Hyperglycaemia affects proximal gastric motor and sensory function in normal subjects

European Journal of Gastroenterology and Hepatology

Volumn 8, Issue 3, 1996, Pages 211-217

  Hebbard, Geoffrey S ^a   Sun, Wei Ming ^a   Dent, John ^a   Horowitz, Michael ^a,b  

^a UNIVERSITY OF ADELAIDE   (Australia)

^b ROYAL ADELAIDE HOSPITAL   (Australia)

Author keywords

Gastric emptying; Gastric fundus; Hyperglycaemia; Sensation

Indexed keywords

ABDOMINAL DISCOMFORT; ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIABETES MELLITUS; ELASTICITY; HUMAN; HUMAN EXPERIMENT; HUNGER; HYPERGLYCEMIA; MALE; MOTOR PERFORMANCE; NAUSEA; NORMAL HUMAN; PERCEPTION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SENSATION; SENSORY NERVE; SMOOTH MUSCLE TONE; STOMACH DISTENSION; STOMACH EMPTYING; STOMACH FUNCTION; STOMACH PRESSURE;

EID: 0029998729     PISSN: 0954691X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00042737-199603000-00005     Document Type: Article

References (61)

1. MacGregor IL, Gueller R, Watts HD, Meyer JH: The effect of acute hyperglycemia on gastric emptying in man. Gastroenterology 1976, 70:190-196.
2. Fraser RJ, Horowitz M, Maddox AF, Harding PE, Chatterton BE, Dent J: Hyperglycaemia slows gastric emptying in type 1 (insulin-dependent) diabetes mellitus. Diabetologia 1990, 33:675-680.
3. Fraser R, Horowitz M, Dent J: Hyperglycaemia stimulates pyloric motility in normal subjects. Gut 1991, 32:475-478.
4. Barnett JL, Owyang C: Serum glucose concentration as a modulator of interdigestive gastric motility. Gastroenterology 1988, 94:739-744.
5. Horowitz M, Edelbroek MA, Wishart JM, Straathof JW: Relationship between oral glucose tolerance and gastric emptying in normal healthy subjects. Diabetologia 1993, 36:857-862.
6. Schvarcz E, Palmer M, Aman J, Lindkvist B, Beckman KW: Hypoglycaemia increases the gastric emptying rate in patients with type 1 diabetes mellitus. Diabet Med 1993, 10:660-663.
7. Horowitz M, Fraser R: Disordered gastric motor function in diabetes mellitus. Diabetologia 1994, 37:543-551.
8. Horowitz M, Dent J: Disordered gastric emptying: mechanical basis, assessment and treatment. Baillières Clin Gastroenterol 1991, 5:371-407.
9. Kelly KA: Gastric emptying of liquids and solids: roles of proximal and distal stomach. Am J Physiol 1980, 239:G71-G76.
10. Horowitz M, Dent J: The study of gastric mechanics and flow: A mad hatter's tea party starting to make sense? Gastroenterology 1994, 107:302-306.
11. Oliveira RB, Troncon LE, Meneghelli UG, Dantas RO, Godoy RA: Gastric accommodation to distension and early gastric emptying in diabetics with neuropathy. Braz J Med Biol Res 1984, 17:49-53.
12. Horowitz M, Edelbroek M, Fraser R, Maddox A, Wishart J: Disordered gastric motor function in diabetes mellitus. Recent insights into prevalence, pathophysiology, clinical relevance, and treatment. Scand J Gastroenterol 1991, 26:673-684.
13. Urbain JL, Vekemans MC, Bouillon R, Van-Cauteren J, Bex M, Mayeur SM, et al.: Characterization of gastric antral motility disturbances in diabetes using a scintigraphic technique. J Nucl Med 1993, 34:576-581.
14. Azpiroz F, Malagelada JR: Physiological variations in canine gastric tone measured by an electronic barostat. Am J Physiol 1985, 248:G229-G237.
15. Mearin F, Cucala M, Azpiroz F, Malagelada JR: The origin of symptoms on the brain-gut axis in functional dyspepsia. Gastroenterology 1991, 101:999-1006.
16. Moragas G, Azpiroz F, Pavia J, Malagelada JR: Relations among intragastric pressure, postcibal perception, and gastric emptying. Am J Physiol 1993, 264:G1112-G1117.
17. Horowitz M, Harding PE, Maddox AF, Wishart JM, Akkermans LM, Chatterton BE, et al.: Gastric and oesophageal emptying in patients with type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia 1989, 32:151-159.
