Subcellular distribution of glucose transporter (GLUT-1) during development of the blood-brain barrier in rats

Cell and Tissue Research

Volumn 284, Issue 3, 1996, Pages 355-365

  Bolz, Sylvia ^a   Farrell, Catherine L ^b   Dietz, Klaus ^a   Wolburg, Hartwig ^a  

^a UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

^b AMGEN INC   (United States)

Author keywords

Blood brain barrier; Development; Glucose transporter (GLUT 1); Immunogold labeling; Immunohistochemistry; Rat (Sprague Dawley)

Indexed keywords

GLUCOSE TRANSPORTER;

ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; CELLULAR DISTRIBUTION; CHOROID PLEXUS; CYTOPLASM; EMBRYO; EMBRYO DEVELOPMENT; IMMUNOELECTRON MICROSCOPY; IMMUNOGOLD STAINING; IMMUNOHISTOCHEMISTRY; INTRACELLULAR MEMBRANE; MICROVASCULATURE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; BLOOD-BRAIN BARRIER; BRAIN; ENDOTHELIUM, VASCULAR; FEMALE; FETUS; GLUCOSE TRANSPORTER TYPE 1; IMMUNOHISTOCHEMISTRY; MICROCIRCULATION; MICROSCOPY, IMMUNOELECTRON; MONOSACCHARIDE TRANSPORT PROTEINS; PREGNANCY; RATS; RATS, SPRAGUE-DAWLEY; SUBCELLULAR FRACTIONS;

ANIMALIA; ORYCTOLAGUS CUNICULUS;

EID: 0029997928     PISSN: 0302766X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004410050596     Document Type: Article

References (53)

