Molecular aspects of the ectopic ACTH syndrome

Endocrine-Related Cancer

Volumn 3, Issue 2, 1996, Pages 99-112

  De Keyzer, Y ^a,b   Vieau, D ^a   Picon, A ^a   Bertagna, X ^a  

^a INSTITUT COCHIN   (France)

^b INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; CORTICOTROPIN; DEXAMETHASONE; GLUCOCORTICOID RECEPTOR; HYDROCORTISONE; MESSENGER RNA; PROOPIOMELANOCORTIN; VASOPRESSIN; VASOPRESSIN V3 RECEPTOR;

DNA SEQUENCE; ECTOPIC CORTICOTROPIN PRODUCTION; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE MAPPING; GENETIC TRANSCRIPTION; HORMONE SYNTHESIS; HUMAN; HYPOPHYSIS TUMOR; NEUROENDOCRINE TUMOR; NONHUMAN; NORTHERN BLOTTING; PHEOCHROMOCYTOMA; REVIEW; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION;

EID: 0029995626     PISSN: 13510088     EISSN: None     Source Type: Journal    
DOI: 10.1677/erc.0.0030099     Document Type: Review

References (86)

1. Abe K, Nicholson WE, Liddle GW, Orth DN & Island DP 1969 Normal and abnormal regulation of β-MSH in man. Journal of Clinical Investigation 45 1580-1585.
2. Arnold A 1993 Molecular genetics of parathyroid gland neoplasia. Journal of Clinical Endocrinology and Metabolism 77 1108-1112.
3. Autelitano DJ, Lundblad JR, Blum M & Roberts JL 1989 Hormonal regulation of POMC gene expression. Annual Review of Physiology 51 715-726.
4. Benjannet S, Rondeau N, Day R, Chretien M & Seidah NG 1991 PC1 and PC2 are proprotein convertases capable of cleaving proopiomelanocortin at distinct pairs of basic residues. Proceedings of the National Academy of Sciences of the USA 88 3564-3568.
5. Bertagna X, Nicholson WE, Sorenson GD, Pettengill OS, Mount CD & Orth DN 1978 Corticotropin, lipotropin, and β-endorphin production by a human nonpituitary tumor in tissue culture: evidence for a common precursor. Proceedings of the National Academy of Sciences of the USA 75 5160-5164.
6. Bertagna X, Lenne F, Comar D, Massias JF, Wajcman H, Baudin V, Luton, JP & Girard F 1986 Human beta-melanocyte stimulating hormone revisited. Proceedings of the National Academy of Sciences of the USA 83 9719-9723.
7. Bertagna X, Favrod-Coune C, Escourolle H, Beuzeboc P, Christoforov B, Girard F & Luton JP 1989 Suppression of ectopic ACTH secretion by the long-acting somatostatin analog SMS 201-995. Journal of Clinical Endocrinology and Metabolism 68 988-991.
8. Bloomfield GA, Scott AP, Lowry PJ, Gilkes JJH & Rees LH 1974 A reappraisal of human β-MSH. Nature 252 492-493.
9. Bodner M, Castrillo JL, Theill LE, Deerinck T, Ellisman M & Karin M 1988 The pituitary specific transcription factor GH-1 is a homeobox-containing protein. Cell 55 505-518.
10. de Bold CR, Schworer ME, Connor TB, Bird RE & Orth DN 1983 Ectopic pro-opiomelanocortin: sequence of cDNA coding for β-melanocyte stimulating hormone and β-endorphin. Science 220 721-723.
11. de Bold CR, Menefee JK, Nicholson WE & Orth DN 1988a Proopiomelanocortin gene is expressed in many normal tissues and in tumors not associated with ectopic adrenocorticotropin syndrome. Molecular Endocrinology 2 862-870.
12. de Bold CR, Nicholson WE & Orth DN 1988b Immunoreactive proopiomelanocortin (POMC) peptides and POMC-like messenger ribonucleic acid are present in many rat nonpituitary tissues. Endocrinology 122 2648-2657.
13. Boutillier AL, Sassone-Corsi P & Loeffler JP 1991 The protooncogene c-fos is induced by corticotropin-releasing factor and stimulates proopiomelanocortin gene transcription in pituitary cells. Neuroendocrinology 5 1301-1310.
14. Boutillier AL, Monnier D, Koch B & Loeffler JP 1994 Pituitary adenyl cyclase-activating peptide: a hypophysiotropic factor that stimulates proopiomelanocortin gene transcription, and proopiomelanocortin-derived peptide secretion in corticotropic cells. Neuroendocrinology 60 493-502.
