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Volumn 258, Issue 2, 1996, Pages 308-321

Structure of a hexanucleotide RNA hairpin loop conserved in ribosomal RNAs

Author keywords

G B pair; Large subunit ribosomal RNA; Thiostrepton resistance; U turn

Indexed keywords

RIBOSOME RNA;

EID: 0029998660     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.1996.0252     Document Type: Article
Times cited : (75)

References (61)
  • 1
    • 0029082529 scopus 로고
    • Structure of the P1 helix from group I self-splicing introns
    • Allain, F. H.-T. & Varani, G. (1995). Structure of the P1 helix from group I self-splicing introns. J. Mol. Biol. 250, 333-353.
    • (1995) J. Mol. Biol. , vol.250 , pp. 333-353
    • Allain, F.H.-T.1    Varani, G.2
  • 2
    • 0000265069 scopus 로고
    • Conformational analysis of nucleic acids. Determination of backbone geometry of single-helical RNA and DNA in aqueous solution
    • Altona, C. (1982). Conformational analysis of nucleic acids. Determination of backbone geometry of single-helical RNA and DNA in aqueous solution. Recueil. J. Roy. Netherlands Chem. Soc. 101, 413-433.
    • (1982) Recueil. J. Roy. Netherlands Chem. Soc. , vol.101 , pp. 413-433
    • Altona, C.1
  • 3
    • 0028902990 scopus 로고
    • Structure of an RNA double helix including uracil-uracil base pairs in an internal loop
    • Baeyens, K. J., De Bondt, H. L. & Holbrook, S. R. (1995). Structure of an RNA double helix including uracil-uracil base pairs in an internal loop. Nature Struct. Biol. 2, 56-62.
    • (1995) Nature Struct. Biol. , vol.2 , pp. 56-62
    • Baeyens, K.J.1    De Bondt, H.L.2    Holbrook, S.R.3
  • 6
    • 37049093263 scopus 로고
    • Conformational analysis of β-D-ribo, β-D-arabino-, β-D-xylo-, and β-D-lyxo-nucleotides from proton-proton coupling constants
    • de Leeuw, F. A. A. M. & Altona, C. (1982). Conformational analysis of β-D-ribo, β-D-arabino-, β-D-xylo-, and β-D-lyxo-nucleotides from proton-proton coupling constants. J. Chem. Soc. Perkin Trans. II, 2, 375-384.
    • (1982) J. Chem. Soc. Perkin Trans. II , vol.2 , pp. 375-384
    • De Leeuw, F.A.A.M.1    Altona, C.2
  • 7
    • 0029044463 scopus 로고
    • Stabilization of a conserved ribosomal RNA tertiary structure by an antibiotic and ammonium ions
    • Draper, D. E., Xing, Y. & Laing, L. G. (1995). Stabilization of a conserved ribosomal RNA tertiary structure by an antibiotic and ammonium ions. J. Mol. Biol. 249, 231-238.
    • (1995) J. Mol. Biol. , vol.249 , pp. 231-238
    • Draper, D.E.1    Xing, Y.2    Laing, L.G.3
  • 8
    • 0024349978 scopus 로고
    • Antibiotic interactions at the GTPase-associated centre within Escherichia coli 23S rRNA
    • Egebjerg, J., Douthwaite, S. & Garrett, R. A. (1989). Antibiotic interactions at the GTPase-associated centre within Escherichia coli 23S rRNA. EMBO J. 8, 607-611.
    • (1989) EMBO J. , vol.8 , pp. 607-611
    • Egebjerg, J.1    Douthwaite, S.2    Garrett, R.A.3
  • 10
    • 0027932176 scopus 로고
    • Thermodynamics of folding a pseudoknotted mRNA fragment
    • Gluick, T. C. & Draper, D. E. (1994). Thermodynamics of folding a pseudoknotted mRNA fragment. J. Mol. Biol 241, 246-262.
    • (1994) J. Mol. Biol , vol.241 , pp. 246-262
    • Gluick, T.C.1    Draper, D.E.2
  • 11
    • 84940927224 scopus 로고
    • Phosphorous-31 chemical shifts: Principles and empirical observations
    • (Gorenstein, D., ed.), Academic Press, Orlando, Florida
    • Gorenstein, D. (1984). Phosphorous-31 chemical shifts: principles and empirical observations. In Phosphorous-31 NMR (Gorenstein, D., ed.), pp. 7-36, Academic Press, Orlando, Florida.
