Effect of dexloxiglumide and spiroglumide, two new CCK-receptor antagonists, on gastric emptying and secretion in the rat: Evaluation of their receptor selectivity in vivo

Alimentary Pharmacology and Therapeutics

Volumn 10, Issue 3, 1996, Pages 411-419

  Scarpignato, C ^a,b,e   Kisfalvi, I ^c   D'Amato, M ^d   Varga, G ^d  

^a UNIVERSITY OF PARMA   (Italy)

^b UNIVERSITÉ DE NANTES   (France)

^c INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

^d Rotta Research Laboratorium   (Italy)

^e Maggiore Hospital   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLECYSTOKININ A RECEPTOR; CHOLECYSTOKININ B RECEPTOR; CHOLECYSTOKININ OCTAPEPTIDE; CHOLECYSTOKININ RECEPTOR BLOCKING AGENT; DEXLOXIGLUMIDE; LOXIGLUMIDE; PENTAGASTRIN; SPIROGLUMIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG RECEPTOR BINDING; IN VIVO STUDY; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; STOMACH ACID SECRETION; STOMACH EMPTYING;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; GASTRIC ACID; GASTRIC EMPTYING; HORMONE ANTAGONISTS; KETO ACIDS; MALE; PENTAGASTRIN; PENTANOIC ACIDS; PROGLUMIDE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, CHOLECYSTOKININ; SINCALIDE; SPIRO COMPOUNDS;

EID: 0029994857     PISSN: 02692813     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.0953-0673.1996.00411.x     Document Type: Article

References (54)