15. Boutillier AL, Monnier D, Lorang D, Lundblad JR, Roberts JL & Loeffler JP 1995 Corticotrophin releasing hormone stimulates proopiomelanocortin transcription by cFos-dependent and -independent pathways: characterization of an API site in exon 1. Molecular Endocrinology 9 745-755.
16. Brown WH 1928 A case of pluriglandular syndrome: 'Diabetes of bearded women'. Lancet ii 1022-1023.
17. Chang ACY, Israel A, Gazdar A & Cohen SN 1989 Initiation of proopiomelanocortin mRNA from a normally quiescent promoter in a human small cell lung cancer cell line. Gene 84 115-126.
18. Chen R, Lewis KA, Perrin MH & Vale WW 1993 Expression cloning of a human corticotropin-releasing-factor receptor. Proceedings of the National Academy of Sciences of the USA 90 8967-8971.
19. Clark AJL, Lavender PM, Coates P, Johnson MR & Rees LH 1990a In vitro and in vivo analysis of the processing and fate of the peptide products of the short proopiomelanocortin mRNA. Molecular Endocrinology 4 1737-1743.
20. Clark AJL, Stewart MF, Lavender PM, Farrell W, Crosby SR, Rees LH & White A 1990b Defective glucocorticoid regulation of proopiomelanocortin gene expression and peptide secretion in a small cell lung cancer cell line. Journal of Clinical Endocrinology and Metabolism 70 485-490.
21. Creemers J, Roebroek A & Van de Ven W 1992 Expression in human lung tumor cells of the proprotein processing enzyme PC1/PC3: cloning and primary sequence of a 5Kb cDNA. FEBS Letters 300 82-88.
22. Crosby SR, Stewart MF, Ratcliffe JG & White A 1988 Direct measurement of the precursors of adrenocorticotropin in human plasma by two-site immunoradiometric assay. Journal of Clinical Endocrinology and Metabolism 67 1272-1277.
23. Cushing H 1932 The basophil adenomas of the pituitary body and their clinical manifestations. Bulletin of the Johns Hopkins Hospital 50 137-195.
24. Drouin J, Trifiro MA, Plante RK, Nemer M, Eriksson P & Wrange O 1989 Glucocorticoid receptor binding to a specific DNA sequence is required for hormone-dependent repression of pro-opiomelanocortin gene transcription. Molecular Cell Biology 9 5305-5314.
25. Farrell WE, Clark AJL, Stewart MF, Crosby SR & White A 1992 Bromocriptine inhibits pro-opiomelanocortin mRNA and ACTH precursor secretion in small cell lung cancer cell lines. Journal of Clinical Investigation 90 705-710.
26. Farrell WE, Stewart MF, Clark AJL, Crosby SR, Davis JRE & White A 1993 Glucocorticoid inhibition of ACTH peptides: small cell lung cancer cell lines are more resistant than pituitary corticotroph adenoma cells. Journal of Molecular Endocrinology 10 25-32.
27. Fuller PJ, Lim ATW, Barlow JW, White EL, Khalid BA, Copolov DL, Lolait S, Funder JW & Stockrigt JR 1984 A pituitary tumor producing high molecular weight adrenocorticotropin-related peptides: clinical and cell culture studies. Journal of Clinical Endocrinology and Metabolism 58 134-142.
28. Gaitan D, Turney MK, Zhou PH, Orth DN & Kovacs WJ 1992 Glucocorticoid receptor structure and function in an ectopic ACTH-secreting human tumor cell line. Proceedings of the Endocrine Society, San Antonio. Abstract No 1240.
29. Gardiner-Garden M & Fromer M 1987 CpG islands in vertebrate genomes. Journal of Molecular Biology 196 261-282.
30. Gerrero MR, McEvilly RJ, Turner E, Lin CR, O'Connell S, Jenne KJ, Hobbs MV & Rosenfeld MG 1993 Brn-30: A POU-domain protein expressed in the sensory, immune, and endocrine systems that functions on elements distinct from known octamer motifs. Proceedings of the National Academy of Sciences of the USA 90 10841-10845.
31. Glembotski CC 1982 Acetylation of alpha MSH and β endorphin in the rat intermediate pituitary. Journal of Biological Chemistry 257 10493-10500.
32. Hale AC, Millar JB, Ratter SJ, Pickard JD, Doniach I & Rees LH 1985 A case of pituitary dependent Cushing's disease with clinical and biochemical features of the ectopic ACTH syndrome. Clinical Endocrinology 22 479-488.
