nishimoto N, Matsumoto K, Tagoh H, Taga T, Deguchi Y, Kuritani T, Hirano T, Hashimoto K, Okada N, Kishimoto T (1990) Interleukin 6 and expression of its receptor on epidermal keratinocytes. Cytokine 2:381-387