1. Woodruff GN, Hughes J. Cholecystokinin antagonists. Ann Rev Pharmacol Toxicol 1991; 31: 469-501.
2. Miller LJ. Characterization of cholecystokinin receptors on human gastric smooth muscle tumors. Am J Physiol 1984; 247: G402-10.
3. D'Amato M, Stamford IF, Bennett A. Studies of three non-peptide cholecystokinin antagonists (devazepide, lorglumide and loxiglumide) in human isolated alimentary muscle and guinea-pig ileum. Br J Pharmacol 1991; 102: 591-5.
4. Schjoldager B, Molero X, Miller LJ. Functional and biochemical characterization of the human gallbladder muscularis mucosa. Gastroenterology 1989; 96: 1119-25.
5. Morini G, Barocelli E, Impicciatore M, et al. Receptor type for cholecystokinin on isolated intestinal smooth muscle cells of the guinea pig. Regul Pept 1990; 28: 313-21.
6. Mutt V. Cholecystokinin: isolation, structure, and functions. In: Jerzy Glass GB, ed. Gastrointestinal Hormones. New York: Raven Press, 1980: 169-221.
7. Bertaccini G. Peptides: Gastrointestinal hormones. In: Bertaccini G, ed. Handbook of Experimental Pharmacology. Vol. 59. Berlin: Springer, 1982: 11-83.
8. Dockray GJ. Physiology of enteric neuropeptides. In: Johnson LR, ed. Physiology of the Gastrointestinal Tract, 2nd edn. New York: Raven Press, 1987: 41-66.
9. Corazziari E, Solomon T, Grossman MI. Effect of ninety-five percent pure cholecystokinin on gastrin-stimulated acid secretion in man and dogs. Gastroenterology 1979: 77: 91-5.
10. Mayer E, Elashoff J, Mutt V, Walsh J. Reassessment of gastric acid inhibition of cholecystokinin and gastric inhibitory peptide in dogs. Gastroenterology 1982; 83: 1047.
11. Lloyd KCK, Raybould HE, Walsh JH. Cholecystokinin inhibits gastric acid secretion through type "A" cholecystokinin receptors and somatostatin in rats. Am J Physiol 1992; 263: G287-92.
12. Roche S, Bali J-P, Galleyrand J-C, Magous R. Characterization of a gastrin-type receptor on rabbit parietal cells using L365,260 and L364,718. Am J Physiol 1991; 260: G182-8.
13. Sandvik AK, Waldum HL. CCK-B (gastrin) receptor regulates gastric histamine release and acid secretion. Am J Physiol 1991; 260: G925-8.
14. Dourish CT, Hill DR. Classification and function of CCK receptors. Trends Pharmacol Sci 1987; 8: 207-8.
15. Lotti VJ, Chang RSL. A new potent and selective non-peptide gastrin antagonist and brain cholecystokinin receptor (CCK-B) ligand: L-365.260. Eur J Pharmacol 1989; 162: 273-80.
16. Lee YM, Beinborn M, McBride EW, et al. The human brain cholecystokinin B/gastrin receptor. Cloning and characterization. J Biol Chem 1993; 268: 8164-9.
17. Fink AS, Gilbert S, Green H, Taylor IL. Potential methodologic problems with in vivo immunoneutralization of pancreatic polypeptide. Pancreas 1987; 2: 320-5.
18. Lloyd KCK, Maxwell V, Kovacs TOG, et al. Cholecystokinin receptor antagonist MK-329 blocks intestinal fat-induced inhibition of meal-stimulated gastric acid secretion. Gastroenterology 1992; 102: 131-8.
19. A antagonist loxiglumide. Br J Pharmacol 1996; submitted.
20. Scarpignato C, Varga G, Dobronyi I, Papp M. Effect of a new potent CCK antagonist, lorglumide, on caerulein-, and bombesin-induced pancreatic secretion and growth in the rat. Br J Pharmacol 1989; 96: 661-9.
21. Scarpignato C, Varga G, Corradi C. Effect of CCK and its antagonists on gastric emptying. J Physiol (Paris) 1993; 87: 291-500.
22. Varga G, Papp M, Scarpignato C. Effect of devazepide on caerulein and camostate induced delay of gastric emptying in the rat. Pharmacol Res 1992; 25 (Suppl. 2): 288-9.
23. Scarpignato C. Cholecystokinin antagonists and motilides: pharmacology and potential in the treatment of gastroesophageal reflux disease and other digestive motor disorders. Front Gastrointest Res 1992; 20: 90-128.
24. Hahne WF, Jensen RT, Lemp GF, et al. Proglumide and benzotript: members of a different class of cholecystokinin receptor antagonists. Proc Natl Acad Sci USA 1981; 78: 6304-8.
25. Rovati LC, Makovec F. New pentanoic acid derivatives with potent CCK antagonistic properties: different activity on the periphery vs. central nervous system. In : Wang RY, Schoenfeld R, eds. Cholecystokinin Antagonists. New York: Alan R. Liss, 1988: 1-11.
26. Makovec F, Peris W, Revel L, et al. Structure-antigastrin activity relationships of new (R)-4-benzamido-5-oxopentanoic acid derivates. J Med Chem 1992; 35: 28-38.
27. Revel L, Ferrari F, Makovec F, et al. Characterization of antigastrin activity in vivo of CR 2194, a new R-4-benzamido-5-oxo-pentanoic acid derivate. Eur J Pharmacol 1992; 216: 217-24.