33. Jameson LJ, Lindell C & Habener JF 1986 Evolution of different transcriptional start sites in the human luteinizing hormone and gonadotropin subunit genes. DNA 5 227-234.
34. Jeannotte L, Burbach JPH & Drouin J 1987a Unusual proopiomelanocortin ribonucleic acids in extrapituitary tissues; intronless transcripts in testes and long poly (A)+ tails in hypothalamus. Molecular Endocrinology 1 749-757.
35. Jeannotte L, Trifiro MA, Plante RK, Chamberland M & Drouin J 1987b Tissue-specific activity of the proopiomelanocortin gene promoter. Molecular and Cellular Biology 7 4058-4064.
36. Jingami H, Nakanishi S, Imura H & Numa S 1984 Tissue distribution of messenger RNAs coding for opioid peptide precursors and related RNA. European Journal of Biochemistry 142 441-447.
37. de Keyzer Y, Bertagna X, Lenne F, Girard F, Luton JP & Kahn A 1985 Altered proopiomelanocortin gene expression in ACTH producing non-pituitary tumors. Journal of Clinical Investigation 76 1892-1898.
38. de Keyzer Y, Bertagna X, Luton JP & Kahn A 1989a Variable modes of proopiomelanocortin gene transcription in human tumors. Molecular Endocrinology 3 215-223.
39. de Keyzer Y, Rousseau-Merck MF, Luton JP, Girard F, Kahn A & Bertagna X 1989b Pro-opiomelanocortin gene expression in human phaechromocy tomas. Journal of Molecular Endocrinology 2 175-181.
40. de Keyzer Y, Auzan C, Lenne F, Beldjord C, Thibonnier M, Bertagna X & Clauser E 1994 Cloning and characterization of the human V3 pituitary vasopressin receptor. FEBS Letters 356 215-220.
41. de Keyzer Y, Lenne F, Auzan C, Beldjord C, Luton JP, Clauser E and Bertagna X 1995 Expression of the pituitary-specific vasopressin v3 and CRH receptors in human endocrine tumors. Proceedings of the Endocrine Society, Washington DC. Abstract No 391.
42. Kozak M 1986 Point formations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes. Cell 44 283-292.
43. Kraus J, Buchfelder M & Hollt V 1993 Regulatory elements of the human proopiomelanocortin gene promoter. DNA Cell Biology 12 527-536.
44. Kuhn JM, Proeschel MF, Seurin D, Bertagna X, Luton JP & Girard F 1989 Comparative assessment of ACTH and lipotropin plasma levels in the diagnosis and follow-up of patients with Cushing's syndrome: a study of 210 cases. American Journal of Medicine 86 678-684.
45. Lacaze-Masmonteil T, de Keyzer Y, Luton JP, Kahn A & Bertagna X 1987 Characterization of proopiomelanocortin transcripts in human non-pituitary tissues. Proceedings of the National Academy of Sciences of the USA 84 7261-7265.
46. Liddle GW, Island D & Meador CK 1962 Normal and abnormal regulation of corticotropin secretion in man. Recent Progress in Hormone Research 18 125-166.
47. Lowry P, Linton EA & Hodgkinson SC 1989 Analysis of peptide hormones of the hypothalamic pituitary adrenal axis using 'two site' immunoradiometric assays. Hormone Research 32 25-29.
48. Mains RE & Eipper BA 1983 Phosphorylation of rat and human adrenocorticotropin related peptides: physiological regulation and studies of secretion. Endocrinology 112 1986-1995.
49. Mains RE, Eipper BA & Ling N 1977 Common precursor to corticotropins and endorphins. Proceedings of the National Academy of Sciences of the USA 74 3014-3018.
50. Meador CK, Liddle GW, Island DP, Nicholson WE, Lucas CP, Nuckton JG & Luetscher JA 1962 Cause of Cushing's syndrome in patients with tumors arising from 'nonendocrine' tissue. Journal of Clinical Endocrinology and Metabolism 22 693-703.
51. Nakai Y, Usui T, Tsukada T, Takahashi H, Fukata J, Fukushima M, Senoo K & Imura H 1991 Molecular mechanisms of glucocorticoid inhibition of human proopiomelanocortin gene transcription. Journal of Steroid Biochemistry and Molecular Biology 40 301-306.
52. Nakanishi S, Inoue A, Kita N, Nakamura M, Chang ACY, Cohen SN & Numa S 1979 Nucleotide sequence of cloned cDNA for bovine corticotropin-β lipotropin precursor. Nature 278 423-427.
