Adjuvant hepatic arterial IL-2 and MMC, 5-FU after curative resection of colorectal liver metastases

Hepato-Gastroenterology

Volumn 43, Issue 9, 1996, Pages 688-691

  Okuno, Kiyotaka ^a   Shigeoka, Hironori ^a   Lee, Yung Sun ^a   Son, Eikan ^a   Kayama, Hitoshi ^a   Nakai, Takuya ^a   Koh, Kenzo ^a   Yasutomi, Masayuki ^a  

^a KINKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

5 fluorouracil; Hepatic arterial infusion; Interleukin 2; Liver metastases; Mitomycin C

Indexed keywords

ANTINEOPLASTIC AGENT; FLUOROURACIL; IMMUNOLOGIC AGENT; MITOMYCIN C; RECOMBINANT INTERLEUKIN 2;

ADULT; AGED; ARTICLE; BLOOD TOXICITY; CANCER SURVIVAL; CHOLANGITIS; CLINICAL ARTICLE; CLINICAL TRIAL; COLORECTAL CANCER; FEMALE; FEVER; GASTRITIS; HEPATIC ARTERY; HEPATITIS; HUMAN; INTRAARTERIAL DRUG ADMINISTRATION; LIVER METASTASIS; LIVER RESECTION; LUNG METASTASIS; MALE; PELVIS; PEPTIC ULCER; PRIORITY JOURNAL; RECURRENT CANCER;

ANTIBIOTICS, ANTINEOPLASTIC; ANTIMETABOLITES, ANTINEOPLASTIC; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; COLORECTAL NEOPLASMS; COMBINED MODALITY THERAPY; FEMALE; FLUOROURACIL; FOLLOW-UP STUDIES; HEPATECTOMY; HUMANS; IMMUNOTHERAPY; INFUSIONS, INTRA-ARTERIAL; INTERLEUKIN-2; LIVER NEOPLASMS; MALE; MIDDLE AGED; MITOMYCIN; NEOPLASM RECURRENCE, LOCAL; SURVIVAL RATE; TIME FACTORS;

EID: 0029998250     PISSN: 01726390     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (6)

1. Hughes KS, Simon R, Songhorabodi S, et al.: Resection of the liver for colorectal carcinoma metastases: A multiinstitutional study of indications for resection. Surgery 1988; 103: 278-288.
2. Okuno K, Hirohata T, Nakamura K, Jinnai H, Shigeoka H, Koh K, Shindo K, Yasutomi M: Hepatic arterial infusions of interleukin-2 (IL-2)-based immunochemotherapy in the treatment of unresectable liver metastases from colorectal cancer. Clin. Ther. 1993; 15: 672-683.
3. Bouwens L, Wisse E: Hepatic pit cells have natural cytotoxic (NC) activity against solid tumor-derived target cells. In: E. Wisse, D.L. Knook, K. Decker (eds.), The Netherlands Cells of the Hepatic Sinusoid. Rijswijk: Kupffer Cell Foundation, (1989) 215-220.
4. Takagi S, Chen K, Schwarz R, et al.: Functional and phenotypic analysis of tumor-infiltrating lymphocytes isolated from human primary and metastatic liver tumors and cultured in recombinant interleukin-2. Cancer 1989; 63: 102-111.
5. Lygidakis NJ, Ziras N, Parissis J: Resection versus resection combined with adjuvant pre- and post- operative chemotherapy- immunotherapy for metastatic colorectal liver cancer. A new look at an old problem. Hepato-Gastroenterology 42 (1995) 155-161
6. Okuno K, Kobayashi S, Jinnai H, Lee YS, Shigeoka H, Yasutomi M: IL-2 perfusion to the liver augments the hepatic extraction rate of accompanying anti-cancer drugs. Surg. Today (in press)