Binding of fibrin monomer and heparin to thrombin in a ternary complex alters the environment of the thrombin catalytic site, reduces affinity for hirudin, and inhibits cleavage of fibrinogen

Journal of Biological Chemistry

Volumn 271, Issue 42, 1996, Pages 26088-26095

  Hogg, Philip J ^a,b   Jackson, Craig M ^b,e   Labanowski, Jan K ^c   Bock, Paul E ^b,d  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

^b AMERICAN RED CROSS BLOOD SERVICES   (United States)

^c OHIO SUPERCOMPUTER CENTER   (United States)

^d VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^e NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTICOAGULANT AGENT; ANTITHROMBIN; FIBRIN; FIBRINOGEN; HEPARIN; HIRULOG; LEPIRUDIN; THROMBIN;

ARTICLE; BINDING AFFINITY; BLOOD CLOTTING; CATALYSIS; COMPLEX FORMATION; ENZYME ACTIVITY; HUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; SPECTROFLUOROMETRY;

ANILINO NAPHTHALENESULFONATES; BINDING SITES; CATALYSIS; FIBRIN FIBRINOGEN DEGRADATION PRODUCTS; FIBRINOGEN; HEPARIN; HIRUDINS; HUMANS; PROTEIN CONFORMATION; SPECTROMETRY, FLUORESCENCE; THROMBIN;

EID: 0029995667     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.271.42.26088     Document Type: Article

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