53. Nussbaum SR, Gaz RD & Arnold A 1990 Hypercalcemia and ectopic secretion of parathyroid hormone by an ovarian carcinoma with rearrangement of the gene for parathyroid hormone. New England Journal of Medicine 323 1324-1328.
54. Orth DN, Nicholson WE, Mitchell WM, Island DP & Liddle GW 1973 Biologic and immunologic characterization and physical separation of ACTH and ACTH fragments in the ectopic ACTH syndrome. Journal of Clinical Investigation 52 1756-1769.
55. Phifer RF, Orth DN & Spicer SS 1974 Specific demonstration of the human hypophyseal adrenocorticomelanotropic (ACTH/MSH) cell. Journal of Clinical Endocrinology and Metabolism 39 684-692.
56. Picon A, Leblond-Francillard M, Raffin-Sanson ML, Lenne F, Bertagna X & de Keyzer Y 1995 Functional analysis of the human pro-opiomelanocortin promoter in the small cell lung carcinoma cell line DMS-79. Journal of Molecular Endocrinology 15 187-194.
57. Ratcliffe JG, Scott AP, Bennett HPJ, Lowry PJ, McMartin C, Strong JA & Walbaum PR 1973 Production of a corticotrophin-like intermediate lobe peptide and of corticotrophin by a bronchial carcinoid tumour. Clinical Endocrinology 2 51-55.
58. Ratter SJ, Lowry PJ, Besser GM & Rees LH 1980 Chromatographic characterization of adrenocorticotrophin in human plasma. Journal of Endocrinology 85 359-369.
59. Ratter SJ, Gillies G, Hope H, Hale AC, Grossman A, Gaillard R, Edwards CRW & Rees LH 1983 Proopiocortin related peptides in human pituitary and ectopic ACTH secreting tumors. Clinical Endocrinology 18 211-218.
60. Ray DW, Littlewood AC, Clark JL, Davis JRE & White A 1994 Human small cell lung cancer cell lines expressing the proopiomelanocortin gene have aberrant glucocorticoid receptor function. Journal of Clinical Investigation 93 1625-1630.
61. Reincke M, Allolio B, Saeger W, Kaulen D & Winkelmann W 1987 A pituitary adenoma secreting high molecular weight adrenocorticotropin without evidence of Cushing's disease. Journal of Clinical Endocrinology and Metabolism 65 1296-1300.
62. Riegel AT, Remenick J, Wolford RG, Berard DS & Hager GL 1990 A novel transcriptional activator (PO-B) binds between the TAT box and cap site of the proopiomelanocortin gene. Nucleic Acids Research 18 4513-4521.
63. Scopsi L, Gullo M, Rilke F, Martin S & Steiner DF 1995 Proprotein convertases (PC1/PC3 and PC2) in normal and neoplastic human tissues: their use as markers of neuroendocrine differentiation. Journal of Clinical Endocrinology and Metabolism 80 294-301.
64. Seidah NG, Rochemont J, Hamelin J, Benjannet S & Chrétien M 1981a The missing fragment of the prosequence of human pro-opiomelanocortin: sequence and evidence for C-terminal amidation. Biochemical and Biophysical Research Communications 102710-716.
65. Seidah NG, Rochemont J, Hamelins J, Lis M & Chretien M 1981b Primary structure of the major human pituitary proopiomelanocortin NH2-terminal glycopeptide. Journal of Biological Chemistry 257 7977-7984.
66. Seidah NG, Gaspar L, Mion P, Marcinkiewicz M, Mbikay M & Chrétien M 1990 cDNA sequence of two distinct pituitary proteins homologous to Kex2 and Furin gene products: tissue-specific mRNAs encoding candidates for pro-hormone processing proteinases. DNA Cell Biology 9 415-424.
67. Seidah NG, Marcinkiewicz M, Benjannet S, Gaspar L, Beaubieu G, Mattei MG, Lazure C, Mbikay M & Chretien M 1991 Cloning and primary sequence of a mouse candidate prohormone convertase PC1 homologous to PC2, Furin, and Kex2: distinct chromosomal localization and messenger RNA distribution in brain and pituitary compared with PC2. Molecular Endocrinology 5 111-122.
68. Smeekens SP & Steiner DF 1990 Identification of a human insulinoma cDNA encoding a novel mammalian protein structurally related to the yeast dibasic processing protease Kex 2. Journal of Biological Chemistry 265 2997-3000.