    • (1984) Phosphorous-31 NMR , pp. 7-36
    • Gorenstein, D.1
  • 13
    • 0028856760 scopus 로고
    • Nonsense suppressor and antisuppressor mutations at the 1409-14491 base-pair in the decoding region of Escherichia coli 16S rRNA
    • Gregory S. T. & Dahlberg, A. E. (1995). Nonsense suppressor and antisuppressor mutations at the 1409-14491 base-pair in the decoding region of Escherichia coli 16S rRNA. Nucl. Acids Res. 23, 4234-4238
    • (1995) Nucl. Acids Res. , vol.23 , pp. 4234-4238
    • Gregory S, T.1    Dahlberg, A.E.2
  • 14
    • 0026539417 scopus 로고
    • A compilation of large subunit (23S and 23S-like) ribosomal RNA structures
    • Gutell, R. R., Schnare, M. N. & Gray, M. W. (1992). A compilation of large subunit (23S and 23S-like) ribosomal RNA structures. Nucl. Acids Res. 20(Suppl.), 2095-2109.
    • (1992) Nucl. Acids Res. , vol.20 , Issue.SUPPL. , pp. 2095-2109
    • Gutell, R.R.1    Schnare, M.N.2    Gray, M.W.3
  • 15
    • 20444483055 scopus 로고
    • The relationship between protein-protein NMR coupling constants and substituent electronegativities I. An empirical generalization of the Karplus equation
    • Haasnoot, C. A. G., de Leeuw, F. A. A. M. & Altona, C. (1980). The relationship between protein-protein NMR coupling constants and substituent electronegativities I. An empirical generalization of the Karplus equation. Tetrahedron, 36, 2783-2792.
    • (1980) Tetrahedron , vol.36 , pp. 2783-2792
    • Haasnoot, C.A.G.1    De Leeuw, F.A.A.M.2    Altona, C.3
  • 16
    • 0026423027 scopus 로고
    • Structural features that give rise to the unusual stability of RNA hairpins containing GNRA loops
    • Heus, H. A. & Pardi, R. (1991). Structural features that give rise to the unusual stability of RNA hairpins containing GNRA loops. Science, 252, 191-194.
    • (1991) Science , vol.252 , pp. 191-194
    • Heus, H.A.1    Pardi, R.2
  • 17
    • 48749149745 scopus 로고
    • Solvent suppression in Fourier transform nuclear magnetic resonance
    • Hore, P. J. (1983). Solvent suppression in Fourier transform nuclear magnetic resonance. J. Mag. Res. 55, 283-300.
    • (1983) J. Mag. Res. , vol.55 , pp. 283-300
    • Hore, P.J.1
  • 18
    • 0023544379 scopus 로고
    • Thiostrepton-resistance mutations in the gene for 23 S rRNA of halobacteria
    • Hummel, H. & Böck, A. (1987). Thiostrepton-resistance mutations in the gene for 23 S rRNA of halobacteria. Biochemie, 69, 857-861.
    • (1987) Biochemie , vol.69 , pp. 857-861
    • Hummel, H.1    Böck, A.2
  • 19
    • 0017055057 scopus 로고
    • Crystallographic refinement of yeast phenylalanine transfer RNA at 2.5 Å resolution
    • Jack, A., Lander, J. E. & Klug, A. (1976). Crystallographic refinement of yeast phenylalanine transfer RNA at 2.5 Å resolution. J. Mol. Biol. 108, 619-649.
    • (1976) J. Mol. Biol. , vol.108 , pp. 619-649
    • Jack, A.1    Lander, J.E.2    Klug, A.3
  • 20
    • 0027444622 scopus 로고
    • An NMR study of the HIV-1 TAR element hairpin
    • J.
    • Jaeger, J. A. & I. Tinoco, J. (1993). An NMR study of the HIV-1 TAR element hairpin. Biochemistry, 32, 12522-12530.