1. Aström KE, deF Webster H (1990) Preparation of fetal brains for light and electron microscopy. J Electron Microsc Tech 15: 383-386
2. Bauer H, Sonnleitner U, Lametschwandtner A, Steiner M, Adam H, Bauer HC (1995) Ontogenic expression of the erythroid-type glucose transporter (Glut 1) in the telencephalon of the mouse: correlation to the tightening of the blood-brain barrier. Dev Brain Res 86:317-325
3. Bär T (1980) The vascular system of the cerebral cortex. Adv Anal Embryol Cell Biol 59:1-62
4. Bär T, Wolff JR (1972) The formation of capillary basement membranes during internal vascularization of the rat cerebral cortex. Z Zellforsch 133:231-248
5. Bell GI, Kayano T, Buse JB, Burant CF, Takeda J, Lin D, Fukumoto H, Seino S (1990) Molecular biology of mammalian glucose transporters. Diabetes Care 13:198-208
6. Birnbaum MJ, Haspel HC, Rosen OM (1986) Cloning and characterization of a cDNA encoding the rat brain glucose-transporter protein. Proc Natl Acad Sci USA 83:5784-5788
7. Boado RJ, Pardridge WM (1990a) Molecular cloning of the bovine blood-brain barrier glucose transporter cDNA and demonstration of phylogenetic conservation of the 5-untranslated region. Mol Cell Neurosci 1:224-232
8. Boado RJ, Pardridge WM (1990b) The brain type glucose transporter messenger RNA is specifically exposed at the blood-brain barrier. Biochem Biophys Res Commun 166:174
9. Cornford EM, Hyman S, Pardridge WM (1993) An electron microscopic immunogold analysis of developmental up-regulation of the blood-brain barrier GLUT1 glucose transporter. J Cereb Blood Flow Metab 13:841-854
10. Cornford EM, Hyman S, Landaw EM (1994) Development modulation of blood-brain-barrier glucose transport in the rabbit. Brain Res 663:7-18
11. Dermietzel R, Krause D (1991) Molecular anatomy of the blood-brain barrier as defined by immunocytochemistry. Int Rev Cytol 127:57-109
12. Dermietzel R, Krause D, Kremer M, Wang C, Stevenson B (1992) Pattern of glucose transporter (Glut 1) expression in embryonic brains is related to maturation of blood-brain barrier tightness. Dev Dyn 193:152-163
13. Devaskar S, Zahm DS, Holtzclaw L, Chundu R, Wadzinski BE (1991) Developmental regulation of the distribution of rat brain insulin-insensitive (Glut-1) glucose transporter. Endocrinology 129:1530-1540
14. Dwyer KJ, Pardridge WM (1993) Developmental modulation of blood-brain barrier GLUT1 glucose transporter gene expression and immunoreactive protein in rabbits. Endocrinology 132:558-565
15. Dyve S, Gjedde A (1991) Glucose metabolism of fetal rat brain in utero, measured with labeled deoxyglucose. Acta Neurol Scand 83:14-19
16. Dzieglielewska KM, Evans CA, Malinowska DH, Møllgard K, Reynolds JM, Reynolds ML, Saunders NR (1979) Studies of the development of brain-barrier systems to lipid insoluble molecules in fetal sheep. J Physiol 292:207-231
17. Farrell CL, Pardridge WM (1991) Blood-brain barrier glucose transporter is asymmetrically distributed on brain capillary endothelial lumenal and ablumenal plasma membranes: an electron microscopic immunogold study. Proc Natl Acad Sci USA 885:779-783
18. Farrell CL, Risau W (1994) Normal and abnormal development of the blood-brain barrier. Microsc Res Tech 27:495-506
19. Fuglsang A, Lomholt M, Gjedde A (1986) Blood-brain barrier transfer of glucose analogs in newborn rats. J Neurochem 46: 1417-1428
20. Gerhart DZ, Levasseur RJ, Broderius MA, Drewes LR (1989) Glucose transporter localization in brain using light and electron microscopy. J Neurosci Res 22:464-472
21. Gerhart DZ, Broderius MA, Borson ND, Drewes LR (1992) Neurons and microvessels express the brain glucose transporter protein GLUT3. Proc Natl Acad Sci USA 89:733-737
22. Goldstein GW, Betz LA (1983) Recent advances in understanding brain capillary function. Ann Neurol 14:389-395
23. Harik SI, Kalaria RN, Andersson L, Perry G (1990) Immunocytochemical localization of the erythroid glucose transporter: abundance in tissue with barrier function. J Neurosci 10: 3862-3872
24. Harik SI, Hall AK, Richey P, Andersson L, Lundahl P, Perry G (1993) Ontogeny of the erythroid/HepG2-type glucose transporter (GLUT-1) in the rat nervous system. Dev Brain Res 72: 41-49
25. Haspel HC, Rosenfeld MG, Rosen OM (1988) Characterization of antisera to a synthetic carboxyl-terminal peptide of the glucose transporter protein. J Biol Chem 263:398-403
