Antiprogestins inhibit the binding of opioids to μ-opioid receptors in nervous membrane preparations

European Journal of Pharmacology

Volumn 301, Issue 1-3, 1996, Pages 169-177

  Maggi, Roberto ^a,b   Pimpinelli, Federica ^a   Casulari, Luiz A ^a   Piva, Flavio ^a   Martini, Luciano ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b Department of Endocrinology ^*  (Italy)

Author keywords

Nervous system; Neuroblastoma; Opioid receptor; Steroid

Indexed keywords

3ALPHA HYDROXY 5ALPHA PREGNAN 20 ONE; 5ALPHA PREGNANE 3,20 DIONE; 5ALPHA PREGNANE 3ALPHA, 20ALPHA DIOL; 5ALPHA PREGNANE 3BETA OL 20 ONE; ANDROSTANOLONE; ANDROSTEN 3BETA, 17BETA DIOL; ANTIGESTAGEN; CORTICOSTERONE; CYCLIC AMP; DIHYDROMORPHINE; DIPRENORPHINE; ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; ESTRADIOL; GLUCOCORTICOID ANTAGONIST; HYDROXYPROGESTERONE; MIFEPRISTONE; MORPHINE; MU OPIATE RECEPTOR; ONAPRISTONE; OPIATE; PREGNANEDIONE; PROGESTERONE; PROSTAGLANDIN E1; RADIOLIGAND; TAMOXIFEN; TESTOSTERONE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BINDING KINETICS; BRAIN MEMBRANE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISSOCIATION CONSTANT; FEMALE; HUMAN; HUMAN CELL; MALE; MOUSE; NEUROBLASTOMA CELL; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR AFFINITY; RECEPTOR BINDING;

EID: 0029997023     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-2999(96)00003-9     Document Type: Article

References (55)