    • (1993) Biochemistry , vol.32 , pp. 12522-12530
    • Jaeger, J.A.1    Tinoco, I.2
  • 21
    • 0028294458 scopus 로고
    • Involvement of a gnra tetraloop in long-range RNA tertiary interactions
    • Jaeger, L., Michel, F. & Westhof, E. (1994). Involvement of a GNRA tetraloop in long-range RNA tertiary interactions. J. Mol. Biol. 236, 1271-1276.
    • (1994) J. Mol. Biol. , vol.236 , pp. 1271-1276
    • Jaeger, L.1    Michel, F.2    Westhof, E.3
  • 22
    • 0029583854 scopus 로고
    • UGA suppression by a mutant RNA of the large ribosomal subunit
    • Jemiolo, D. K., Pagel, F. T. & Murgola, E. J. (1995). UGA suppression by a mutant RNA of the large ribosomal subunit, Proc. Natl Acad. Sci. USA, 92, 12309-12313.
    • (1995) Proc. Natl Acad. Sci. USA , vol.92 , pp. 12309-12313
    • Jemiolo, D.K.1    Pagel, F.T.2    Murgola, E.J.3
  • 23
    • 0029283999 scopus 로고
    • GNRA tetraloops make a U-turn
    • Jucker, F. M. & Pardi, A. (1995a). GNRA tetraloops make a U-turn. RNA, 1, 219-222.
    • (1995) RNA , vol.1 , pp. 219-222
    • Jucker, F.M.1    Pardi, A.2
  • 24
    • 0028866812 scopus 로고
    • Solution structure of the CUUG hairpin loop: A novel RNA tetraloop motif
    • Jucker, F. M. & Pardi, A. (1995b). Solution structure of the CUUG hairpin loop: a novel RNA tetraloop motif. Biochemisty, 34, 14416-14427.
    • (1995) Biochemisty , vol.34 , pp. 14416-14427
    • Jucker, F.M.1    Pardi, A.2
  • 25
    • 0028234517 scopus 로고
    • Thermodynamics of RNA folding in a highly conserved ribosomal RNA domain
    • Laing, L. G. & Draper, D. E. (1994). Thermodynamics of RNA folding in a highly conserved ribosomal RNA domain. J. Mol. Biol. 237, 560-576.
    • (1994) J. Mol. Biol. , vol.237 , pp. 560-576
    • Laing, L.G.1    Draper, D.E.2
  • 26
    • 0028237035 scopus 로고
    • Stabilization of RNA structure by Mg ion: Specific and non-specific effects
    • Laing, L. G., Gluick, T. C. & Draper, D. E. (1994). Stabilization of RNA structure by Mg ion: specific and non-specific effects. J. Mol. Biol. 237, 577-587.
    • (1994) J. Mol. Biol. , vol.237 , pp. 577-587
    • Laing, L.G.1    Gluick, T.C.2    Draper, D.E.3
  • 27
    • 0021436726 scopus 로고
    • Carbon-13 NMR in conformational analysis of nucleic acid fragments. 2. A reparametrization of the Karplus equation for vicinal NMR coupling constants in CCOP and HCOP fragments
    • Lankhorst, P. P., Haasnoot, C. A. G., Erkelens, C. & Altona, C. (1984). Carbon-13 NMR in conformational analysis of nucleic acid fragments. 2. A reparametrization of the Karplus equation for vicinal NMR coupling constants in CCOP and HCOP fragments. J. Biomol. Struc. Dynam. 1, 1387-1405.
    • (1984) J. Biomol. Struc. Dynam. , vol.1 , pp. 1387-1405
    • Lankhorst, P.P.1    Haasnoot, C.A.G.2    Erkelens, C.3    Altona, C.4
  • 28
    • 0029116756 scopus 로고
    • Oligonucleotides containing G·A pairs: Effects of flanking sequences on structure and stability
    • Li, Y. & Agrawal, S. (1995). Oligonucleotides containing G·A pairs: effects of flanking sequences on structure and stability. Biochemistry, 34, 10056-10062.
    • (1995) Biochemistry , vol.34 , pp. 10056-10062
    • Li, Y.1    Agrawal, S.2
  • 29
    • 0026053768 scopus 로고
    • NMR and molecular modeling evidence for a new type of G-A mismatch base pair in a purine-rich DNA duplex
    • Li, Y., Zon, G. & Wilson, W. D. (1991). NMR and molecular modeling evidence for a new type of G-A mismatch base pair in a purine-rich DNA duplex. Proc. Natl Acad. Sci. USA, 88, 26-30.
