Chromatographic resolution of several racemic 9-fluorenyl derivatives on a bonded cellulose derived chiral stationary phase for HPLC

Tetrahedron Asymmetry

Volumn 7, Issue 3, 1996, Pages 633-636

  Velasco, Dolores ^a   Yu, Zhanru ^a   Franco, Pilar ^a   Minguillón, Cristina ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

FLUORENE DERIVATIVE;

AFFINITY CHROMATOGRAPHY; ARTICLE; DRUG PURIFICATION; ENANTIOMER; GAS CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INTERMETHOD COMPARISON; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; TECHNIQUE;

EID: 0029995213     PISSN: 09574166     EISSN: None     Source Type: Journal    
DOI: 10.1016/0957-4166(96)00051-1     Document Type: Article

References (14)

1. E. Brown, A. Lézé and J. Touet, Tetrahedron: Asymmetry 1992, 3, 841.
2. E. H. Huntress, K. Pfister and K. H. T. Pfister, J. Am. Chem. Soc. 1942, 64, 2845.
3. At atmospheric pressure, in methylene chloride/ethanol (10:2), using 10% palladium over charcoal as a catalyst.
4. D. E. Ward and C. K. Rhee, Tetrahedron Lett. 1991, 32, 7165.
5. 2, 244.5 min. Gas chromatographic system: Hewlett Packard 5890; column: SE-54 (25m x 0.20mm ID); mobile phase: He (20 psi); temperature: 200°C (isotherm).
6. 1H-NMR spectra obtained in a Varian GEMINI-200 espectrometer (200 MHz).
7. 2 their baseline peak widths.
8. L. Oliveros, C. Minguillón and T. González, J. Chromatogr. A 1994, 672, 59.
9. The chromatographic resolutions were performed on a 10 × 0.46 cm ID column. Mobile phase: heptane/chloroform (95:5). Flow rate: 1 ml/min, UV detection 1 254 nm.
10. (a) L. Oliveros, C. Minguillón and P. López, French Patent n. 2714671;
11. (b) L. Oliveros, P. López, C. Minguillón and P. Franco, J. Liq. Chromatogr. 1995, 18, 1521;
12. (c) C. Minguillón, P. Franco, L. Oliveros and P. López, J. Chromatogr. A 1995, in press.
13. The chromatographic resolutions were performed on a 15 × 0.46 cm ID column containing a mixed 10-undecenoate/3,5-dimethylphenylcarbamate of cellulose bonded to allylsilica gel. Flow rate: 1 ml/min.
14. The chromatographic resolutions were performed on a 25 × 0.46 cm ID column, containing a mixed 10-undecenoate/3,5-dimethylphenylcarbamate of cellulose bonded to allylsilica gel. Mobile phase: heptane/2-propanol (90:10). Flow rate: 1 ml/min, UV detection 1 230 nm. HPLC system consisting of a Waters 600E pump, a Waters 717 auto sampler (Millipore, Milford, MA, USA) equipped with a waters 996 photo-diode array detector and a Perkin-Elmer 241LC polarimetric detector (Perkin-Elmer, Uberlingen, Germany).