n-3 Polyunsaturated fatty acid-induced changes in the molecular species composition of diradylglycerol in murine peritoneal macrophages remain stable during incubation ex vivo

Lipids

Volumn 31, Issue 7, 1996, Pages 771-776

  Marignani, Paola A ^a   Sebaldt, Rolf J ^a,b  

^a MCMASTER UNIVERSITY   (Canada)

^b ST JOSEPH S HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCEROL; MEMBRANE LIPID; POLYUNSATURATED FATTY ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL MEMBRANE; CONTROLLED STUDY; DIETARY INTAKE; DRUG EFFECT; FATTY ACID SYNTHESIS; INCUBATION TIME; LIPID COMPOSITION; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; THIN LAYER CHROMATOGRAPHY;

EID: 0029998154     PISSN: 00244201     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02522894     Document Type: Article

References (9)

1. Garg, M.L., Thomson, A.B.R., and Clandinin, M.T. (1990) Interactions of Saturated n-6 and n-3 Polyunsaturated Fatty Acids to Modulate Arachidonic Acid Metabolism, J. Lipid Res. 31, 271-277.
2. Rubin, D., and Laposata, M. (1992) Cellular Interactions Between n-6 and n-3 Fatty Acids: A Mass Analysis of Fatty Acid Elongation/Desaturation, Distribution Among Complex Lipids, and Conversion to Eicosanoids, J. Lipid Res. 33, 1431-1440.
3. Marignani, P.A., and Sebaldt, R.J. (1995) Formation of Second Messenger Diradylglycerol in Murine Peritoneal Macrophages Is Altered After in vivo (n-3) Polyunsaturated Fatty Acid Supplementation, J. Nutr. 125, 3030-3040.
4. Adams, D.O. (1979) Macrophages, Methods Enzymol. 43, 494-505.
5. Sebaldt, R.J., Sheller, J.R., Oates, J.A., Roberts II, L.J., and FitzGerald, G.A. (1990) Inhibition of Eicosanoid Biosynthesis by Glucocorticoids in Humans, Proc. Natl. Acad. Sci. USA 87, 6974-6978.
6. Sebaldt, R.J., Prpic, V., Hollenbach, P.W., Adams, D.O., and Uhing, R.J. (1990) IFN-Gamma Potentiates the Accumulation of Diacylglycerol in Murine Macrophages, J. Immunol. 145, 684-689.
7. Sebaldt, R.J., Adams, D.O., and Uhing, R.J. (1992) Quantification of Contributions of Phospholipid Precursors to Diradylglycerol in Stimulated Mononuclear Phagocytes, Biochem. J. 284, 367-375.
8. Sebaldt, R.J. and Marignani, P.A. (1995) Diradylglycerol (DG) Formation Is Altered by n-3 Highly Unsaturated Fatty Acids with Marked Differences Between Eicosapentaenoic (EPA) and Docosahexaenoic (DHA) Acids: A Novel Mechanism of Action of n-3 Fatty Acids in Signal Transduction, in The 3rd International Conference on Eicosanoids & Other Bioactive Lipids in Cancer, Inflammation & Radiation Injury, (Nigam, S., Honn, K.V., and Marnett, L.J., eds.) pp. 931-939, Kluwer Academic Publishers, Boston.
9. Bligh, E.G., and Dyer, W.J. (1959) A Rapid Method of Total Lipid Extraction and Purification, Can. J. Biochem. Phvsiol. 37, 911-917.