    • (1991) Proc. Natl Acad. Sci. USA , vol.88 , pp. 26-30
    • Li, Y.1    Zon, G.2    Wilson, W.D.3
  • 30
    • 0028102703 scopus 로고
    • Bases defining an ammonium and magnesium ion-dependent tertiary structure within the large subunit ribosomal RNA
    • Lu, M. & Draper, D. E. (1994). Bases defining an ammonium and magnesium ion-dependent tertiary structure within the large subunit ribosomal RNA. J. Mol. Biol. 244, 572-585.
    • (1994) J. Mol. Biol. , vol.244
    • Lu, M.1    Draper, D.E.2
  • 31
    • 0028134851 scopus 로고
    • Cross-hypersensitivity effects of mutations in 23 S rRNA yield insight into aminoacyl-tRNA binding
    • Mankin, A. S., Leviev, I. & Garrett, R. A. (1994). Cross-hypersensitivity effects of mutations in 23 S rRNA yield insight into aminoacyl-tRNA binding. J. Mol. Biol. 244, 151-157.
    • (1994) J. Mol. Biol. , vol.244 , pp. 151-157
    • Mankin, A.S.1    Leviev, I.2    Garrett, R.A.3
  • 32
    • 0025678737 scopus 로고
    • Modelling of the three-dimensional architecture of group I catalytic introns based on comparative sequence analysis
    • Michel, F. & Westhof, E. (1990). Modelling of the three-dimensional architecture of group I catalytic introns based on comparative sequence analysis. J. Mol. Biol. 216, 585-610.
    • (1990) J. Mol. Biol. , vol.216 , pp. 585-610
    • Michel, F.1    Westhof, E.2
  • 33
    • 85030192717 scopus 로고    scopus 로고
    • Variety of nonsense suppressor phenotypes associated with mutational changes at conserved sites in E. coli ribosomal RNA
    • In the press
    • Murgola, E. J., Pagel, F. T., Hijazi, K. A., Arkov, A. L., Xu, W. & Zhao, S. Q. (1996). Variety of nonsense suppressor phenotypes associated with mutational changes at conserved sites in E. coli ribosomal RNA. Biochem. Cell Biol. In the press.
    • (1996) Biochem. Cell Biol.
    • Murgola, E.J.1    Pagel, F.T.2    Hijazi, K.A.3    Arkov, A.L.4    Xu, W.5    Zhao, S.Q.6
  • 34
    • 0028301674 scopus 로고
    • GAAA tetraloop and conserved bulge stabilize tertiary structure of a group I intron domain
    • Murphy, F. L. & Cech, T. R. (1994). GAAA tetraloop and conserved bulge stabilize tertiary structure of a group I intron domain. J. Mol. Biol. 236, 49-63.
    • (1994) J. Mol. Biol. , vol.236 , pp. 49-63
    • Murphy, F.L.1    Cech, T.R.2
  • 35
    • 0028063567 scopus 로고
    • Three-dimensional structure of a hammerhead ribozyme
    • Pley, H. W., Flaherty, K. M. & McKay, D. B. (1994a). Three-dimensional structure of a hammerhead ribozyme. Nature, 372, 68-74.
    • (1994) Nature , vol.372 , pp. 68-74
    • Pley, H.W.1    Flaherty, K.M.2    McKay, D.B.3
  • 36
    • 0028037302 scopus 로고
    • Model for an RNA tertiary interaction from the structure of an intermolecular complex between a GAAA tetraloop and an RNA helix
    • Pley, H. W., Flaherty, K. M. & McKay, D. B. (1994b). Model for an RNA tertiary interaction from the structure of an intermolecular complex between a GAAA tetraloop and an RNA helix. Nature, 372, 111-113.
    • (1994) Nature , vol.372 , pp. 111-113
    • Pley, H.W.1    Flaherty, K.M.2    McKay, D.B.3
  • 37
    • 0017182937 scopus 로고
    • Structural domains of transfer RNA molecules
    • Quigley, G. J. & Rich, A. (1976). Structural domains of transfer RNA molecules. Science, 194, 796-806.