69. Steenbergh PH, Höppener JWM, Zandberg J, Roos BA, Jansz HS & Lips CJM 1984 Expression of the proopiomelanocortin gene in human medullary thyroid carcinoma. Journal of Clinical Endocrinology and Metabolism 58 904-908.
70. Stewart PM, Gibson S, Crosby SR, Penn R, Holder R, Ferry D, Talcher N, Phillips P, London DR & White A 1994 ACTH precursors characterize the ectopic ACTH syndrome. Clinical Endocrinology 40 199-204.
71. Suda T, Tozawa F, Dobashi I, Horiba N, Ohmori N & Yamakado M 1993 Corticotropin-releasing hormone, proopiomelanocortin, and glucocorticoid receptor gene expression in adrenocorticotropin-producing tumors in vitro. Journal of Clinical Investigation 92 2790-2795.
72. Takahashi H, Hakamoto Y, Walanabe Y, Kikuno R, Miyata T & Numa S 1983 Complete nucleolide sequence of the human corticotropin-β-lipotropin precursor gene. Nucleic Acids Research 11 6847-6858.
73. Texier PL, de Keyzer Y, Lacave R, Vieau D, Lenne F, Rojas-Miranda A, Verley JM, Luton JP, Kahn A & Bertagna X 1991 Proopiomelanocortin gene expression in normal and tumoral human lung. Journal of Clinical Endocrinology and Metabolism 73 414-420.
74. Themen M & Drouin J 1991 Pituitary proopiomelanocortin gene expression requires synergistic interactions of several regulatory elements. Molecular Cell Biology 11 3492-3503.
75. Themen M & Drouin J 1993 Cell-specific helix-loop-helix factor required for pituitary expression of the proopiomelanocortin gene. Molecular and Cellular Biology 130 2342-2353.
76. Tremblay Y, Tretjakoff I, Pterson A, Antakly T, Xian Zhang C & Drouin J 1988 Pituitary-specific expression and glucocorticoid regulation of a proopiomelanocortin fusion gene in transgenic mice. Proceedings of the National Academy of Sciences of the USA 85 8890-8894.
77. Tremblay J, Lammonerie T, Lanctot C, Therrien M & Drouin J 1995 A novel homeobox transcription factor is expressed in early pituitary development and is a major determinant for cell-specific transcription of the proopiomelanocortin gene. Proceedings of the Endocrine Society, Washington DC. Abstract No 18-2.
78. Tsukada T, Nakai Y, Jingami H, Imura H, Tau S & Nakanishi S 1981 Identification of the mRNA coding for the ACTH-beta-lipotropin precursor in a human ectopic ACTH producing tumor. Biochemical and Biophysical Research Communications 98 535-542.
79. Tsukada T, Nakai Y, Fukushima M, Usui T, Imura H & Takebe H 1994 Functional analysis of the cell-specific enhancer in the human proopiomelanocortin gene by β-galactosidase histochemical staining. DNA Cell Biology 13 755-762.
80. Usui T, Nakai Y, Tsukada T, Fukata J, Nakaishi S, Naitoh Y & Imura H 1989 Cyclic AMPC-responsive region of the human pro-opiomelanocortin (POMC) gene. Molecular and Cellular Endocrinology 62 141-146.
81. Vieau D, Massias JF, Girard F, Luton JP & Bertagna X 1989 Corticotrophin-like intermediary lobe peptide as a marker of alternate proopiomelanocortin processing in ACTH-producing non-pituitary tumours. Clinical Endocrinology 31 691-700.
82. Vieau D, Linard CG, Mbikay M, Lenne F, Chretien M, Luton JP & Bertagna X 1992 Expression of the neuroendocrine cell marker 7B2 in human ACTH secreting tumours. Clinical Endocrinology 36 597-603.
83. Vieau D, Seidah NG, Chrétien M & Bertagna X 1994 Expression of the prohormone convertase PC2 correlates with the presence of CLIP in human ACTH secreting tumors. Journal of Clinical Endocrinology and Metabolism 79 1503-1509.
84. White A & Clark A 1993 The cellular and molecular basis of the ectopic ACTH syndrome. Clinical Endocrinology 39 131-142.
85. Whitfeld P, Seeburg P & Shine J 1982 The human proopiomelanocortin gene: organization, sequence and interspersion with repetitive DNA. DNA 1 133-143.
86. Yalow RS & Berson SA 1971 Size heterogeneity of immunoreactive human ACTH in plasma and in extracts of pituitary glands and ACTH-producing thymoma. Biochemical and Biophysical Research Communications 44 439-445.