Mice that carry the resistance allele of the Bcg gene (Bcgr) develop a superior capacity to stabilize bacille Calmette-Guérin (BCG) infection in their lungs and spleen over a protracted period in the absence of specific immunity

Clinical and Experimental Immunology

Volumn 104, Issue 1, 1996, Pages 44-47

  Medina, E ^a   North, R J ^a  

^a TRUDEAU INSTITUTE   (United States)

Author keywords

Bcg gene; BCG infection; Natural resistance; T cell depleted mice

Indexed keywords

BCG VACCINE; HYDROCORTISONE ACETATE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; GENETIC REGULATION; HOST RESISTANCE; LUNG INFECTION; MACROPHAGE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPLEEN; SUBCUTANEOUS DRUG ADMINISTRATION; T LYMPHOCYTE;

ANIMALS; GENES, DOMINANT; HYDROCORTISONE; IMMUNITY; LUNG; LYMPHOCYTE DEPLETION; MACROPHAGES; MICE; MICE, INBRED A; MICE, MUTANT STRAINS; MYCOBACTERIUM BOVIS; SPLEEN; T-LYMPHOCYTES; TIME FACTORS; TUBERCULOSIS;

EID: 0029994673     PISSN: 00099104     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2249.1996.d01-656.x     Document Type: Article

References (12)

1. Gros P, Skamene E, Forget A. Genetic control of natural resistance to Mycobacterium bovis (BCG) in mice. J Immunol 1981; 127:2417-21.
2. Pelletier M, Forget A, Bourassa D, Gros P, Skamene E. Immunohistopathology study of Mycobacterium bovis (BCG) infection in innately resistant and susceptible mice. J Immunol 1982; 129:2179-82.
3. Skamene E, Gros P, Forget A, Kongshavn PAL, St Charles C, Taylor BA. Genetic regulation of resistance to intracellular pathogens. Nature 1982; 297:506-9.
4. Skamene E. Genetic control of susceptibility to mycobacterial infections. Rev Infec Dis 1989; 11:394-9.
5. Plant J, Glynn AA. Locating Salmonella resistance gene on mouse chromosome 1. Clin Exp Immunol 1979; 37:1-6.
6. Bradley DJ, Taylor BA, Blackwell J, Evans EP, Freeman J. Regulation of Leishmania populations within the host. III Mapping of the locus controlling susceptibility to visceral leishmaniasis in the mouse. Clin Exp Immunol 1979; 37:7-14.
7. Gros P, Skamene E, Forget A. Cellular mechanism of genetically controlled host resistance to Mycobacterium bovis (BCG). J Immunol 1983; 131:1966-72.
8. Buschman E, Apt AS, Nickonenko BV, Moroz AM, Averbakh MH, Skamene E. Genetic aspects of innate resistance and acquired immunity to mycobacteria in inbred mice. Spring Semin Immunol 1988; 10:319-36.
9. Vidal SM, Malo D, Vogan K, Skamene E, Gros P. Natural resistance to infection with intracellular parasites: isolation of a candidate for Bcg. Cell 1993; 73:469-85.
10. + T cells. J Exp Med 1992; 176:581-4.
11. North RJ, Izzo AA. Mycobacterial virulence. Virulent strains of Mycobacterium tuberculosis have faster in vivo doubling times and are better equipped to resist growth-inhibiting functions of macrophages in the presence and absence of specific immunity. J Exp Med 1993; 177:1723-33.
12. Pierce CH, Dubos RJ, Schaefer WB. Multiplication and survival of tubercle bacilli in the organs of mice. J Exp Med 1953; 97:189-95.