    • (1976) Science , vol.194 , pp. 796-806
    • Quigley, G.J.1    Rich, A.2
  • 38
    • 0016912825 scopus 로고
    • Transfer RNA: Molecular structure, sequence, and properties
    • Rich, A. & RajBhandary, U. L. (1976). Transfer RNA: molecular structure, sequence, and properties. Annu. Rev. Biochem. 45, 805-860.
    • (1976) Annu. Rev. Biochem. , vol.45 , pp. 805-860
    • Rich, A.1    Rajbhandary, U.L.2
  • 39
    • 0028355760 scopus 로고
    • The antibiotics micrococcin and thiostrepton interact directly with 23S rRNA nucleotides 1067A and 1095A
    • Rosendahl, G. & Douthwaite, S. (1994). The antibiotics micrococcin and thiostrepton interact directly with 23S rRNA nucleotides 1067A and 1095A. Nucl. Acids Res. 22, 357-363.
    • (1994) Nucl. Acids Res. , vol.22 , pp. 357-363
    • Rosendahl, G.1    Douthwaite, S.2
  • 40
    • 0025999688 scopus 로고
    • Recognition of the highly conserved GTPase center of 23 S ribosomal RNA by ribosomal protein L11 and the antibiotic thiostrepton
    • Ryan, P. C., Lu, M. & Draper, D. E. (1991). Recognition of the highly conserved GTPase center of 23 S ribosomal RNA by ribosomal protein L11 and the antibiotic thiostrepton. J. Mol. Biol. 221, 1257-1268.
    • (1991) J. Mol. Biol. , vol.221 , pp. 1257-1268
    • Ryan, P.C.1    Lu, M.2    Draper, D.E.3
  • 42
    • 0027146665 scopus 로고
    • 2 in solution from NMR and restrained molecular dynamics
    • 2 in solution from NMR and restrained molecular dynamics. Biochemisty, 32, 12612-12623.
    • (1993) Biochemisty , vol.32 , pp. 12612-12623
    • SantaLucia J., Jr.1    Turner, D.2
  • 44
    • 0029073091 scopus 로고
    • The crystal structure of an all-RNA hammerhead ribozyme: A proposed mechanism for RNA catalytic cleavage
    • Scott, W. G., Finch, J. T. & Klug A. (1995). The crystal structure of an all-RNA hammerhead ribozyme: a proposed mechanism for RNA catalytic cleavage. Cell, 81, 991-1002.
    • (1995) Cell , vol.81 , pp. 991-1002
    • Scott, W.G.1    Finch, J.T.2    Klug, A.3
  • 45
    • 0027992843 scopus 로고
    • A model for the stabilities of RNA hairpins based on a study of the sequence dependence of stability for hairpins of six nucleotides
    • Serra, M. J., Axenson, T. J. & Turner, D. H. (1994). A model for the stabilities of RNA hairpins based on a study of the sequence dependence of stability for hairpins of six nucleotides. Biochemisty, 33, 14289-144296.
    • (1994) Biochemisty , vol.33 , pp. 14289-144296
    • Serra, M.J.1    Axenson, T.J.2    Turner, D.H.3
  • 47
    • 12044251259 scopus 로고
    • Solvent suppression with symmetrically-shifted pulses
    • Smallcombe, S. H. (1993). Solvent suppression with symmetrically-shifted pulses. J. Am. Chem. Soc. 115, 4776-4785.
    • (1993) J. Am. Chem. Soc. , vol.115 , pp. 4776-4785
    • Smallcombe, S.H.1
  • 48
    • 2642628181 scopus 로고
    • A two-dimensional nuclear overhauser experiment with pure absorption phase in four quadrants
    • States, D. J., Haberkorn, R. A. & Ruben, R. D. (1982). A two-dimensional nuclear overhauser experiment with pure absorption phase in four quadrants. J. Mag. Reson. 48, 286-292.
    • (1982) J. Mag. Reson. , vol.48 , pp. 286-292
    • States, D.J.1    Haberkorn, R.A.2    Ruben, R.D.3
  • 49
    • 0028953727 scopus 로고
    • The sarcin/ricin loop, a modular RNA
    • Szewczak, A. A. & Moore, P. B. (1995). The sarcin/ricin loop, a modular RNA. J. Mol. Biol. 247, 81-98.
