Synthesis and pharmacological evaluation of N-(6-functionalized-amino-3-pyridyl)-N′-bicycloalkyl-N″- cyanoguanidines as antihypertensive agents

Chemical and Pharmaceutical Bulletin

Volumn 44, Issue 2, 1996, Pages 307-313

  Eda, Masahiro ^a   Takemoto, Tadahiro ^a   Okada, Takehiro ^a   Sakashita, Hiroshi ^a   Matzno, Sumio ^a   Gohda, Maki ^a   Hayashi, Kazutaka ^a   Nakamura, Norifumi ^a   Fukaya, Chikara ^a  

^a Green Cross Company   (South Korea)

Author keywords

Antihypertensive agent; Functionalized congener approach; Potassium channel opener

Indexed keywords

ANTIHYPERTENSIVE AGENT; GUANIDINE DERIVATIVE; N (6 AMINO 3 PYRIDYL) N' (BICYCLO[2.2.1]HEPT 2 YL) N'' CYANOGUANIDINE; POTASSIUM CHANNEL;

AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIHYPERTENSIVE ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG POTENCY; DRUG SYNTHESIS; ELECTROLYTE BALANCE; HYPERPOLARIZATION; HYPERTENSION; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION; VASCULAR SMOOTH MUSCLE;

ANIMALS; ANTIHYPERTENSIVE AGENTS; BLOOD PRESSURE; DEPRESSION, CHEMICAL; DIURETICS; GUANIDINES; HYPERTENSION; MALE; MUSCLE, SMOOTH, VASCULAR; PINACIDIL; PORTAL VEIN; POTASSIUM CHANNELS; RATS; RATS, INBRED SHR; RATS, WISTAR; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0029997329     PISSN: 00092363     EISSN: None     Source Type: Journal    
DOI: 10.1248/cpb.44.307     Document Type: Article

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