28. Varga G, Kisfalvi K, Scarpignato C. CR-2194 and CR-2017: new tools to differentiate between CCK-A and CCK-B/Gastrin receptors in vivo. Gut 1993; 34 (Suppl. 3): S21.
29. Scarpignato C, Capovilla T, Bertaccini G. Action of caerulein on gastric emptying of the conscious rat. Arch Int Pharmacodyn Ther 1980; 246: 286-94.
30. Meddings JB, Scott RB, Fick GH. Analysis and comparison of sigmoidal curves: Application to dose-response data. Am J Physiol 1989; 257: G982-9.
31. Bitar KN, Makhlouf GM. Receptor on smooth muscle cells: characterization by contraction and specific antagonists. Am J Physiol 1982; 5: G400-7.
32. Grider JR, Makhlouf GM. Regional and cellular heterogeneity of cholecystokinin receptors mediating muscle contraction in the gut. Gastroenterology 1987; 92: 175-80.
33. Menozzi D, Gardner JD, Jensen RT, Maton PN. Properties of receptors for gastrin and CCK on gastric smooth muscle cells. Am J Physiol 1989; 257: G73-9.
34. Grider JR, Makhlouf GM. Distinct receptors for cholecystokinin and gastrin on muscle cells of stomach and gallbladder. Am J Physiol 1990; 259: G184-90.
35. Buéno L, Fioramonti J. Drug effects on gastric emptying in animal models depend on the nature of test meals used. Am J Physiol 1988; 254: G637.
36. Gue M, Fioramonti J, Buéno L. Influence of stress on gastric emptying depends on the nature of meals, stressors, and animal species. J Gastrointest Motil 1990; 2: 18-22.
37. Liberge M, Riviere PMJ, Buéno L. Influence of enkaphalinase inhibitors on gastric emptying in mice depends on the nature of the meal. Life Sci 1988; 42: 2047-53.
38. Fioramonti J, Fargeas MJ. Bueno L. Involvement of endogenous opiates in regulation of gastric emptying of fat test meals in mice. Am J Physiol 1988; 255: G158-61.
39. Bruley des Varannes S, Mizrahi M, Curran P, et al. Role of cholecystokinin in the regulation of gastric emptying and motility. Gastroenterology 1990; 98: A331.
40. Decktor DL, Pendleton RG, Elnitsky AT, et al. Effect of metoclopramide, bethanechol and the cholecystokinin receptor antagonist, L-364,718, on gastric emptying in the rat. Eur J Pharmacol 1988; 147: 313-6.
41. Defaux JP, Pascaud X, Soulard P, Junien JL. Effect of JO 1754. a new CCK(A) antagonist on gastric emptying. Eur J Pharmacol 1990; 183: 2187.
42. Dubois A, Bruley des Varannes S, Mizrahi M, et al. Role of cholecystokinin in the regulation of gastric function after caloric meals. Gastroenterology 1991; 100: A439.
43. Green T, Dimaline R, Peikin S, Dockray GJ. Action of the cholecystokinin antagonist L-364,718 on gastric emptying in the rat. Am J Physiol 1988; 255: G685-9.
44. Gould RJ, Fioravanti C, Cook PG, Solomon HF. A model of gastric emptying in cats shows solid emptying is promoted by MK-329: a CCK antagonist. J Nucl Med 1990; 31: 1494-1500.
45. Shillaber G, Davison JS. Proglumide, a cholecystokinin antagonist, increases gastric emptying in rats. Am J Physiol 1987; 252: R353-60.
46. Varga G, Campbell DR, Bussjaeger LJ, Solomon TE. Role of gastrin and cholecystokinin receptors in regulation of peptone-stimulated gastric acid secretion in conscious rats. Eur J Pharmacol 1993; 250: 37-42.
47. Murphy MG, Sytnik B, Kovacs TOG, et al. The gastrin-receptor antagonist L-365,260 inhibits stimulated acid secretion in humans. Clin Pharmacol Ther 1993; 54: 533-9.
48. Hirst BH, Elliott KJ, Ryder H, Szelke M. Inhibition of gastric- and histamine-stimulated gastric acid secretion by gastrin and cholecystokinin antagonists in the rat. Aliment Pharmacol Ther 1991; 5: 31-9.
49. Eissele R, Koop H, Bothe-Sandfort, R Arnold. Effect of gastrin receptor antagonists on gastric acid secretion and gastrin and somatostatin release in the rat stomach. Digestion 1992; 53: 179-88.
50. Chang RSL, Lotti VJ, Chen TB, Kunkel KA. Characterization of the binding of [3H]-(±)-L-364718: a new potent nonpeptide cholecystokinin antagonist radioligand selective for peripheral receptors. Mol Pharmacol 1986; 30: 212-7.
51. Varga G, Reidelberger RD, Campbell DR, et al. Effects of CCK-A and CCK-B/gastrin receptor antagonists on gastric acid and pepsin secretion in conscious rats. Gastroenterology 1991; 100: A672.
52. Van de Burg FJ, Jansen JBMJ, Kuijpers RJ, Lamers VBHW. Inhibition of meal-stimulated gastric acid secretion by gastrin immunoneutralization in rats. Eur J Pharmacol 1991; 198: 197-201.
53. Lloyd KCK, Raybould HE, Tache Y, Walsh JH. Gastrin mediates meal-stimulated acid secretion in urethane-anesthetized rats. Gastroenterology 1990; 98: A81.
54. Graffner H, Ekelund M, Hakanson R. Anaesthetic agents suppress basal and stimulated gastric acid secretion. Are intramural neurons involved? Scand J Gastroenterol 1991; 26: 1200-4.