18. Lemann M, Dederding JP, Flourie B, Franchisseur C, Rambaud JC, Jian R: Abnormal perception of visceral pain in response to gastric distension in chronic idiopathic dyspepsia. The irritable stomach syndrome. Dig Dis Sci 1991, 36:1249-1254.
19. Morley G, Mooradian A, Levine A, Morley J: Mechanism of pain in diabetic peripheral neuropathy. Am J Med 1984, 77:79-82.
20. Westerman RA, Delaney C, Ivamy Phillips A, Horowitz M, Roberts A: Concordance between different measures of small sensory and autonomic fibre neuropathy in diabetes mellitus. Clin Exp Neurol 1989, 26:51-63.
21. Ewing D, Clarke B: Diagnosis and management of diabetic autonomic neuropathy. Br Med J 1982, 285:916-918.
22. Zeger SL, Liang KY: Longitudinal data analysis for discrete and continuous outcomes. Biometrics 1986, 42:121-130.
23. Heddle R, Dent J, Read NW, Houghton LA, Toouli J, Horowitz M, et al.: Antropyloroduodenal motor responses to intraduodenal lipid infusion in healthy volunteers. Am J Physiol 1988, 254:G671-G679.
24. Azpiroz F, Malagelada JR: Intestinal control of gastric tone. Am J Physiol 1985, 249:G501-G509.
25. Azpiroz F, Malagelada JR: Vagally mediated gastric relaxation induced by intestinal nutrients in the dog. Am J Physiol 1986, 251:G727-G735.
26. Edelbroek M, Horowitz M, Dent J, Sun WM, Malbert C, Smout A, et al.: Effects of duodenal distension on fasting and post-prandial antropyloroduodenal motility in humans. Gastroenterology 1994, 106:583-592.
27. Azpiroz F, Malagelada JR: Perception and reflex relaxation of the stomach in response to gut distention. Gastroenterology 1990, 98:1193-1198.
28. Fone DR, Horowitz M, Maddox A, Akkermans LM, Read NW, Dent J: Gastroduodenal motility during the delayed gastric emptying induced by cold stress. Gastroenterology 1990, 98:1155-1161.
29. de-Boer SY, Masclee AA, Lam WF, Lamers CB: Effect of acute hyperglycemia on esophageal motility and lower esophageal sphincter pressure in humans. Gastroenterology 1992, 103:775-780.
30. de-Boer SY, Masclee AA, Iam WF, Schipper J, Jansen JB, Lamers CB: Hyperglycemia modulates gallbladder motility and small intestinal transit time in man. Dig Dis Sci 1993, 38:2228-2235.
31. de-Boer SY, Masclee AA, Lam WF, Schipper J, Jansen JB, Lamers CB: Hyperglycemia reduces gallbladder emptying and plasma hormone secretion to modified sham feeding and regular feeding. Hepatology 1993, 17:1022-1027.
32. Sims M, Hasler W, Chey W, Kim M, Owyang C: Hyperglycemia inhibits mechanoreceptor-mediated gastrocolonic responses and colonic peristaltic reflexes in healthy humans. Gastroenterology 1994, 108:350-359.
33. Oster Jorgensen E, Pedersen SA, Larsen ML: The influence of induced hyperglycaemia on gastric emptying rate in healthy humans. Scand J Clin Lab Invest 1990, 50:831-836.
34. Jebbink R, Samsom M, Bruijs P, Bravenboer B, Akkermans L, Vanberge-Henegouwen G, et al.: Hyperglycemia induces abnormalities of gastric myoelectrical activity in patients with type 1 diabetes mellitus. Gastroenterology 1994, 107:1390-1397.
35. Sakaguchi T, Ohtake M, Yamazaki M: D-glucose anomers in the nucleus of the vagus nerve can depress gastric motility of rats. Brain Res 1985, 332:390-393.
36. Sakaguchi T, Aono T, Ohtake M, Sandoh N: Interaction of glucose signals between the nucleus of the vagus nerve and the portal vein area in the regulation of gastric motility in rats. Brain Res Bull 1994, 33:469-471.
37. Sakaguchi T, Shimojo E: Inhibition of gastric motility induced by hepatic portal injections of D-glucose and its anomers. J Physiol (Lond) 1984, 351:573-581.
38. Azpiroz F, Malagelada JR: Importance of vagal input in maintaining gastric tone in the dog. J Physiol (Lond) 1987, 384:511-524.
39. Ohta T, Ito S, Ohga A: Co-release of PHI and VIP in dog stomach by peripheral and central vagal stimulation. Br J Pharmacol 1990, 100:231-236.