1. Belelli, D., N.C. Lan and K.W. Gee, 1990, Anticonvulsant steroids and the GABA/henzodiazepine receptor-chloride ionophore complex, Neurosci. Biobehav. Rev. 14, 315.
2. Bhanot, R. and M. Wilkinson, 1984, The inhibitory effect of opiates on gonadotrophin secretion is dependent upon gonadal steroids, J. Endocrinol. 102, 133.
3. Bradford, M.M., 1976. A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding, Anal. Biochem. 72, 248.
4. Bradley, J.V.V., D.J. Anderson and J.A. Hill, 1989, The effects of RU486 on immune function and steroid-induced immunosuppression in vitro, J. Clin. Endocrinol. Metab. 69, 1195.
5. Casulari, L.A., R. Maggi, D. Dondi, P. Limonta, F. Piva, M. Motta and L. Martini, 1987, Effect of oestrus cyclicity on the number of brain opioid μ receptors in the rat, Horm. Metab. Res. 19, 549.
6. Celotti, F., R.C. Melcangi and L. Martini, 1992. The 5 α-reductase in the brain: molecular aspects and relation to brain function, Front. Neuroendocrinol. 13, 163.
7. Cull. F.C.J., 1988, Reduction in tumor necrosis factor receptor affinity and cytotoxicity by glucocorticoids, Biochem. Biophys. Res. Commun. 153, 402.
8. De Lean, A., P.J. Munson and D. Rodbard, 1978, Simultaneous analysis of families of sigmoidal curves: application to bioassay, radioligand assay, and physiological dose-response curves, Am. J. Physiol. 235, 97.
9. Donahoe, R.M. and A. Falek, 1988, Neuroimmunomodulation by opiates and other drugs of abuse: relationship to HIV infection and AIDS, in: Psychological Neuropsychiatrie and Substance Abuse Aspects of AIDS. eds. T.P. Bridge et al. (Raven Press, New York) p. 145.
10. Dondi, D., P. Limonta, R. Maggi and F. Piva, 1992, Effects of ovarian hormones on brain opioid μ binding sites in castrated female rats, Am. J. Physiol. 263, 507.
11. Gabriel, S.M., J.W. Simpkins and S.P. Kalra, 1983, Modulation of endogenous opioid influence on luteinizing hormone secretion by progesterone and estrogen. Endocrinology 113, 1806.
12. Gee, K.W., M.B. Bolger, R.E. Brinton, H. Coirini and B.S. McEwen, 1988, Steroid modulation of the chloride ionophore in rat brain: structure-activity requirements, regional dependence and mechanism of action, J. Pharmacol. Exp. Ther. 246, 803.
13. Guardabasso, V., P.J. Munson and D. Rodbard, 1988, EXPFIT: a program for simultaneous analysis of families of exponential decay curves, Comput. Methods Progr. Biomed. 27, 55.
14. Hidalgo, J., M. Giralt, J.S. Garvey and A. Armario, 1991, Effect of morphine administration on rat liver metallothionein and zinc metabolism, J. Pharmacol. Exp. Ther. 259, 274.
15. 3H]naloxone) binding are associated with the progesterone-induced luteinizing hormone surge, Endocrinology 124, 199.
16. Kahn, C.R., I.D. Goldfine, D.M.J. Neville and P. De Meyts, 1978, Alterations in insulin binding induced by changes in vivo in the levels of glucocorticoids and growth hormone, Endocrinology 103, 1054.
17. Kalra, S.P., 1993. Mandatory neuropeptide-steroid signaling for the preovulatory luteinizing hormone-releasing hormone discharge, Endocr. Rev. 14, 507.
18. 125I-bovine serum albumin as a ligand, J. Neurochem. 54, 467.
19. Klangkalya, B. and A. Chan, 1988, Inhibition of hypothalamic and pituitary muscarinic receptor binding by progesterone, Neuroendocrinology 47, 294.
20. Knox, K.L., S.J. Ringstrom and N.B. Schwartz, 1993, RU486 blocks the effect of inhibin antiserum or luteinizing hormone on the secondary follicle-stimulating hormone surge, Endocrinology 133, 277.
21. Law, P.Y., D.S. Horn and H.H. Loh, 1983, Opiate receptor down-regulation and desensitization in neuroblastoma X glioma NG 108-15 hybrid cells are two separate cellular adaptation processes, Mol. Pharmacol. 24, 413.
22. Leslie, P.M., 1987, Methods used for the study of opioid receptors, Pharmacol. Rev. 39, 197.
23. 2-dopamine receptor agonist binding state after an acute physiological dose of 17beta-estradiol, Neurosci. Lett. 88, 113.
24. Limonta, P., F. Piva, R. Maggi, D. Dondi, M. Motta and L. Martini, 1986, Morphine stimulates prolactin release in normal but not in castrated male rats, J. Reprod. Fertil. 76, 745.
25. Liu, J.H., V.G. Garzo and S. Yen, 1988, Pharmacodynamics of the antiprogesterone RU 486 in women after oral administration, Fertil. Steril. 50, 245.
26. Maggi, R. and E. Rovati, 1993, MacEllipse, a graphical aid to the problem of the joint confidence region: a practical example for ligand binding experiments, Pharmacol. Res. 28, 351.
27. Maggi, R., P. Limonta, D. Dondi and F. Piva, 1989, Effect of ovarian steroids on the concentration of mu opiate receptors in different regions of the brain of the female rat, Pharmacol. Res. 21, 91.