26. Hawkins RA, Williamson DH, Krebs HA (1971) Ketone-body utilization by adult and suckling rat brain in vivo. Biochem J 122:13
27. Hsu S, Raine L, Fanger H (1981) A comparative study of the peroxidase method and an avidin-biotin complex method for studying polypeptide hormone with radiommunoassay antibodies. J Clin Pathol 75:734
28. Johanson CE (1980) Permeability and vascularity of the developing brain: cerebellum vs cerebral cortex. Brain Res 190:3-16
29. Kasanicki MA, Cairns MT, Davies A, Gardiner RM, Baldwin SA (1987) Identification and characterization of the glucose transport protein of the bovine blood brain barrier. Biochem J 247: 101-108
30. Maher F, Vannucci SJ, Simpson IA (1994) Glucose transporter proteins in brain. FASEB J 8:1003-1011
31. McKay RDG (1989) The origins of cellular diversity in the mammalian central systems. Cell 58:815-821
32. Morin AM, Dwyer BE, Fujikawa DG, Wasterlain CG (1988) Low (3H) cytochalasin B binding in the cerebral cortex of newborn rats. J Neurochem 51:206-211
33. Morgello S, Uson RR, Schwarz E, Haber RS (1995) The human blood-brain barrier glucose transporter (Glut1) is a glucose transporter of gray matter astrocytes. Glia 14:43-54
34. Mueckler M, Caruso C, Baldwin SA, Panico M, Blench I, Morris HR, Allard WJ, Lienhard GF, Lodish HF (1985) Sequence and structure of a human glucose transporter. Science 229:941-945
35. Nehlig A, Pereira de Vasconcelos A, Boyet S (1989) Postnatal changes in local cerebral blood flow measured by quantitative autoradiographic 14(C) iodoantipyrine technique in freely moving rats. J Cereb Blood Flow Metab 9:579-588
36. Olsson Y, Klatzo I, Sourander P, Steinwall O (1968) Blood-brain barrier to albumin in embryonic, newborn and adult rats. Acta Neuropathol 10:117-122
37. Pappenheimer JR, Setchell BP (1973) Cerebral glucose transport and oxygen consumption in sheep and rabbits. J Physiol 233:529-551
38. Pardridge WM, Boado RJ (1993) Molecular cloning and regulation of gene expression of blood-brain-barrier glucose transporter. In Pardridge WM (ed.) The blood-brain barrier - cellular and molecular biology. Raven Press, New York, pp 395-440
39. Pardridge WM, Boado RJ, Farrell CR (1990) Brain-type glucose transporter (Glut-1) is selectivly localized to the blood-brain barrier. J Biol Chem 265:18035-18040
40. Raju T, Bagnami A, Dahl D (1981) In vivo and in vitro differentiation of neurons and astrocytes in the rat embryo. Dev Biol 85:344-357
41. Reese TS, Karnovsky MJ (1967) Fine structural localization of a blood-brain barrier to exogenous peroxidase. J Cell Biol 34: 207-217
42. Risau W (1991) Induction of blood-brain barrier endothelial cell differentiation. Ann NY Acad Sci 633:405-417
43. Risau W, Wolburg H (1990) Development of the blood-brain barrier. Trends Neurosci 13:174-178
44. Risau W, Hallmann R, Albrecht U (1986) Differentiation dependent expression of proteins in brain endothelium during development of the blood-brain barrier. Dev Biol 117:537-545
45. Sadiq F, Holtzclaw L, Chundu K, Muzzafar A, Devaskar S (1990) The ontogeny of the rabbit brain glucose transporter. Endocrinology 126:2417-2424
46. Sivitz W, DeSautel S, Walker SW, Pessin JE (1989) Regulation of the glucose transporter in developing rat brain. Endocrinology 124:1875-1880
47. Shepherd PR, Gibbs EM, Wesslau C, Gould GW, Kahn BB (1992) Small intestine glucose transporter (GLUT5) is present in human muscle, adipocytes and brain: biochemical characterization and translocation. Diabetes 41:43
48. Stewart PA, Hayakawa EM (1987) Interendothelial junctional changes underlie the developmental tightening of the blood-brain barrier. Dev Brain Res 32:271-281
49. Steward PA, Hayakawa K (1994) Early ultrastructural changes in blood-brain barrier vessels of the rat embryo. Dev Brain Res 78:25-34
50. Stewart PA, Wiley MJ (1981) Developing nervous tissue induces formation of blood-brain barrier characteristics in invading endothelial cells: a study using quail-chick transplantation chimeras. Dev Biol 84:183-192
51. Sokoloff L (1973) Metabolism of ketone bodies by the brain. Annu Rev Med 24:271-280
52. Sokoloff L (1977) Relation between physiological function and energy metabolism in the central nervous system. J Neurochem 29:13-26
53. Yoshida Y, Yamada M, Wakabayashi K, Ikuta F (1988) Endothelial fenestrae in the rat fetal cerebrum. Dev Brain Res 44:211-219