40. Reid AM, Shulkes A, Titchen DA: Effects of the vagus nerves on gastric motility and release of vasoactive intestinal polypeptide in the anaesthetized lamb. J Physiol (Lond) 1988, 396:11-24.
41. Toma TP, Thompson DG, Troncon L, Ahuwalia NK: Effect of glyceryl trinitrate on proximal stomach musculature in normal volunteers. Rev Med Chir Soc Med Nat Iasi 1992, 96:5-9.
42. Carvajal S, Mulvihill S: Gastric accommodation is mediated by both VIP and nitric oxide in the rat. Gastroenterology 1994, 106:A474
43. Baccari MC, Calamai F, Staderini G: Non-adrenergic, non-cholinergic influences on rabbit gastric tone. Funct Neurol 1990, 5:197-199.
44. Baccari MC, Calamai F, Staderini G: Vagally-induced non-adrenergic, non-cholinergic inhibitory motility in the rabbit stomach in vivo. Funct Neurol 1991, 6:239-242.
45. Hilsted I: Pathophysiology in diabetic autonomic neuropathy: cardiovascular, hormonal and metabolic studies. Diabetes 1982, 31:730-737.
46. Eliasson B, Bjornsson E, Urbanavicius V, Andersson H, Fowlein J, Attvall S, et al.: Hyperinsulinemia impairs gastrointestinal motility and slows carbohydrate absorption. Diabetologia 1995, 38:79-85.
47. Ziegler D, Mayer P, Cries FA: Evaluation of thermal, pain, and vibration sensation thresholds in newly diagnosed type 1 diabetic patients. J Neurol Neurosurg Psychiat 1988, 51:1420-1424.
48. Gonder-Frederick LA, Cox DJ, Bobbin SA, Pennebaker JW: Mood changes associated with blood glucose fluctuations in insulin-dependent diabetes mellitus. Health Psychol 1989, 8:45-59
49. Thye-Ronn P, Sindrup SH, Arendt-Nielsen L, Brennum J, Hother-Nielsen O, Beck-Nielsen H: Effect of short-term hyperglycemia per se on nociceptive and non-nociceptive thresholds. Pain 1994, 56:43-49.
50. Raz I, Hasdai D, Seltzer Z, Melmed RN: Effect of hyperglycemia on pain perception and on efficacy of morphine analgesia in rats. Diabetes 1988, 37:1253-1259.
51. Chan AW, MacFarlane IA, Bowsher D: Short term fluctuations in blood glucose concentrations do not alter pain perception in diabetic-patients with and without painful peripheral neuropathy. Diabetes Res 1990, 14:15-19.
52. Thompson DG: Modulation of gastric perception and motility in man. Current concepts and correlation with symptoms. Dig Dis Sci 1994, 39:48s-50s.
53. Blackshaw LA, Grundy D, Scratcherd T: Vagal afferent discharge from gastric mechanoreceptors during contraction and relaxation of the ferret corpus. J Autonom Nerv Syst 1987, 18:19-24.
54. Notivol R, Coffin B, Azpiroz F, Mearin F, Serra J, Malagelada J: Gastric tone determines the sensitivity of the stomach to distention. Gastroenterology 1995, 108:330-336.
55. Blackshaw LA, Grundy D: Effects of 5-hydroxylryptamine (5-HT) on the discharge of vagal mechanoreceptors and motility in the upper gastrointestinal tract of the ferret. J Auton Nerv Syst 1993, 45:51-59.
56. Cottrell D, Iggo A: The responses of duodenal tension receptors in sheep to pentagastrin, cholecystokinin and some other drugs. J Physiol 1984, 354:477-495.
57. Davison JS, Clarke CD: Mechanical properties and sensitivity to CCK of vagal gastric slowly adapting mechanoreceptors. Am J Physiol 1988, 255:G55-G61.
58. Ropert A, des-Varannes SB, Bizais Y, Roze C, Galmiche JP: Simultaneous assessment of liquid emptying and proximal gastric tone in humans. Gastroenterology 1993, 105:667-674.
59. Barbera R, Feinle C, Read N: Nutrient-specific modulation of gastric mechanosensitivity in patients with functional dyspepsia. Gastroenterology 1994, 106:A463.
60. Feinle C, Grundy D, Read NW: Effects of isocaloric duodenal carbohydrate and lipid on gastric motor and sensory responses to gastric distension. Gastroenterology 1995, 4:A597.
61. MacGregor IL, Deveney C, Way LW, Meyer JH: The effect of acute hyperglycemia on meal-stimulated gastric, biliary, and pancreatic secretion, and serum gastrin. Gastroenterology 1976, 70:197-202.