    • (1995) J. Mol. Biol. , vol.247 , pp. 81-98
    • Szewczak, A.A.1    Moore, P.B.2
  • 51
    • 0026348081 scopus 로고
    • RNA structure and NMR spectroscopy
    • Varani, G. & Tinoco, I. (1991a). RNA structure and NMR spectroscopy. Quart. Rev. Biophys. 24, 479-532.
    • (1991) Quart. Rev. Biophys. , vol.24 , pp. 479-532
    • Varani, G.1    Tinoco, I.2
  • 53
    • 0024974083 scopus 로고
    • Conformation and dynamics of an RNA internal loop
    • Varani, G., Wimberly B. & Tinoco, I. (1989). Conformation and dynamics of an RNA internal loop. Biochemistry, 28, 7760-7772.
    • (1989) Biochemistry , vol.28 , pp. 7760-7772
    • Varani, G.1    Wimberly, B.2    Tinoco, I.3
  • 54
    • 0025811124 scopus 로고
    • Structure of an unusually stable RNA hairpin
    • Varani, G., Cheong, C. & Tinoco, I. (1991). Structure of an unusually stable RNA hairpin. Biochemistry, 30, 3280-3289.
    • (1991) Biochemistry , vol.30 , pp. 3280-3289
    • Varani, G.1    Cheong, C.2    Tinoco, I.3
  • 55
    • 0027374419 scopus 로고
    • Specific ammonium ion requirement for functional ribosomal RNA tertiary structure
    • Wang, Y.-X., Lu, M. & Draper, D. E. (1993). Specific ammonium ion requirement for functional ribosomal RNA tertiary structure. Biochemistry, 32, 12279-12282.
    • (1993) Biochemistry , vol.32 , pp. 12279-12282
    • Wang, Y.-X.1    Lu, M.2    Draper, D.E.3
  • 56
    • 84988053694 scopus 로고
    • An all atom force field for simulations of proteins and nucleic acids
    • Weiner, S. J., Kollman, P. A., Nguyen, D. T. & Case, D. A. (1986). An all atom force field for simulations of proteins and nucleic acids. J. Comp. Chem. 7, 230-252.
    • (1986) J. Comp. Chem. , vol.7 , pp. 230-252
    • Weiner, S.J.1    Kollman, P.A.2    Nguyen, D.T.3    Case, D.A.4
  • 57
    • 0021879256 scopus 로고
    • Crystallographic refinement of yeast aspartic acid transfer RNA
    • Westhof, E., Dumas, P. & Moras, D. (1985). Crystallographic refinement of yeast aspartic acid transfer RNA. J. Mol. Biol. 184, 119-145.
    • (1985) J. Mol. Biol. , vol.184 , pp. 119-145
    • Westhof, E.1    Dumas, P.2    Moras, D.3
  • 58
    • 0021012648 scopus 로고
    • Detailed analysis of the higher-order structure of 16S-like ribosomal ribonucleic acids
    • Woese, C. R., Gutell, R., Gupta, R. & Noller, H. F. (1983). Detailed analysis of the higher-order structure of 16S-like ribosomal ribonucleic acids. Microbiol. Rev. 47, 621-669.
    • (1983) Microbiol. Rev. , vol.47 , pp. 621-669
    • Woese, C.R.1    Gutell, R.2    Gupta, R.3    Noller, H.F.4
  • 59
    • 0025047647 scopus 로고
    • Architecture of ribosomal RNA: Constraints on the sequence of "tetra-loops"
    • Woese, C. R., Winker, S. & Gutell, R. R. (1990). Architecture of ribosomal RNA: constraints on the sequence of "tetra-loops". Proc. Natl Acad. Sci. USA, 7, 8467-8471.
    • (1990) Proc. Natl Acad. Sci. USA , vol.7 , pp. 8467-8471
    • Woese, C.R.1    Winker, S.2    Gutell, R.R.3
  • 61
    • 0029063715 scopus 로고
    • Stabilization of ribosomal RNA tertiary structure by ribosomal protein L11
    • Xing, Y. & Draper, D. E. (1995). Stabilization of ribosomal RNA tertiary structure by ribosomal protein L11. J. Mol. Biol. 246, 319-331.
    • (1995) J. Mol. Biol. , vol.246 , pp. 319-331
    • Xing, Y.1    Draper, D.E.2


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