28. Maggi, R., D. Dondi, E. Rovati, L. Martini, F. Piva and P. Limonta, 1993, Binding characteristics of hypothalamic μ opioid receptors throughout the estrous cycle in the rat, Neuroendocrinology 58, 366.
29. Maggi, R., L. Martini and F. Piva, 1994, Effect of ovariectomy on the binding characteristics of hypothalamic mu opioid receptors in the rat, Endocr. Regul. 28, 171.
30. Magnan, J., S. Paterson, A. Tavani and H. Kosterlitz, 1982, The binding spectrum of narcotic analgesic drugs with different agonist and antagonist properties, Naunyn-Schmied. Arch. Pharmacol. 319, 197.
31. Majewska, M.D., 1990, Steroid regulation of the GABAA receptor: ligand binding, chloride transport and behaviour, in: Steroids and Neuronal Activity, eds. D. Chadwick and K. Widdows, Ciba Foundation Symposium 153 (John Wiley and Sons, Chichester) p. 83.
32. Majewska, M.D., N.L. Harrison and R.D. Schwartz, 1986, Steroid hormone metabolites are barbiturate-like modulators of the GABA receptor, Science 232, 1004.
33. 2H NMR, in: Steroids and Neuronal Activity, eds. D. Chadwick and K. Widdows, Ciba Foundation Symposium 153 (John Wiley and Sons. Chichester) p. 172.
34. Minami, T., Y. Oomura, J. Nabekura and A. Fukuda, 1990, 17β-Estradiol depolarization of hypothalamic neurons is mediated by cyclic AMP, Brain Res. 519, 301.
35. Monterroso, V.H. and P.J. Hansen, 1993, Regulation of bovine and ovine lymphocyte proliferation by progesterone: modulation by steroid receptor antagonists and physiological status, Acta Endocrinol. 129, 532.
36. Munson, P.J. and D. Rodbard, 1980, LIGAND: a versatile computerized approach for characterization of ligand-binding system, Anal. Biochem. 107, 220.
37. Paterson, S.J., L.E. Robson and H.W. Kosterliz, 1983, Classification of opioid receptors, Br. Med. Bull. 39, 31.
38. Pert, C.B. and S.H. Snyder, 1974, Opiate receptor binding of agonists and antagonists affected differentially by sodium, Mol. Pharmacol. 10, 868.
39. 1-adrenergic receptor augmentation of cAMP formation in rat hypothalamic slices, Neuroendocrinology 55, 1.
40. Pfeiffer, A. and A. Herz, 1982, Different types of opiate agonists interact distinguishably with mu, delta and kappa opiate binding sites, Life Sci. 31, 1355.
41. Piva, F., R. Maggi, P. Limonta, M. Motta and L. Martini, 1985, Effect of naloxone on luteinizing hormone, follicle-stimulating hormone and prolactin secretion in the different phases of the estrus cycle, Endocrinology 117, 766.
42. Piva, F., P. Limonta, R. Maggi and L. Martini, 1986, Stimulatory and inhibitory effects of the opioids on gonadotropin secretion, Neuroendocrinology 42, 504.
43. Puttfarcken, P., L.L. Werling, S.R. Brown, T.E. Cote and B.M. Cox, 1986, Sodium regulation of agonist binding at opioid receptors. I. Effects of sodium replacement on binding at μ- and δ-type receptors in 7315c and NG108-15 cells and cell membranes, Mol. Pharmacol. 30, 81.
44. Ramirez, V.D., D.E. Dluzen and F.C. Ke, 1990, Effect of progesterone and its metabolites on neuronal membranes, in: Steroids and Neuronal Activity, eds. D. Chadwick and K. Widdows, Ciba Foundation Symposium 153 (John Wiley and Sons, Chichester) p. 125.
45. Remmers, A.E., G.L. Nordby and F. Medzihradsky, 1990, Modulation of opioid receptor binding by cis and trans fatty acids, J. Neurochem. 55, 1993.
46. Saphier, D. and S. Feldman, 1988, Iontophoretic application of glucocorticoids inhibit identified neurones in the paraventricular nucleus, Brain Res. 453, 183.
47. Sargent, D.F. and R. Schwyzer, 1986, Membrane lipid phase as catalyst for peptide receptor interactions, Proc. Natl. Acad. Sci. USA 83, 5774.
48. Schwarz, S. and P. Pohl, 1994, Steroid and opioid receptors, J. Steroid Biochem. Mol. Biol. 48, 391.
49. Schwarz, S., P. Phol and G.Z. Zhou, 1989, Steroid binding at σ-'opioid' receptors, Science 246, 1635.
50. Su, T.P., E.D. London and J.H. Jaffe, 1988, Steroid binding at a receptors suggests a link between endocrine, nervous and immune system, Science 240, 219.
51. Sutanto, W., G. Handelmann, F. De Bree and R. De Kloet, 1989, Multifacet interaction of corticosteroids with the intracellular recep-tors and with membrane GABA-A receptor complex in the rat brain, J. Neuroendocrinol. 1, 243.
52. Towle, A.C. and P.Y. Sze, 1983, Steroid binding to synaptic plasma membrane: differential binding of glucocorticoids and gonadal steroids, J. Steroid Biochem. 18, 135.
53. Wehling, M., 1994, Nongenomic actions of steroid hormones, Trends Endocrinol. Metab. 5, 347.
54. Weiland, N.G. and P.M. Wise, 1990, Estrogen and progesterone regulate opiate receptor density in multiple brain regions, Endocrinology 126, 804.
55. Yu, C.V.. M.L. Richards and W. Sadée, 1986, A human neuroblastoma cell line expresses μ and δ opioid receptor sites, J. Biol. Chem. 261, 1065.