The total synthesis of pamamycin 607. 1. Synthesis of a C1′-C11′ synthon

Tetrahedron Letters

Volumn 37, Issue 21, 1996, Pages 3751-3754

  Mavropoulos, Irene ^a   Perlmutter, Patrick ^a  

^a MONASH UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

MACROLIDE; PAMAMYCIN 607; UNCLASSIFIED DRUG;

ARTICLE; DRUG SYNTHESIS; REACTION ANALYSIS; STEREOCHEMISTRY;

EID: 0029997910     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/0040-4039(96)00638-7     Document Type: Article

References (17)

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14. Minor impurities (due to the incomplete enantioselectivity in the reduction leading to hydroxyester 3) were difficult to separate and were carried through to compound 2 where they could be completely removed.
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16. 4: 245.176. Found 245.176 ± 0.002.
17. For an alternative approach to an intermediate for this subunit, see: Walkup, R. D.; Kim, Y. S. Tetrahedron Lett. 1995, 36, 3091-3094.