Inhibition of gap junction intercellular communications of cultured rat hepatocytes by ethanol: Role of ethanol metabolism

Journal of Hepatology

Volumn 24, Issue 3, 1996, Pages 360-367

  Hashieh, Imad Abou ^a   Mathieu, Sylvie ^a   Besson, Florence ^a   Gerolami, André ^a  

^a INSERM   (France)

Author keywords

4 methyl pyrazole; acetaldehyde; connexin 32; ethanol metabolism; intercellular communications

Indexed keywords

4 METHYLPYRAZOLE; ACETALDEHYDE; ALCOHOL; GAP JUNCTION PROTEIN; OCTANOL;

ALCOHOL METABOLISM; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL COMMUNICATION; CELL JUNCTION; CONTROLLED STUDY; LIVER CELL; LIVER CELL CARCINOMA; LIVER TOXICITY; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; RAT;

EID: 0029997246     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-8278(96)80017-1     Document Type: Article

References (30)

1. Caveney S. The role of gap junctions in development. Annu Rev Physiol 1985; 47: 319-35.
2. Fraser SE, Green CR, Bode HR, Gillula NB. Selective disruption of gap junctional communication interferes with a patterning process in hydra. Science 1987; 237: 49-55.
3. Loewenstein WR. Junctional intercellular communication and the control of growth. Biochem Biophys Acta 1979; 560: 1-65.
4. Sheridan JD, Finbow ME, Pitts JD. Metabolic interactions between animal cells through permeable intercellular junctions. Exp Cell Res 1979; 123: 111-7.
5. Sheridan JD, Atkinson MM. Physiological roles of permeable junctions; some possibilities. Annu Rev Physiol 1985; 47: 337-53.
6. Saez JC, Connor JA, Spray DC, Bennett MVL. Hepatocyte gap junctions are permeable to a second messenger, inositol 1, 4,5-triphosphate, and to calcium ions. Proc Natl Acad Sci USA 1989; 86: 2708-12.
7. Johnston MV, Simon SA, Ramon F. Interaction of anesthetics with electrical synapses. Nature 1980; 286: 498-500.
8. Spray DC, Geinzberg RD, Morales EA, Gratmaitan Z, Arias IM. Electrophysiological properties of gap junctions between dissociated pairs of rat hepatocytes. J Cell Biol 1986; 103: 135-44.
9. Chanson M, Bruzzone R, Bosco D, Meda P. Effects of n-alcohols on junctional coupling and amylase secretion of pancreatic acinar cells. J Cell Physiol 1989; 139: 147-56.
10. Lars Bastiaanse EM, Jongsma HJ, Van Der Laarse A, Takens-Kwak BR. Heptanol-induced decrease in cardiac gap junctional conductance is mediated by a decrease in the fluidity of membranous cholesterol-rich domains. J Membr Biol 1993; 136: 135-45.
11. White RL, Spray DC, Campos de Carvalho AC, Wittenberg BA, Bennett MVL. Some physiological and pharmacological properties of cardiac myocytes dissociated from adult rat. Am J Physiol 1985; 249: C447-55.
12. Spray DC, While RL, Campos de Carvalho AC, Harris AL, Bennet MVL. Gating of gap junction channels. Biophys J 1984; 45: 219-30.
13. Takens-Kwak BR, Jongsma HJ, Rook MB, Van Ginneken ACG. Mechanism of heptanol-induced uncoupling of cardiac gap junctions: a perforated patch-clamp study. Am J Physiol 1992; 262: C1531-8.
14. Abou Hashieh I, Mathieu S, Gerolami A. Effects of ethanol on intercellular communications and polarization of hepatocytes in short-term culture. Hepatology 1992; 15: 751-6.
15. Lieber CS. Metabolic effects of ethanol and its interaction with other drugs, hepatotoxic agents, vitamins, and carcinogens: a 1988 update. Semin Liver Dis 1988; 8: 47-68.
16. Seglen PO. Preparation of isolated rat liver cells. Methods Cell Biol 1975; 13: 29-83.
17. Thomas JA, Buchsbaum RN, Zimniac Z, Racker E. Intracellular pH measurements in Ehrlich ascites tumor cells utilizing spectroscopic probes generated in situ. Biochemistry 1979; 18: 2210-8.
18. Cornell NW, Hansch C, Kim KH, Henegar K. The inhibition of alcohol dehydrogenase in vitro and in isolated hepatocytes by 4-substituted pyrazoles. Arch Biochem Biophys 1993; 227: 81-90.
19. Desmoulin F, Canioni P, Crotte C, Gérolami A, Cozzone PJ. Hepatic metabolism during acute ethanol administration: a phosphorus-31 nuclear magnetic resonance study on the perfused rat liver under normoxic or hypoxic conditions. Hepatology 1987; 7: 315-23.
20. Chanson M, Bruzzone R, Bosco D, Meda P. Effects of n-alcohols on junctional coupling and amylase secretion of pancreatic acinar cells, J Cell Physiol 1989; 139: 147-56.
21. Tuma DJ, Sorrell MF. Effects of ethanol on protein trafficking in the liver. Semin Liver Dis 1988; 8: 69-80.
22. Maillard ME, Sorrel MF, Volentine GD, Tuma DJ. Impaired plasma membrane glycoprotein assembly in the liver following acute ethanol administration. Biochem Biophys Res Commun 1984; 123: 951-8.
23. Ueshima Y, Matsuda Y, Wang BY, Takase S, Takada A. Ethanol and acetaldehyde metabolism in cultured rat hepatocytes. Alcohol Alcohol 1993; 28: 3-10.
24. Rose B, Rick R. Intracellular pH, intracellular free Ca, and junctional cell-cell coupling. J Membr Biol 1978; 44: 377-415.
25. Reber WR, Weingart R. Ungulate cardiac Purkinje fibres: the influence of intracellular pH on the electrical cell-to-cell coupling. J Physiol (Lond) 1982; 328: 87-104.
26. Iwatsuki N, Petersen OH. Pancreatic acinar cells: the effect of carbon dioxide, ammonium chloride, and acetylcholine on intercellular communication. J Physiol (Lond) 1979; 291: 317-26.
27. Spray DC, Bennett MVL. Physiology and pharmacology of gap junctions. Annu Rev Physiol 1985; 47: 281-303.
28. Loewenstein WR. Junctional intercellular communication: the cell-to-cell membrane channel. Physiol Rev 1981; 61: 829-913.
29. Traub O, Look J, Dermietzel R, Brummer F, Hulser D, Willecke K. Comparative characterization of the 21-kD and 26-kD gap junction proteins in murine liver and cultured hepatocytes. J Cell Biol 1989; 108: 1039-51.
30. Zhang JL, Nicholson BJ. Sequence and tissue distribution of a second protein of hepatic gap junctions, Cx26, as deduced from its cDNA. J Cell Biol 1989; 109: 3391-401.